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Showing papers in "The American Journal of Gastroenterology in 2014"


Journal ArticleDOI
TL;DR: This ACG Clinical Guideline is presented an evidence-based approach to diagnosis and management of DILI with special emphasis on DILi due to herbal and dietary supplements and DilI occurring in individuals with underlying liver disease.

630 citations




Journal ArticleDOI
TL;DR: The criteria developed through the Rome process, currently in its third iteration, have been those most widely employed in clinical trials and, therefore, most relevant to any review of the literature on the management of these disorders.

521 citations



Journal ArticleDOI
TL;DR: Decreasing HCC incidence and liver cancer mortality rates among Asians/Pacific Islanders, men aged 35–49 years, and the nonsignificant increase in overall H CC incidence rates suggest that the peak of the epidemic may be near or have passed.

375 citations



Journal ArticleDOI
TL;DR: This ACG practice guideline provides an evidence-based approach to the diagnosis and management of FLL and considers not only malignant liver lesions, but also benign solid and cystic liver lesions in the differential diagnosis.

303 citations


Journal ArticleDOI
TL;DR: Fructose but not inulin distends the small bowel with water more than fructose, but causes few symptoms in healthy volunteers, and adding glucose to fructose reduces the effect of fructose on SBWC and breath hydrogen.

286 citations


Journal ArticleDOI
TL;DR: PNPLA3 is associated with an increased risk of advanced fibrosis among patients with a variety of liver diseases and is an independent risk factor for HCC among patientswith nonalcoholic steatohepatitis or alcohol-related cirrhosis.

266 citations



Journal ArticleDOI
TL;DR: Recommendations for anal fissure and hemorrhoids lean heavily on adaptation from the American Society of Colon and Rectal Surgeons Practice Parameters from the most recent published guidelines in 2010 and 2011 and supplemented with subsequent publications through 2013.

Journal ArticleDOI
TL;DR: Soluble fiber is effective in treating IBS, and Bran did not appear to be of benefit, although the study did not uncover any evidence of harm from this intervention, as others have speculated from uncontrolled data.

Journal ArticleDOI
TL;DR: A fourfold increase in the incidence of CD in the United Kingdom over 22 years is found, with large regional variations in prevalence, which could reflect differences in diagnosis between CD and DH and the possibility that diagnosing and treating CD prevents the development of DH.

Journal ArticleDOI
TL;DR: Based on meta-analysis, approximately 1 in 27 CRCs are interval CRCs, although the confidence in these estimates is low because of the heterogeneity among the studies.

Journal ArticleDOI
TL;DR: The results confirm the need for early repeat colonoscopy with low-quality bowel preparation, but suggest that patients with intermediate/fair preparation quality may be followed up at standard guideline-recommended surveillance intervals without significantly affecting quality as measured by ADR.



Journal ArticleDOI
TL;DR: Using the NIH PROMIS framework, eight GI symptom scales that can now be used for clinical care and research across the full range of GI disorders are developed.

Journal ArticleDOI
TL;DR: 16.1% of this community cohort of adult Hong Kong Chinese volunteers had a fatty pancreas by the definition of the normal range of pancreatic fat, and central obesity, hypertriglyceridemia, and hyperferritinemia are associated with fatty Pancreas.

Journal ArticleDOI
TL;DR: DW-MREC is a reliable tool to assess inflammation in colonic (ADC) and ileal (Clermont score) CD and its use in daily practice would avoid gadolinium injection.

Journal ArticleDOI
TL;DR: Polyp and adenoma detection rates were highest among endoscopists with 9’min median normal withdrawal time, and detection of CSSPs reached its highest levels at 8–9 min.

Journal ArticleDOI
TL;DR: G-CSF is safe and effective in the mobilization of hematopoietic stem cells and improves liver function as well as survival in patients with severe alcoholic hepatitis.

Journal ArticleDOI
TL;DR: FC has a high sensitivity and a modest specificity during the diagnosis of suspected pediatric IBD and its role during the re-evaluation of those with confirmed disease is still unclear.

Journal ArticleDOI
TL;DR: There is a positive synergistic effect of alcohol and tobacco use for ESCC, and the observed combined effect of the two factors is almost double if there were no synergy.

Journal ArticleDOI
TL;DR: The presence of low ADA trough levels without AAA is strongly predictive of clinical response in 67% of cases after ADA optimization, and switching to IFX should be considered.

Journal ArticleDOI
TL;DR: SSRI medications are associated with a modest increase in the risk of upper GI bleeding, which is lower than has previously been estimated, and physicians prescribing these medications together should exercise caution and discuss this risk with patients.

Journal ArticleDOI
TL;DR: Ncroptosis is strongly associated with intestinal inflammation in children with IBD and contributes to strengthen the inflammatory process, and it is believed that RIP3 and MLKL could represent attractive targets for the management of human IBD.

Journal ArticleDOI
TL;DR: The significant burden of dietary therapy for CD argues for the need for safe adjuvant treatment, as well as interventions designed to lower the perceived burden of the GFD.

Journal ArticleDOI
TL;DR: A systematic review and meta-analysis to establish the risk of second abdominal surgery in patients with Crohn’s disease among patients who had a previous surgery and the role of time found that the 10-year risk ofsecond surgery is significantly decreasing over time.