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Showing papers in "The American Journal of Medicine in 1971"


Journal ArticleDOI
TL;DR: Two patients with Diazinon ® poisoning and the second with parathion poisoning illustrate the acute manifestations, the criteria for diagnosis, and treatment with pralidoxime and atropine in organophosphate poisoning.

564 citations


Journal ArticleDOI
TL;DR: G grossly visible CID are always associated with cardiac dysfunction and usually chronic cardiac failure, and are usually more extensive in ventricular than in atrial myocardium.

451 citations


Journal ArticleDOI
TL;DR: From an analysis of the clinical features of vitiligo and of the chemicals that cause depigmentation, a melanocyte self-destruct hypothesis for the etiology of vitILigo and graying of hair can be derived.

276 citations


Journal ArticleDOI
TL;DR: An eleven year old child with a bleeding tendency since infancy with thrombocytopenia and morphologic abnormalities of platelets and megakaryocytes, consisting of lack or paucity of granules and a peculiar gray color is described.

264 citations


Journal ArticleDOI
TL;DR: Clinical and functional features shown by fifty-eight patients during seventy-six admissions to the hospital with severe asthma are reported, including bronchodilators, antimicrobial chemotherapy and large doses of corticosteroids, and there was only one hospital death.

259 citations


Journal ArticleDOI
TL;DR: The effects of chronic ethanol consumption on ethanol and drug metabolism, four alcoholic and four nonalcoholic volunteer subjects were given ethanol for one month under metabolic ward conditions, resulted in accelerating the rate of disappearance of ethanol from the blood of the alcoholics and nonalcoholics.

247 citations


Journal ArticleDOI
TL;DR: It is demonstrated that the electrocardiographic manifestations of all three degrees of A-V block can result from conduction abnormalities present in either of these three regions, viz, A- V node, BH and the His-Purkinje system.

223 citations


Journal ArticleDOI
TL;DR: Detailed hematologic studies were carried out on sixty-five consecutive patients admitted to the hospital because of alcoholism, demonstrating the rapidity of the appearance and disappearance of both megaloblastic and ring sideroblastic defects and the importance of variations in diet, vitamin and alcohol intake.

213 citations


Journal ArticleDOI
TL;DR: A new syndrome consisting of chronic liver disease typical of primary biliary cirrhosis together with scleroderma, Raynaud's phenomenon, calcinosis cutis and telangiectasia was described in this article.

201 citations


Journal ArticleDOI
TL;DR: Primary hyperparathyroidism may be much more common than previously suspected, occurring frequently in an asymptomatic form without complications and detected by screening technics.

199 citations


Journal ArticleDOI
TL;DR: A review of pathologic data obtained from the literature indicates that involvement of autonomic pathways in this condition is not uncommon and an approach to management that takes into account the autonomic status may lessen the mortality of this condition.

Journal ArticleDOI
TL;DR: Mortality over a twenty-six year period was ascertained in a group of 21,447 diabetic patients in the Joslin Clinic in Boston as discussed by the authors, by a comparison of the observed number of deaths with the number expected if the sex-and age-specific rates of the general Massachusetts population over the same period of time applied Observed deaths from all causes were significantly in excess of the expected number in both sexes and in nearly all age groups throughout the period of study However, the excess mortality risk was greatest in patients between the ages of thirty and thirty-nine years.

Journal ArticleDOI
TL;DR: The decline in rheumatic fever, the increased age of the patients with endocarditis, sophisticated medical and surgical procedures and the prolonged survival of patients with r heumatic heart disease have all been major factors in changing the nature of infective end Carditis.

Journal ArticleDOI
TL;DR: The results suggest that thymectomy produces stable remission by eliminating these thymic centers; but its effect is delayed because of the long life span of the existing pool of small immunocompetent lymphocytes.

Journal ArticleDOI
TL;DR: Two cases of chronic vitamin A intoxication in adults are described in this article, and the literature literature is reviewed, and the authors suggest that large doses of vitamin A should be given only for limited periods under close medical supervision and should not be given during pregnancy.

