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Showing papers in "The International Journal of Biochemistry & Cell Biology in 2015"


Journal ArticleDOI
TL;DR: This comprehensive review will focus on how networks of ECM proteins function to regulate osteoclast- and osteoblast-mediated bone remodeling and the clinical significance of these networks on normal bone and as they relate to pathologies of bone mass and geometry will be considered.

223 citations


Journal ArticleDOI
TL;DR: It is suggested that 4-PBA may help fold proteins in the ER, attenuating the activation of the UPR, and thus potentially alleviating various pathologies, while also commenting on the possible mechanisms of action.

187 citations


Journal ArticleDOI
TL;DR: In this paper, the authors review the biochemical functions associated with these structural RNA domains, as well as the functional conservation of Y RNAs in different species, and show that the conserved structural domains of YRNAs are essential for distinct cellular functions.

162 citations


Journal ArticleDOI
TL;DR: As metabolic reprogramming from oxidative phosphorylation toward increased glycolysis is a hallmark of cancer cells; there is increasing evidence that the ketogenic diet may be beneficial as an adjuvant cancer therapy by potentiating the antitumor effect of chemotherapy and radiation treatment.

132 citations


Journal ArticleDOI
TL;DR: GO analysis of the acetylome showed that acetylated proteins are involved in the regulation of diverse cellular processes including metabolism and protein synthesis, and implicates extensive regulatory role of acetylation in this pathogen.

129 citations


Journal ArticleDOI
TL;DR: Better understanding of regulation and function of SRY in the male brain could provide entirely novel and important insights into genetic factors involved in the susceptibility of men to neurological disorders, as well as development of novel sex-specific therapies.

118 citations


Journal ArticleDOI
TL;DR: Different facets of metabolic remodeling in cancer are reviewed, from its diversity in physiology and pathology, to the search of the genetic determinants, the microenvironmental regulators and pharmacological modulators.

117 citations


Journal ArticleDOI
TL;DR: The experimental data demonstrate that LAT1 is the sole transport competent subunit of the heterodimer, which has important outcome for following studies on functional characterization and identification of specific inhibitors with potential application in human therapy.

109 citations


Journal ArticleDOI
TL;DR: The role and mechanisms of both JMJD3 and UTX have been extensively studied for their involvement in development, cell plasticity, immune system, neurodegenerative disease, and cancer and this review will focus on recent progresses made on understandingJMJD3.

109 citations


Journal ArticleDOI
TL;DR: Understanding mechanisms by which synonymous mutations contribute to complex diseases such as cancer, neurodegeneration and genetic disorders, including the limitations of codon-optimized biologics, provides insight concerning interpretation of silent variants and future molecular therapies.

103 citations


Journal ArticleDOI
TL;DR: In vitro analysis of the effect of miR-451 on proinflammatory cytokine provided evidence for negative regulation of PA-induced interleukin (IL)-8 and tumor necrosis factor-alpha (TNF-α) production and showed that Cab39 is a direct target of miRNA-451 in steatotic cells, while study showed that AMPK activated through Cab39 inhibits NF-κB transactivation induced in Steatotic HepG2 cells.

Journal ArticleDOI
TL;DR: Interactions with α7β1 integrin, which may bind to the alternatively spliced domain of tenascin-C, and α9β1 integration are able to influence the differentiation of mesenchymal stem cells into the neuronal lineage.

Journal ArticleDOI
TL;DR: The impact of Wnt signalling on multi-lineage differentiation of MSCs is summarized, the intricate interplay between Wnt and redox signals is attempted, and the question whether Wnt-mediated differentiation signals involve the intermediary role of reactive oxygen species is asked.

Journal ArticleDOI
TL;DR: The processes involved in epigenetic reprograming and the mechanisms that ensure allelic methylation at imprinted loci is retained throughout the life of the organism are examined, discussing the critical differences between mouse and humans.

Journal ArticleDOI
TL;DR: The role of nuclear-encoded factors in the response to changes in mitochondrial function is reviewed and their relevance to metabolic homeostasis is discussed, outlining the diverse and complex ways in which nuclei adapt to maintain mitochondrialHomeostasis.

Journal ArticleDOI
TL;DR: The role of DNA sequence, transcription factors, pre-existing histone modifications, and RNA in guiding PRC2 towards specific genomic loci are discussed, which defines a local chromatin state which controls accurate, cell-type-specific epigenetic silencing byPRC2.

Journal ArticleDOI
TL;DR: Inhibition of cell cycle entry and progression in a variety of cancers may be achieved with therapies designed to correct p27(Kip1) localization and/or block its degradation.

Journal ArticleDOI
TL;DR: It is shown that reactive oxygen species cannot only regard as a toxic by-product of mitochondrial respiration anymore, and homeostatic levels were shown to be necessary for correct differentiation during embryonic expansion of stem cells.

Journal ArticleDOI
TL;DR: The matricellular protein WISP1 is a member of the CCN protein family and is a downstream target of β-catenin, which makes it an emerging candidate for the detection and treatment of tumors.

Journal ArticleDOI
Shanshan Gao1, Chunli Duan1, Ge Gao1, Xiaoming Wang1, Hui Yang1 
TL;DR: Evidence is found for a link between α-Syn and IRS-1 that may represent a novel mechanism for α- Syn-associated pathogenesis and mTORC1/S6K1 signaling while activation of PP2A reversed this process.

Journal ArticleDOI
TL;DR: The expanding role of miR-7 is examined in the context of health, with emphasis on organ differentiation and development, as well as in various mammalian diseases, particularly of the brain, heart, endocrine pancreas and skin, aswell as in cancer.

Journal ArticleDOI
TL;DR: Depletion of mitofusin 2 would lead to apoptosis both in normal or hypoxic conditions; however, mitofUSin 2 overexpression could attenuate hypoxia-induced apoptosis, which represents a potential novel strategy for neuroprotection against ischemic brain damage.

Journal ArticleDOI
TL;DR: How the intricacies of mitochondrial homeostasis impinge on the intracellular propagation of mutant mtDNA is discussed, as part of a Directed Issue entitled: Energy Metabolism Disorders and Therapies.

Journal ArticleDOI
TL;DR: The current role of SAH in cardiovascular disease and its effect on several related risk factors is summarized and possible the mechanisms, such as epigenetics and oxidative stress, ofSAH are explored.

Journal ArticleDOI
TL;DR: Results illustrate that gradually reduced levels of testosterone, induced by progressive stages of diabetes mellitus, favor a metabolic reprogramming toward glycogen synthesis, which highlights a pivotal role for testosterone in the regulation of spermatogenesis metabolic support by Sertoli cells, particularly in individuals suffering from metabolic diseases.

Journal ArticleDOI
TL;DR: Functional mitochondria supported by FFA β-oxidation are essential for the accelerated cancer cell proliferation and hence anti-β-Oxidation therapeutics appears as an alternative promising approach to deter malignant tumor growth.

Journal ArticleDOI
TL;DR: It is found that appropriate autophagy activity was beneficial to the survival of NP cells in serum deprivation, while excessive Autophagy led to death of the NP cells.

Journal ArticleDOI
TL;DR: Mitochondrial structural abnormalities were seen in SE kidneys at day 1 and week 13 along with a reduction in oxidative phosphorylation (OXPHOS) proteins and activity of mitochondrial antioxidant Manganese superoxide dismutase (MnSOD).

Journal ArticleDOI
TL;DR: The aim of this review is to discuss the emerging role of miRNAs on AGE/RAGE pathway and the potential use of several mi RNAs as novel therapeutic targets.