Showing papers in "The International Journal of Biochemistry & Cell Biology in 2017"

TL;DR: It is suggested that there is no sole, definite answer to the question "how do introns enhance gene expression", rather, each intron-gene combination might undergo its own unique mixture of processes that lead to the perceptible outcome.

TL;DR: The new W4M 3.0 release is presented, which contains twice as many tools as the first version, and provides two features which are, to the authors' knowledge, unique among online resources.

TL;DR: A concise summary for the novice describing what tissue clearing is, which research problems it can be applied to, how to decide on a clearing method, and where the field is headed in the future is provided.

TL;DR: Findings indicate that endothelial senescence could be mediated through ROS and NLRP3 inflammasome signaling pathways, suggesting a potential target for the prevention of endothelialsenescence-related cardiovascular diseases.

TL;DR: High-contrast images facilitate generation of individual cell metrics via more robust segmentation and tracking, enabling formation of a label-free dynamic phenotype describing cell-to-cell heterogeneity and temporal changes.

TL;DR: Recent data indicate that alcohol impairs mitochondria function assessed by membrane potential and respiratory chain activity, and myocardial apoptosis is increased based on assessment of TUNEL staining and caspase activity.

TL;DR: It is concluded that the inclusion in clinical practice of tumor suppressive protein phosphatases has obvious potential to significantly improve therapeutic outcome in various ways, and should now definitely be pushed forward.

TL;DR: A novel targeted non-viral system for shRNA-mediated gene-silencing in cancer cells and results of gene silencing and apoptosis assay indicated that the targeted shRNA delivery system could efficiently down-regulate the Bcl-xL expression and induce 14% late apoptosis in target cancer cells with strong cell selectivity.

TL;DR: The positive effects exerted on brain functions by short-chain FAs and the consideration that they can be produced by intestinal flora metabolism contributed to the better understanding of the link between "gut-health" and "brain-health".

TL;DR: Clinical and experimental evidence is reviewed that highlights the potential importance of iron in respiratory diseases and infections and increased understanding of the role that iron plays in the pathogenesis of lung disease and respiratory infections may help inform novel therapeutic strategies.

TL;DR: The data suggests that Rad52-Cas9 fusion is a good option for enhancing CRISPR/Cas9-mediated HDR, which may be of use in future studies involving precise genome editing.

TL;DR: Resveratrol functions as a suppressor of PM-induced inflammatory signaling pathways by inhibiting COX-2/PGE2 expression in human FLSs, and attenuated PM-enhanced NADPH oxidase activity and ROS generation.

TL;DR: Clear evidence is provided that Nectin-4 is a BCSC marker and is responsible for breast cancer metastasis and experimental evidence suggesting that it utilizes WNT/β-Catenin signaling via Pi3k/Akt axis for self renewal of BCSCs.

TL;DR: How AS mechanism operates and how can be coupled to NMD to fine-tune gene expression levels are focused on and the physiological significance of the interplay among AS and NMD in human disease, such as cancer and neurological disorders is demonstrated.

TL;DR: Findings show for the first time that both the amount and structure of glycosaminoglycans are altered in IPF and these changes may contribute to the tissue remodelling in IPf by altering growth factor retention and activity, creating a pro-fibrotic ECM landscape.

TL;DR: It is shown that in the absence of α-Klotho, FGF23 augments pro-fibrotic signalling cascades in injury-primed renal fibroblasts via activation of FGFR4 and upregulation of the calcium transporter, transient receptor potential cation channel 6 and the resultant rise in intracellular calcium induced expression of NFAT responsive-genes and enhanced TGF-β1 autoinduction through non-canonical JNK-dependent pathways.

TL;DR: The results provide the new evidence supporting the tumor-suppressive role of LINC00657 in HCC, suggesting that LINC 00657 might play a role in H CC and can be a novel therapeutic target for treating HCC.

TL;DR: The data suggest FOXK2 as an oncogene and a promising prognostic biomarker in HCC and Targeting the newly identified miR-1271/FOXK2/AKT axis may represent a potential strategy for HCC intervention.

TL;DR: The SOX9 transcription factor controls the differentiation of many cell types among vertebrates and can lead to either the complete Campomelic Dysplasia syndrome, or isolated clinical features, depending upon whether the mutation occurs in the coding region or in enhancer regions.

TL;DR: It is indicated that DOX results in a decreased cardiomyocyte Mfn2 expression which promotes mitochondrial fission and ROS production further leads to card iomyocyte apoptosis.

TL;DR: Exercise induced FA-specific changes independently of dietary FA composition, but only ET attenuated the inflammatory response in VAT of HFD-fed rats, and the exercise-induced FA changes did not correlate with the inflammatory Response of rats submitted to HFD.

TL;DR: A review of the role of splicing kinases in cancer is presented in this paper, where the authors summarize the current knowledge on splicing-based kinase involvement in cancer.

TL;DR: Effects of PIM kinases and their substrates especially on cancer cell migration, invasion and metastatic growth are summarized, based on data from cell-based assays, animal experiments and patients.

TL;DR: In this paper, the authors investigated the possible interplay between glutamate dehydrogenase (GDH) and the cytosolic energy sensing enzyme 5′AMP kinase (AMPK), in both isolated islets and myotubes from mice and humans.

TL;DR: It is demonstrated that adipocytes may serve as an exogenous source of oleic acid that promotes gastric cancer cell invasion through the PI3K/Akt signaling pathway.

TL;DR: NEL can trigger mitochondrial dysfunction and disruption via elevation of Ca2+ and ROS leading to apoptosis in C. albicans cells not only at the early stages, but also at the late stages.

TL;DR: It is demonstrated for the first time that cinnamaldehyde is able to inhibit NSCLC cell growth by inducing apoptosis and reverse EMT through terminating Wnt/β-catenin pathway, which might supply further insight into cinnAMaldehyde-mediated anti-tumor effect against NSCLCs for better prognosis.

TL;DR: Results indicated that BAF57, BAF60a and SNF5 might act as novel pro-senescence factors in both normal and tumor human skin cells, and inhibiting expression of the three factors might delay the cellular senescence process.

TL;DR: In this paper, the authors used a Gas cromatography-mass spectrometry-based platform to characterize the metabolomic profiles (utilizing plasma from patients with MS) followed by a multivariate statistical analysis and comparison with a healthy control (HC) population.

TL;DR: It is indicated that miR-218 contributes to PE by targeting LASP1 to inhibit trophoblast invasion by targeting the 3'-untranslated region of the LASD gene.