Showing papers in "Tetrahedron Letters in 2015"

TL;DR: A review of the previous researches employing visible light photoredox catalysts for difunctionalization of alkenes can be found in this paper, which summarizes the previous works.

TL;DR: In this article, the focus of the paper is on examples where molecular design has been used to improve the performance of the molecules, and as such it may serve as an inspiration for future design.

TL;DR: In this article, the authors summarized the recent development in the copper-catalyzed propargylic substitutions with various nitrogen, carbon, oxygen, and sulfur nucleophiles.

TL;DR: In this article, the recent advances in metal-catalyzed mechanochemical reactions, one of the most rapidly developing areas of modern organic mechanosynthesis, are highlighted and discussed.

TL;DR: The click-chemistry approaches based on Huisgen's cycloaddition reaction are particularly attractive and have received enormous attention over the last decade and a half, due to their utility in preparing compounds with diverse applications, from drugs to linkers for bioconjugation.

TL;DR: In this paper, the major advances in catalytic synthesis of indoles through transition-metal-catalyzed C-H activation were summarized and discussed for possible applications of these synthetic protocols.

TL;DR: A broad variety of applications ranging from supramolecular to biological chemistry is presented to highlight the great potential of HTIs as upcoming, alternative photoswitches.

TL;DR: In this article, a Co(III)-catalyzed intermolecular C(sp 2 )-C(sp 3 ) assembly of α-diazomalonates using a direct C-H functionalization logic was developed.

TL;DR: The metabolic transformation of amino acids into five, six, and seven-member heterocycles reveals the chemical logic and enzymatic machinery for shunting primary metabolites into bioactive heterocyclic nitrogen scaffolds.

TL;DR: In this paper, it was shown that in the presence of 1-butyl-3-methylimidazolium cations, a 1,3-dipolar cycloaddition between gem-chloronitroethene and (Z)-C-4-methoxyphenyl-N-phenylnitrone is expected to take place much faster than under conventional conditions, the one-step mechanism being replaced by a two-stage mechanism involving a zwitterionic intermediate.

TL;DR: In this paper, the authors highlight recent progress in the activation of allylic and benzylic C-F bonds for the synthesis of functionalized molecules, including 3-fluoropropenes and quinone methide intermediates.

TL;DR: In this article, the synthesis of pyranopyrazole derivatives is investigated via a one-pot four component reaction of aldehydes and isatins, hydrazine hydrate, malononitrile, and β-keto ester in H 2 O-EtOH (9:1) under neutral conditions.

TL;DR: In this paper, the authors delineated recent developments in the context of sulfur and selenium-catalyzed oxidative and isohypsic functionalization reactions of simple alkenes.

TL;DR: In this article, a synergistic effect of the hydrogen bond on the cycloaddition of CO2 and epoxides to form cyclic carbonates was investigated through experimental study and characterization.

TL;DR: The introduction of aryl motifs at the C3 position of indole nuclei via dearomatization reactions has been the subject of intensive efforts in the last years and has culminated in several total syntheses of natural products as mentioned in this paper.

TL;DR: In this paper, selected recent examples of total synthesis of natural and pharmaceutical products enabled by organocatalytic reactions, highlighting the importance of OCL reactions in fostering structures of biological importance.

TL;DR: In this article, a summary of recent advances in transition-metal-catalyzed etherification of unactivated CH bonds is presented, with different directing groups and catalyst systems via C(sp2)H and C (sp3)H bonds activation.

TL;DR: This digest letter summarizes the most effective routes to terminal ynamides and the current state of selective nucleophilic addition, substitution and coupling reactions, including the first examples of asymmetric synthesis.

TL;DR: In this paper, various methods of preparing enantiomerically enriched planar-chiral transition-metal complexes using substoichiometric chiral sources are surveyed, and most of the asymmetric reactions in these categories are transitionmetal-catalyzed reactions, and there are a few examples of organocatalytic reactions.

TL;DR: In view of the spectacular role of transition metals in synthetic chemistry, novel o-carborane functionalization methods for both cage carbon and boron vertices have been developed by using transition metal-promoted reactions as mentioned in this paper.

TL;DR: In this paper, the C-Si bond activation via a direct transition metal insertion has recently gained growing attention in the organic chemical community, and the process not only shows a new and unique entry to functionalize the C−Si bond, but also presents a powerful method to synthesize diverse organosilanes via formation of a new C −Si bond.

TL;DR: This review summarizes some recent progresses of bioorthogonal reactions for site-specific protein labeling and engineering, and highlights the powers of using these methods to study the biological functions of some proteins.

TL;DR: In this article, a mild and efficient methodology was developed for the ipso-hydroxylation of arylboronic acids using montmorillonite K-10 supported silver nanoparticles (AgNPs) as catalyst and aqueous H2O2 as oxidant.

TL;DR: In this article, a ratiometric fluorescent sensor for Fe3+ based on the conjugation of rhodamine and coumarin has been designed and synthesized, the free sensor displays fluorescence emission at 475nm, on the addition of Fe 3+ to an aqueous solution of HL, the sensor shows significant fluorescence enhancement at 550nm which should be attributed to an intramolecular fluorescence resonance energy transfer (FRET) mechanism from coumaralin to Rhodamine 6G.

TL;DR: A mild, efficient, and metal-free oxidative cleavage of C-C double bond to aldehydes utilizing eosin Y as an organophotoredox catalyst has been developed in this article.

TL;DR: In this article, a simple, efficient and eco-friendly method for quinoxaline synthesis from inexpensive and readily available diamines and phenacyl bromides by catalyst-and additive-free protocol was developed.

TL;DR: In this article, a visible-light-mediated photocatalytic ethoxycarbonyldifluoromethylation/1,2-carbon migration of alkenols is described.

TL;DR: Carbonyl compounds represent an important class of synthetic intermediates in organic chemistry with growing industrial significance as mentioned in this paper, and metal-catalyzed carbonylation is one of the most prominent methods for their synthesis.

TL;DR: A computational study using DFT methods was performed for an array of mono and disubstituted benzynes and indolynes to enable the further use of unsymmetrical arynes in organic synthesis.

TL;DR: The Chitosan anchored Cu(II) Schiff base complexes (C1-C3) have been synthesized and characterized by FTIR, UV, FE-SEM, EDAX, TGA, AAS and elemental analysis as discussed by the authors.