Showing papers in "Tetrahedron in 2019"

TL;DR: This work summarizes a variety of C-N cross-coupling reactions using biaryl monophosphines as supporting ligands, with the goal of directing synthetic chemists towards the ligands and conditions best suited for a particular coupling.

TL;DR: A comprehensive review on azirine chemistry was published in Tetrahedron as discussed by the authors, focusing on the new developments in the synthesis and reactivity of azirines for the period from 2012 until the end of 2018.

TL;DR: Challenges facing both academic and industrial applications such as enzyme stability, multistep reactions and reactions in continuous flow are focussed on.

TL;DR: In this article, the authors highlight the applications of various cyclopropanol ring opening/expansion/fragmentation reactions in the total syntheses of natural products, and highlight the application of these reactions in different structural scaffolds which are frequently found in many natural products.

TL;DR: It is demonstrated that the E+-factor can constitute a multiple of the classical E-factor and therefore must not be neglected striving for a holistic estimation of the environmental impact.

TL;DR: In this article, the introduction and early development of phase-transfer catalyzed (PTC) reactions to afford racemic or enantioenriched natural and unnatural amino acids is discussed.

TL;DR: A review of the methods for indoline synthesis can be found in this article, where the authors reviewed the methods used to synthesize indoline from both natural and synthetic origins from 2010 to 2018.

TL;DR: In this article, the tandem reaction strategy of the Passerini/Wittig reaction based on the in situ capture of isocyanides was reported, which avoids the separation, purification, and storage of isosocyanide.

TL;DR: The tetrahydro-β-carboline (THBC) nucleus is a predominant feature of a vast array of naturally occurring alkaloids and has been found to exhibit significant biological activities, which promote to develop a plethora of synthetic methods for the construction of THBCs as mentioned in this paper.

TL;DR: In this article, a review of transition-metal-catalyzed direct C-H bond amination reactions is presented, focusing on their applications in organic synthesis and/or modification.

TL;DR: This review focuses exclusively on Lewis base catalysis mediated by chiral phosphine oxides with emphasis on mechanistic aspects, covering most of the publications related to this field since their first use as organocatalyst in 2005 until the end of March 2019.

TL;DR: In this paper, the authors give an overview of synthetic methods for transition metal-catalyzed α-alkylation of amines by C(sp3)H bond activation.

TL;DR: In this article, a direct synthesis of 3-(bromomethylene)isobenzofuran-1(3H)-ones from 2-alkynylbenzoic acids is developed through a regioselective 5-exo-dig bromocyclization.

TL;DR: A review of homocoupling reactions for the synthesis of symmetrical biaryl compounds can be found in this article, where the Ullmann coupling is used to promote a new aryl-aryl bond.

TL;DR: This radical-mediated C-F coupling is capable of fluorinating secondary and tertiary alcohols efficiently, complementing previously reported nucleophilic deoxyfluorination protocols.

TL;DR: An aggregation-induced emission (AIE)-active fluorescent chemosensor based on a tetraphenylethene (TPE) unit has been successfully designed and synthesized as discussed by the authors.

TL;DR: In this article, the catalysts in click chemistry reactions, mechanism insights and use of other metals beyond copper associated with Azide-Alkyne Cycloadditions (AAC) are presented and critically discussed.

TL;DR: In this article, a turn-on fluorescent probe Cou-1-N2H4, which contains an acetyl group as the trigger unit and the fluorescence quencher, is developed.

TL;DR: In this article, a short report summarizes the recent advances in the area of fluorine-containing organic compound synthesis and summarizes some of the most important developments in this area. But carbenes are in general highly reactive species, though which various transformations are possible.

TL;DR: A series of unsymmetrical 1,3-disubstituted benzimidazolium chlorides were synthesized as N-heterocyclic carbene precursors as discussed by the authors.

TL;DR: In this paper, a colorimetric and fluorometric dual-channel sensor DA with a favorable optical property and high specificity via a facile synthesis for Cu 2+ was developed, which showed a remarkably rapid response and high selectivity for CU 2+ over other metal ions with low detection limit of 15.1

TL;DR: A Mn(III)-promoted radical oxidative ipso-annulation reaction of biaryl ynones with sodium sulfinates to construct various substituted spiro[5.5]trienones has been explored in this article.

TL;DR: The review summarizes recent developments in the area of photoinduced reactions of organoboron compounds with an emphasis on borylation of haloarenes, amine derivatives, and redox-active esters of carboxylic acids.

TL;DR: In this paper, a method for the selective synthesis of 2-substituted benzimidazoles is described through condensation reaction of o-phenylenediamines with a wide rang of aliphatic, aromatic and heteroaromatic aldehyde substrates using Bronsted acidic ionic liquid as a reusable catalyst under metal-free conditions at ambient temperature.

TL;DR: This work benchmarked human drug metabolite (HDM) synthesis by several evolved UPO mutants, focusing on dextromethorphan, naproxen and tolbutamide, and highlights the heme access channel as the main feature on which to focus when designing evolved UPOs.

TL;DR: In this article, the activation energy of the 32CA reaction of the simplest nitrile imine with dicyanoethylene is 5.6 ǫ −1 lower than that involving ethylene, in agreement with the high polar character of the former reaction.

TL;DR: This focused review highlights applications of flavin-dependent enzymes in organic synthesis by selecting examples of monoamine oxidases, ene-reductases, monooxygenases and halogenases in target-oriented synthesis.

TL;DR: An efficient visible-light photocatalytic protocol for the vicinal heteroaryl- and oximino-substituted alkyl sulfones is described, which features a good functional group tolerance and a broad substrate scope.

TL;DR: In this article, an efficient NNN pincer Ru(II)-catalyzed preparation of quinazolines via acceptorless dehydrogenative strategy has been developed.

TL;DR: In this article, an efficient protocol for cobalt (II)-catalyzed regioselective aryl C8 H bond alkoxylation of 1-naphthylamine derivatives with readily available alcohols has been developed.