Showing papers in "The International Journal of Biochemistry & Cell Biology in 2007"

TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.

TL;DR: The most important findings on the TRAIL signalling network and the interplay in the decisions between life and death of a tumor cell are summarised.

TL;DR: The Sox family controls cell fate and differentiation in a multitude of processes, such as male differentiation, stemness, neurogenesis, and skeletogenesis, and they review their specific molecular properties and in vivo roles, stress recent advances in the field, and suggest directions for future investigations.

TL;DR: There are currently no specific therapies that target fibroblast-associated pathology but increasing knowledge of pathological mechanisms has led to development of new agents providing hope for improved treatment of these diseases.

TL;DR: Invasion predicts the ability to generate metastasis, therefore epithelial-mesenchymal transition could provide new insights on the mechanisms underlying this detrimental process and offer novel opportunities to define clinical parameters and pharmacological treatment.

TL;DR: How dynamic modulation of the biochemical and biophysical properties of the extracellular matrix elicit a dialogue with the mammary epithelium through transmembrane integrin receptors to influence tissue morphogenesis, homeostasis and malignant transformation is focused on.

TL;DR: LIMK1 was shown to be involved in cancer metastasis, while LIMK2 activation promotes cells cycle progression, and Hsp90 regulates the levels of the LIM kinase proteins by promoting their homo-dimerisation and trans-phosphorylation.

TL;DR: It is pointed out that the environmental heterogeneity and evolutionary capacity of tumor cells that likely led to development of upregulated glycolysis could also promote adaptive strategies that confer resistance to therapies designed to inhibit glucose metabolism.

TL;DR: The purpose of this review is to consider the role of syndecan core proteins in transmembrane signalling and also their roles as co-receptors with other major classes of cell surface molecules.

TL;DR: The decision if p21(cip1/waf1) up-regulation results in cell cycle arrest or apoptosis, decides about the therapeutic efficacy of an anti-cancer treatment with HDAC inhibitors.

TL;DR: The c-Kit background, structure, downstream signalling and medical significance are summarized with particular focus on its role in hematopoietic progenitor cells and mast cells.

TL;DR: Cells expressing IDO, seemingly paradoxically, are capable of suppressing local T cell responses to promote immune tolerance under various physiological and pathophysiological conditions of medical importance, including infectious diseases, foetal rejection, organ transplantation, neuropathology, inflammatory and auto-immune disorders and cancer.

TL;DR: Recent insights into MDM2 and MDM4 regulatory functions and their implications for the design of future p53-based anticancer strategies are highlighted.

TL;DR: Thalidomide analogs are effective in the treatment of multiple myeloma and myelodysplastic syndromes for which the Food and Drug Administration granted recent approval, and each of these IMiDs remains the subject of active investigation in solid tumors, hematologic malignancies, and other inflammatory conditions.

TL;DR: Despite an impressive increase in knowledge of CD36 functions, in depth understanding of the mechanistic aspects of this protein remains elusive and this review focuses on CD36 in cardiovascular disease.

TL;DR: Genetic evidence suggests that the fly CtBP (dCtBP) and the vertebrate CtBP2 might activate transcription in a context-dependent manner and the transcriptional regulatory activity of CtBP is modulated by the nuclear NADH/NAD+ ratio and hence appears to be influenced by the metabolic status of the cell.

TL;DR: The functional connection between the regulatory machinery (i.e., the spliceosome and its accessory proteins) and their global impact on qualitative transcript variation that are only now emerging from the use of genomic technologies such as microarrays are described.

TL;DR: Results imply that ER stress-induced SREBP-2 activation occurs through the conventional pathway that normally regulates SRE BP in accordance with intracellular sterol concentration.

TL;DR: The current understanding on TGFBIp/betaig-h3 protein and its functions in morphogenesis, extracellular matrix interactions, adhesion/migration, corneal dystrophy, tumorigenesis, angiogenesis, nephropathies, osteogenesis, wound healing and inflammation are reviewed.

TL;DR: The experiments suggest that the functional expression of voltage-gated sodium channels might be an integral component of the metastatic process in non-small-cell lung cancer cells probably through its involvement in the regulation of intracellular sodium homeostasis.

TL;DR: The cholera toxin B-subunit displays the capacity to fortify immune responses to certain antigens, to act as a carrier and to be competent in inducing immunological tolerance, which makes it a promising tool for immunologists.

TL;DR: The basic molecular biology of V EGF is reviewed and recent progress in targeting the VEGF molecular pathway as therapy for angiogenic diseases such as cancer and age-related macular degeneration is summarized.

TL;DR: Evidence is presented to support the hypothesis that the effect of intrACEllular reactive oxygen species on oncogenesis is dependent on the ratio of intracellular superoxide to hydrogen peroxide, in that a predominant increase in superoxide supports cell survival and promotes oncogenic whereas a tilt in favor of hydrogenperoxide prevents carcinogenesis by facilitating cell death signaling.

TL;DR: The EGFR role in carcinogenesis and tumor progression as rational bases for the development of specific therapeutic inhibitors is reviewed.

TL;DR: Observations indicate that exported GAPDH may act as a virulence factor which could contribute to EHEC and EPEC pathogenesis.

TL;DR: Various aspects of preclinical and clinical research of the HDAC inhibitor MS-275 are described, to provide insight into the development of such a compound.

TL;DR: The analysis suggests that P. falciparum has evolved an expanded and specialized Hsp40 protein machinery to enable it successfully to invade and remodel the human erythrocyte, and a model in which these proteins are involved in chaperone-mediated translocation, folding, assembly and regulation of parasite and host proteins is proposed.

TL;DR: The recognition of a causal relationship between human papillomaviruses and cancer almost 30 years ago led to a rapid expansion of knowledge in the field, resulting in the description of the main mediators of HPV-induced carcinogenesis, the viral proteins E6 and E7.

TL;DR: Findings that assign an apoptotic role to BAG3 in some neoplastic cell types are summarized and the protein is identified as a candidate target of therapy.

TL;DR: Combinations of dietary supplementation with amino-acids such as creatine, specific anti-inflammatory drugs and perhaps drugs that target ion channels might have immediate realistic clinical benefits although rigorous research is required to determine optimal combinations of such interventions.