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Showing papers in "The American Journal of the Medical Sciences in 2005"


Journal ArticleDOI
TL;DR: Cross-sectional and longitudinal epidemiologic studies provide prevalence data on the metabolic syndrome based on criteria proposed by the World Health Organization and the National Cholesterol Education Program Adult Treatment Panel III, and Pharmacologic treatment of the individual components provides an alternate strategy for managing the syndrome.

274 citations


Journal ArticleDOI
TL;DR: Advances in the understanding of biologically active molecules collectively referred to as “adipokines” are reviewed and how dysregulated production of these factors in obese states mediates the pathogenesis of obesity associated metabolic syndrome.

274 citations


Journal ArticleDOI
TL;DR: The diagnosis of NASH requires a high index of suspicion, especially in obese patients over the age of 45 years who have diabetes, because these are the patients at greatest risk for developing cirrhosis.

224 citations


Journal ArticleDOI
TL;DR: The data support the notion that NAFLD is part of the spectrum of the metabolic syndrome, and no relationship was demonstrated between unexplained elevations in ALT level and microalbuminuria.

160 citations


Journal ArticleDOI
TL;DR: Osteomalacia and osteoporosis are commonly observed in patients who have had partial gastric resections for treatment of peptic ulcer disease, and relatively little has been published in the general medical literature about this postoperative complication of bariatric surgery.

150 citations


Journal ArticleDOI
TL;DR: Significant hepatotoxicity from lovastatin was very infrequent in this study, and individuals with elevated baseline liver enzyme levels did not have higher frequency of Lovastatin hepatot toxicity than those with normal liver enzymes levels.

134 citations


Journal ArticleDOI
TL;DR: It is suggested that antidepressant medication with supportive psychotherapy can successfully treat depression and improve nutritional status in chronic hemodialysis patients with depression.

108 citations


Journal ArticleDOI
TL;DR: The medication compliance subscale of the Hill-Bone Compliance Scale appears reliable and may be a useful tool for detecting noncompliant patients in outpatient settings.

99 citations


Journal ArticleDOI
TL;DR: Depression was the primary factor predicting the incidence of all three sleep symptoms and other health conditions, including respiratory symptoms and cardiovascular disease, and limitation in activities of daily living were important as well.

94 citations


Journal ArticleDOI
TL;DR: Obesity may play the most important and pivotal role in creating the conditions that lead to hypertension in the metabolic syndrome.

82 citations


Journal ArticleDOI
TL;DR: Results from this study indicate a significant problem with overweight and cardiovascular risk in rural schoolchildren, and younger children were just as likely to have risk factors as adolescents, suggesting that screening and intervention ought to begin by school age.

Journal ArticleDOI
TL;DR: The cardiometabolic syndrome is associated with endothelial dysfunction, inflammation, abnormal thrombolysis, and increased oxidative stress that accentuate progression of CVD.

Journal ArticleDOI
TL;DR: The development of resistance to linezolid should be taken into account when selecting this drug as a therapeutic option for Staphylococcus aureus patients.

Journal ArticleDOI
TL;DR: Effective management of the cardiometabolic syndrome will ultimately depend on the understanding of the underlying molecular mechanisms of key components of this disorder, such as insulin resistance.

Journal ArticleDOI
TL;DR: The roles of hyperglycemia, dyslipidemia and dyslipoproteinemia, oxidative stress, and endothelial dysfunction will be considered, and the "treatment gap" will be addressed.


Journal ArticleDOI
TL;DR: A unified definition that recognizes the increased biologic activity of the upper visceral fatty tissue and the strong association of abdominal obesity as a leading part of metabolic syndrome is proposed herein.

Journal ArticleDOI
TL;DR: It is hypothesized that gentamicin, a polyvalent cationic molecule, induces the action of calcium-sensing receptor on the thick ascending loop of Henle and distal convoluted tubule to cause renal wasting of Na+, K+, Cl-, Ca2+, and Mg2+.

Journal ArticleDOI
TL;DR: The pathogenesis and significance of dyslipidemia in the metabolic syndrome, the role of nonpharmacologic therapy with therapeutic lifestyle changes, and drug therapies, including statins, fibrates, nicotinic acid, and omega-3 fatty acids or fish oils, alone or in drug combinations, to improve lipids and reduce the chance of subsequent cardiovascular disease events are reviewed.

Journal ArticleDOI
TL;DR: The diagnosis, pathophysiology, and therapy of PCOS are discussed and upon this background, those areas held in common by PCOS and the metabolic syndrome are explored.

Journal ArticleDOI
TL;DR: The association between alcohol use and CHD risk is reviewed, putative mechanisms are explored, and recommendations are made.

Journal ArticleDOI
TL;DR: The scope and value of services provided by free clinics across the United States are described, supporting the conclusion that a variety of approaches to the care of the underserved can be used.

Journal ArticleDOI
TL;DR: The rate of true bacteremia in this study was zero, which is much lower than previous studies, and could be an impetus to reevaluate infective endocarditis prophylaxis guidelines.

Journal ArticleDOI
TL;DR: Two diabetic patients, who had been treated with human insulin, suffered from fasting hypoglycemia and postprandial hyperglycemia, and high-affinity insulin antibodies had larger capacity and stronger affinity compared with commonly insulin-treated patients.

Journal ArticleDOI
TL;DR: Mandatory ID consultation resulted in substantial cost savings and excellent outcomes, and followed-up demonstrated a single rehospitalization for unrelated issues.

Journal ArticleDOI
TL;DR: The components of the metabolic syndrome are analyzed, its pathophysiology is discussed, and an approach to the quantitative analysis of the risk factors contributing to excess cardiovascular death in the region is recommended.

Journal ArticleDOI
TL;DR: To the knowledge, this is the 25th case of hydatid cyst at an intradural extramedullary location reported in the literature, and the first in an otherwise healthy patient who presented with back pain, paraparesis, and weakness.

Journal ArticleDOI
TL;DR: This is the first reported case of amiodarone-induced hepatic cirrhosis associated with chronic treatment with 200 mg orally once per day for less than 2 years.

Journal ArticleDOI
TL;DR: Although definitive randomized controlled trials are lacking, the collective evidence suggests that treatment of dyslipidemia is associated with less decline in renal function, and the use of potent statins in high doses results in a reduction in proteinuria and in the rate of decline of renal function.

Journal ArticleDOI
TL;DR: A patient with a 20-year history of extensive perineal hidradenitis suppurativa who presented with subacute muscle weakness and sensory symptoms that are consistent with a paraneoplastic neuropathy is described.