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Showing papers in "The American Journal of Medicine in 2010"


Journal ArticleDOI
TL;DR: In this paper, a systematic review compared current treatment practices for stroke prevention in atrial fibrillation with published guidelines, showing that patients at high risk for stroke are often under-treated.

875 citations


Journal ArticleDOI
TL;DR: The prevalence of frequent tinnitus is highest among older adults, non-Hispanic whites, former smokers, and adults with hypertension, hearing impairment, loud noise exposure, or generalized anxiety disorder.

767 citations


Journal ArticleDOI
TL;DR: In this paper, the authors conducted a systematic search of the MEDLINE and EMBASE databases until February 2009 to assess the association between smoking and low back pain with meta-analysis.

459 citations


Journal ArticleDOI
TL;DR: This is one of the largest studies to date to quantify the risk of diagnosis of coexisting autoimmune diseases in more than 3000 index cases with well-characterized Graves' disease or Hashimoto's thyroiditis.

369 citations


Journal ArticleDOI
TL;DR: Migraine is associated with increased ischemic stroke risk, and the importance of identifying high-risk migraineurs with other modifiable stroke risk factors is underscored, which underscores the need for future studies of the effect of migraine treatment and modifiable risk factor reduction on stroke risk in migraineurs.

333 citations


Journal ArticleDOI
TL;DR: In this article, the authors identify patients with early type 2 diabetes who are at risk for rapid progression of beta-cell decline and premature development of microvascular complications, including nephropathy, retinopathy, and neuropathy.

305 citations


Journal ArticleDOI
TL;DR: In patients with respiratory disease, inhaled corticosteroid use is associated with modest increases in the risks of diabetes onset and diabetes progression, and the risks are more pronounced at the higher doses currently prescribed in the treatment of chronic obstructive pulmonary disease.

275 citations


Journal ArticleDOI
TL;DR: This review conflates dissenting views into a rational approach of managing patients with portal vein thrombosis for the general internist.

251 citations


Journal ArticleDOI
TL;DR: These prospective data from 2 generations of the Framingham Heart Study provide evidence that individuals with higher serum uric acid; including younger adults, are at a higher future risk of type 2 diabetes independent of other known risk factors.

239 citations


Journal ArticleDOI
TL;DR: Bone loss with fractures occurs in patients treated with drugs targeting the immune system, such as calcineurin inhibitors, antiretroviral drugs, selective inhibitors of serotonin reuptake, anticonvulsants, loop diuretics, heparin, oral anticoagulants, and proton pump inhibitors.

226 citations


Journal ArticleDOI
TL;DR: There was a substantial excess of suicides among all patients who had bariatric surgery in Pennsylvania during a 10-year period, and a need to develop more comprehensive longer-term surveillance and follow-up methods in order to evaluate factors associated with postbariatric surgery suicide.

Journal ArticleDOI
TL;DR: Increasing age, hypotension, absence of fever, hospital acquisition, extreme white blood cell count values, and the presence of the acquired immunodeficiency syndrome, malignancy, or renal disease were significantly associated with an increased risk of in-hospital attributable death in multivariable analysis.

Journal ArticleDOI
TL;DR: Clinicians should be highly vigilant to identify individuals with nonexposed osteonecrosis, as the impact on epidemiological data and clinical trial design could be potentially significant.

Journal ArticleDOI
TL;DR: As currently implemented, hospital computing might modestly improve process measures of quality but does not reduce administrative or overall costs.

Journal ArticleDOI
TL;DR: Clinically useful the shifting to a quantitative approach that can be defined as the "4 out of 5" rule: the diagnosis of celiac disease is confirmed if at least 4 of the following 5 criteria are satisfied: typical symptoms of Celiac disease; positivity of serum celiac Disease immunoglobulin, A class autoantibodies at high titer.

Journal ArticleDOI
TL;DR: This review aims to describe the relationship between chronic microaspiration and idiopathic pulmonary fibrosis by laying out the clinical and biologic rationale for this relationship and exploring the scientific evidence available.

Journal ArticleDOI
TL;DR: A clinic staff reminder was significantly more effective in lowering the no-show rate compared with an automated appointment reminder system.

Journal ArticleDOI
TL;DR: This work would simplify the approach to thromboprophylaxis in patients with atrial fibrillation by selecting patients with 1 definitive risk factor or a patient with a CHA(2)DS(2)-VASc score of 0 is truly low risk and could be managed with no antithrombotic therapy.

Journal ArticleDOI
TL;DR: In this paper, the effect of obesity on outcomes in atrial fibrillation patients has been investigated, and the authors performed a post hoc analysis of the National Heart, Lung and Blood Institute limited access dataset of patients who had body mass index (BMI) data available in the Atrial Fibrillation Followup Investigation of Rhythm Management (AFFIRM) study.

Journal ArticleDOI
TL;DR: Routine infectious diseases consultation should be considered for patients with S. aureus bacteremia, especially those with greater severity of illness or multiple comorbidities, especially if they have a central venous catheter at the time of diagnosis.

Journal ArticleDOI
TL;DR: Routine screening for pulmonary embolism may be advantageous because approximately one third of patients with deep venous thrombosis have silent pulmonary emblism, which sometimes involved central pulmonary arteries.

Journal ArticleDOI
TL;DR: Risk of type 2 diabetes increases when term pregnancy is followed by <1 month of lactation, independent of physical activity and body mass index in later life.

Journal ArticleDOI
TL;DR: In this article, the utilization of warfarin in atrial fibrillation/flutter patients by stroke risk level was examined by using the US MarketScan database (Thomson Reuters, New York, NY).

Journal ArticleDOI
TL;DR: Safety concerns related to timely patient follow-up remain despite automated notification of non-life-threatening abnormal laboratory results in the outpatient setting, according to an integrated electronic medical record examined.

Journal ArticleDOI
TL;DR: Optimal management of hypertension in very old coronary artery disease patients may involve targeting specific systolic and diastolic blood pressures that are higher and somewhat lower, respectively, compared with other age groups.

Journal ArticleDOI
TL;DR: In this article, platelet aggregation and endothelial function were tested before, and 1 hour after, the consumption of 250 mL (1 can) of a sugar-free energy drink, while no change was observed with control (13.7±3.7% vs 0.3±0.8% aggregation).

Journal ArticleDOI
TL;DR: Doxycycline and cefuroxime axetil had comparable efficacy in the treatment of European patients with erythema migrans and the frequency of nonspecific symptoms in patients did not exceed that of a control group at > or =6 months after enrollment.

Journal ArticleDOI
TL;DR: Clinicians unwilling to dose vancomycin in accordance with clinical practice guidelines should use an alternative agent because inadequate dosing increases the likelihood of selecting heteroresistant methicillin-resistant S. aureus isolates.

Journal ArticleDOI
TL;DR: A higher vancomYcin serum trough concentration and prolonged vancomycin therapy are associated with an increased risk of nephrotoxicity, and the decision to target increased vancomal trough concentrations should be based on an assessment of the severity of the infection and must consider the neph rotoxicity risk associated with increased van comycin levels.

Journal ArticleDOI
TL;DR: Optimal management of type 2 diabetes should include early initiation of therapy using multiple drugs, with different mechanisms of action, in combination, to delay disease progression and eventual treatment failure.