Journal ArticleDOI
TL;DR: The sudden, late appearance of multiple complications and the autopsy demonstration of a newly recognized side effect, ovarian destruction, are described in a young girl treated for a prolonged period with cyclophosphamide.

Journal ArticleDOI
TL;DR: Observations indicate that nocardiosis is a significant and often fatal opportunistic infection in patients being treated for cancer, but further studies are needed to define the clinical and epidemiologic spectrum of this disease in man.

Journal ArticleDOI
TL;DR: In this paper, the response to acute water ingestion (20 ml/kg body weight) was determined in sixteen patients with myxedema and eighteen control subjects, and the results indicated an abnormality in water excretion in the patients.

Journal ArticleDOI
TL;DR: It is concluded that the Sezary cells belong to the lymphoid series and that they are potentially neoplastic ("prelymphomatous") but still able to respond to some of the controls regulating lymphocyte numbers in normal subjects.

Journal ArticleDOI
TL;DR: The results of several investigations have suggested that thyroid hormone itself has direct inotropic and chronotropic effects on the heart, which may provide the explanation for the failure of antiadrenergic agents such as propranolol to abolish completely the augmentation of heart rate and contractility observed in patients with hyperthyroidism.

Journal ArticleDOI
TL;DR: In India noncirrhotic portal fibrosis (portal hypertension without demonstrable intrahepatic or extrahepatics obstruction) accounted for seventy-five (25 per cent) of 300 cases of portal hypertension studied by us, with marked splenomegaly of long duration and recurrent hemorrhage from esophageal varices.

Journal ArticleDOI
TL;DR: The view is favored that the pathology of the leaflet precedes that of the papillary muscles in the majority of patients, and the mechanism of production of the myocardial pathology in patients with the billowing posterior mitral leaflet remains unknown.

Journal ArticleDOI
TL;DR: Differences in the nutritional state of the different populations may explain the frequency of azotemic rickets and osteomalacia in Europe and Asia, as compared with their reputed infrequency in the United States.

Journal ArticleDOI
TL;DR: In this article, an extensive survey revealed a significant biostatistical difference in the incidence of metabolic bone disease when 342 patients who had been treated with various types of partial gastrectomy were compared with a series of 180 patients with peptic ulcer of similar age and sex distribution.

Journal ArticleDOI
TL;DR: An epidemic of heroin overdose is described which occurred over a seventeen-month period and involved 149 patients who were predominately young, black or Puerto Rican males andHypoxia appeared to be the cause of the pulmonary edema and cardiac arrhythmias.

Journal ArticleDOI
TL;DR: The lowered blood ammonia levels under treatment are compatible with the idea that ammonia absorption from the colon is decreased under lactulose treatment, and substantiates the impression that this therapy is particularly useful for long-term control of PSE.

Journal ArticleDOI
TL;DR: Clinical, electrocardiographic and biochemical data are correlated with pathologic findings in six patients receiving chronic dialysis who demonstrated moderate to severe metastatic calcification of the myocardium at postmortem, and one patient who died suddenly showed nearly complete calcific obliteration of the sino-atrial node.

Journal ArticleDOI
TL;DR: Twenty-one examples of lymphomatous infiltration of the leptomeninges have been encountered in six years in one Center, where this complication occurred in patients with advanced disease, denoted a grave prognosis and contributed to the cause of death.

Journal ArticleDOI
TL;DR: In four patients in whom an acute nephrotic syndrome was associated with clinical relapse of Hodgkin's disease, it is suggested that a substance originating in tumor damages the renal glomerular basement membrane, perhaps after combining in an antigen-antibody complex.

Journal ArticleDOI
TL;DR: Serum immunoreactive PTH of patients with surgically proved parathyroid adenomas decreases with induced hypercalcemia and increases in response to hypocalcemia caused by EDTA infusions, challenging the concept of parathyoid adenoma autonomy.