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Showing papers in "The American Journal of Gastroenterology in 2000"


Journal ArticleDOI
TL;DR: An improvement in irritable bowel syndrome symptoms with diarrhea and abdominal pain being statistically significant after Bonferroni correction is revealed.

734 citations


Journal ArticleDOI
TL;DR: A systematic baseline endoscopic biopsy protocol using histology and flow cytometry identifies subsets of patients with Barrett's esophagus at low and high risk for progression to cancer as mentioned in this paper.

592 citations


Journal ArticleDOI
TL;DR: Colorectal cancer prevention 2000: screening recommendations of the American College of Gastroenterology.

569 citations



Journal ArticleDOI
TL;DR: Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome.

558 citations


Journal ArticleDOI
TL;DR: Short-term stress does not trigger exacerbation in ulcerative colitis, but long-term perceived stress increases the risk of exacerbation over a period of months to years.

430 citations


Journal ArticleDOI
TL;DR: The goal in this review is to provide the reader with an understanding of the basic physiology of serotonin, a mediator of the brain–gut connection, serotonin receptor subtypes, the role of serotonin in diseases of the gut, and the potential role of agonists and antagonists in GI clinical therapeutics.

427 citations


Journal ArticleDOI
TL;DR: The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children shows marked variation in the severity of the disease in children aged four to six months.

368 citations


Journal ArticleDOI
TL;DR: In this paper, a retrospective review of medical records of all patients with colon perforations from endoscopy over a 10-year period was performed. But the authors did not find any statistically significant relationship between gender and perforation with a training fellow.

362 citations


Journal ArticleDOI
TL;DR: The IBS-QOL is responsive to treatment in a referral-based clinical population of patients with functional bowel disorders, and there was a significant correlation between change scores on the IBS -QOL and the other measures of treatment effect.

361 citations


Journal ArticleDOI
TL;DR: A consensus diagnosis of LGD among GI pathologists suggests an increased risk of progression from LGD to HGD or carcinoma, and a high degree of interobserver variability is seen in the histological diagnosis of Barrett's esophagus–related LGD.

Journal ArticleDOI
TL;DR: The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangsitis is investigated.

Journal ArticleDOI
TL;DR: The results support the use of EUS as a primary diagnostic modality in the evaluation and management of patients with neuroendocrine tumors of the pancreas and show that EUS was more accurate than angiography with or without stimulation testing, transcutaneous ultrasound, and CT in those patients undergoing further imaging procedures.

Journal ArticleDOI
TL;DR: This guideline is a revision of a guideline originally developed and published in 1993 and is intended to indicate preferable approaches to the management of patients with colorectal polyps based on available scientific evidence.

Journal ArticleDOI
TL;DR: In conjunction with ACG Consumer Brochure: “ACG Recommendations on Colorectal Cancer Screening for Average and Higher Risk patients in Clinical Practice”.

Journal ArticleDOI
TL;DR: The dysmotility in this subset of IBS patients was characterized by significantly increased occurrences of powerful HAPCs that paralleled rapid colon transit and were accompanied by abdominal pain, suggesting that this powerful contraction is one of the causes of abdominal pain.

Journal ArticleDOI
TL;DR: Lactobacillus GG, a variant of L. casei sps rhamnosus, has been studied extensively in adults and children as mentioned in this paper, and has proven beneficial effects on intestinal immunity.

Journal ArticleDOI
TL;DR: In this article, a specific cyclooxygenase-2 inhibitor, rofecoxib, was used to prevent intestinal polyposis in the APC Δ 716 mouse.

Journal ArticleDOI
TL;DR: A four-quadrant, 1-cm endoscopic biopsy protocol performed at closely timed intervals consistently detects early cancers arising in HGD in Barrett’s esophagus and should be used in patients with HGD who do not undergo surgical resection.

Journal ArticleDOI
TL;DR: Alcohol facilitates the development of oropharyngeal, esophageal, gastric, and colon cancer, and initial research suggests that wine may be comparatively less carcinogenic.

Journal ArticleDOI
TL;DR: The findings from this observational study raise the possibility that prophylactic use of low-dose aspirin may convey an increased risk of gastrointestinal bleeding, which may offset some of its benefits.

Journal ArticleDOI
TL;DR: The incidence of UGI ulcer complications associated with celecoxib was 8-fold lower than with nonspecific, nonsteroidal anti-inflammatory drugs (NSAIDs), and that in non-NSAID users reported in the literature was similar to that in patients receiving placebo in the RCTs.

Journal ArticleDOI
TL;DR: This is the first demonstration in the United Kingdom that the mortality of patients with dementia who are fed by gastrostomy is considerable, and selected patients may wish to advise against Gastrostomy feeding in selected patients within this clinical setting.

Journal ArticleDOI
TL;DR: The polyp guideline: diagnosis, treatment, and surveillance for patients with colorectal polyps shows clear trends in survival and morbidity among patients with these conditions.

Journal ArticleDOI
TL;DR: A new variant of inflammatory bowel disease is present in this group of children with developmental disorders, and scores of frequency and severity of inflammation were significantly greater in both affected children and those with UC, compared with controls.

Journal ArticleDOI
TL;DR: The serum leptin levels were significantly higher in patients with NASH, while they were not affected by chronic hepatitis, and this elevation is out of proportion to BMI of these patients and may be related to hyperlipidemia in most.

Journal ArticleDOI
TL;DR: The historical aspects of PJS polyposis are highlighted with special emphasis on its extraintestinal manifestations, particularly genital tract tumors.

Journal ArticleDOI
TL;DR: NSAIDs provoke disease activity in both ulcerative colitis and Crohn's disease and should be avoided in patients with a history of IBD whenever possible.

Journal ArticleDOI
TL;DR: A meta-analysis and overview of the literature on treatment options for left-sided ulcersative colitis and ulcerative proctitis is presented.

Journal ArticleDOI
TL;DR: Isolation of Mycobacterium avium subsp paratuberculosis from breast milk of Crohn's disease patients shows good results in terms of protecting against infection and promoting good immune response in patients.