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Showing papers in "Tetrahedron in 2015"



Journal ArticleDOI
TL;DR: In this paper, the fulltext file will be made open to the public on 15 April 2017 in accordance with publisher's 'Terms and Conditions for SelfArchiving', and the full-text file is made available under the CC-BY-NC-ND 4.0 license.

222 citations


Journal ArticleDOI
TL;DR: This report briefly discusses the reusable directing group assisted functionalization of unactivated remote alkyl C–H bonds and their synthetic potential in organic chemistry and their potential utility for the rapid synthesis of complex molecular entities.

165 citations


Journal ArticleDOI
TL;DR: The structural relationship of the juvenile hormone and methyl farnesoate suggests a possible biosynthetic pathway may be involving the homologation of two of the olefinic methyl groups to ethyl groups, which would be very attractive, short, and potentially very practical.

145 citations



Journal ArticleDOI
TL;DR: This review summarizes recent developments in the C-H-functionalization of the distal positions of pyridines, quinolines and related azaheterocycles with the focus on the scope, site-selectivity and mechanistic aspects of the reactions.

128 citations



Journal ArticleDOI
TL;DR: An overview of reductive trifluoromethylation reactions using electrophilic reagents is given in this article, where the reagents are described using the prefixes "þCF3".

96 citations



Journal ArticleDOI
TL;DR: The non-toxic magnetic CuFe2O4 nanoparticles have been synthesized, characterized, and used as an efficient catalyst for synthesis of new derivatives for 1,2,4,5-tetrasubstituted imidazoles in excellent yields.

90 citations


Journal ArticleDOI
TL;DR: The utility of Cp∗Co(III)-catalysts was expanded to oxidative C-C bond-forming reaction in this article, where in situ generated Cp ∗Co (III) catalysts, rather than a preformed cationic Cp ∼ Co(III) complex, was effective.

Journal ArticleDOI
TL;DR: In this article, the authors revisited the network of anthocyanins and the one of related compounds, such as vitisins, described in detail, showing that less colorant is necessary to confer colour to the wine and also explaining the colour change from the red-violet in young wines to the redorange observed in aged wines.


Journal ArticleDOI
TL;DR: In this article, acid additive effects in the Ir-catalyzed C-H amidation of arylphosphoryl compounds were examined. And the role of carboxylic acid additive operating both in the generation of an iridacyclic intermediate and in the protodemetalation process to release amidated products.

Journal ArticleDOI
TL;DR: In this article, the authors gratefully acknowledge CONACyT of Mexico (grant 181816), Ministerio de Economia y Competitividad (Grant CTQ2013-40855-R), and Gobierno de Aragon -FSE (research group E40).

Journal ArticleDOI
TL;DR: In this article, regiodivergent C-H direct chlorination on 8-acylaminoquinolines could be realized by using N-chlorosuccinimide (NCS) as a source.

Journal ArticleDOI
TL;DR: In this article, Ganoderma lucidum has been used in China for the prevention of a wide range of diseases including diabetic nephropathy, and the results showed that individual enantiomers of these substances significantly inhibit monocyte chemotactic protein 1 (MCP-1) and fibronectin production in a dose-dependent manner.

Journal ArticleDOI
TL;DR: A near-infrared (NIR) and colorimetric fluorescent probe system was developed for Carbon Monoxide via a Pd0-mediated Tsuji-Trost reaction and has great potential for fluorescence imaging of intracellular CO in living cells.

Journal ArticleDOI
TL;DR: In this paper, a general two-step approach for direct synthesis of (1H-tetrazol-5-yl)furoxan ammonium salts with various functional substituents based on initial effective synthesis of cyanofuroxans by dehydration of furoxancarboxylic acid amides by the action of (CF3CO)2O/Py followed by [3+2]-cycloaddition of the cyanofurusans to ammonium azide, generated in situ from TMSN3 and NH4F, has been

Journal ArticleDOI
TL;DR: In this paper, a simple, convenient, and environmentally benign protocol for the synthesis of benzimidazoles from ortho-phenylenediamines and aldehydes via aerobic oxidation was developed in wet organic solvents.

Journal ArticleDOI
TL;DR: An assessment of emerging C-H activation catalysts of the type [(COD)Ir(IMes)(PR3)]PF6 in the deuteration of N-heterocycles is divulged in this article.


Journal ArticleDOI
TL;DR: A FeCl3-catalyzed multicomponent reaction was developed for the facile synthesis of coumarin-3-carboxylic ester derivatives in a highly atom-economic and environmentally friendly way as mentioned in this paper.

Journal ArticleDOI
TL;DR: In this article, a metal-free photochemical strategy for the direct aromatic perfluoroalkylation of phenols is reported, which occurs at ambient temperature and under illumination by a fluorescent light bulb.

Journal ArticleDOI
TL;DR: This versatile method for the synthesis of mono- and bis-arylthioindoles via I 2 catalysed direct oxidative sulfenylation of indoles with thiophenols shows a broad functional group tolerance furnishing good to excellent yields.


Journal ArticleDOI
TL;DR: In this article, eight monoterpenoid indole and quinoline alkaloids, scholarisines H-O (1-8), together with six known analogues, were isolated from seven-year stored leaves of Alstonia scholaris.

Journal ArticleDOI
TL;DR: An overview of the syntheses of these cyclic guanidine-containing natural products is provided.

Journal ArticleDOI
TL;DR: Iodocyclization has been found to be general for a broad range of N-propargylic β-enaminones and tolerated the presence of aliphatic, aromatic and heteroaromatic groups with electron-withdrawing and electron-donating substituents.

Journal ArticleDOI
TL;DR: In this article, a metal-free iodine-promoted decarboxyltive couplings between cinnamic acids and sodium benzene sulfinates was developed for the synthesis of vinyl sulfones via C-S bond formation reaction.