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Showing papers in "The Journal of Pediatrics in 1977"


Journal ArticleDOI
TL;DR: The results of this study demonstrate a probably mechanism for measles vaccine failure in 12-month-old children and support the recommendation of the Public Health Service Advisory Committee on Immunization Practices to postpone measles vaccination to 15 months of age.

355 citations


Journal ArticleDOI
TL;DR: The data indicate that term infants who are breast fed may not require routine administration of supplemental iron and that infants fed breast milk during the entire first six to seven months of life attained greater iron stores than did those fed a cow milk formula.

309 citations


Journal ArticleDOI
TL;DR: The advantages of breast-feeding in reducing morbidity was previously shown in a group of rural infants, and observations are extended and refined to show the protection afforded by breast- feeding is greatest during the early months, increases with the duration of Breast-feeding, and appears to be more striking for serious illness.

299 citations


Journal ArticleDOI
TL;DR: Caffeine is an effective pharmacologic respirogenic agent in the preterm infant with apnea and all infants except one showed a significant decrease in the frequency of apneic episodes associated with caffeine therapy.

248 citations


Journal ArticleDOI
TL;DR: Glutamate showed the highest plasma amino acid concentrations in infants fed both the high- and low-protein casein-predominant formulas, and the concentrations of amino acids in the urine tended to parallel those of the plasma.

248 citations


Journal ArticleDOI
TL;DR: Human milk was subjected to heat treatments of graded severity and examined for its content of immunoglobulins, lactoferrin, lysozyme, vitamin B12-and folate-binder proteins, and lactoperoxidase, finding that the capacity of milk to bind folic acid and potect it against bacterial uptake was broadly true.

220 citations


Journal ArticleDOI
TL;DR: Differences in gestational age, type of delivery, and type of feeding are associated with significantly different colonization patterns of anaerobic and aerobic bacteria in the first week after birth.

199 citations


Journal ArticleDOI
TL;DR: Biochemical and morphologic studies on a patient with glutaric aciduria are presented, revealing cerebral edema, ischemic neuronal changes, and striatal degeneration in the brain with fatty changes in liver, kidney, and myocardium.

186 citations


Journal ArticleDOI
TL;DR: The data suggest that the rickets was induced by a phosphaturic substance extractable from the tumors, typical of the epidermal nevus syndrome, and suggested hypophosphatemic vitamin D-resistant rickets.

175 citations


Journal ArticleDOI
TL;DR: The probenecid loading technique is utilized to determine the concentrations of metabolites in the CSF of a clinically homogeneous group of children with MBD, indicating that there may be a neurochemical abnormality in MBD.

171 citations


Journal ArticleDOI
TL;DR: Serum levels of DHAS rose following administration of ACTH and were increased in patients with congenital adrenal hyperplasia, in whom rapid decrements followed treatment with dexamethasone, and in patients undergoing evaluation of the hypothalamic-pituitary-gonadal and -adrenal systems.

Journal ArticleDOI
TL;DR: The major problems encountered in the management of adolescent patients were patient noncompliance and physician failure to increase the glucocorticoid dose as the patient's body size increased.

Journal ArticleDOI
TL;DR: The results indicate that low-birth-weight infants who receive no supplemental iron may develop iron deficiency by three months of age and that a dose of iron of 2 mg/kg/day started at two weeks of age prevents iron deficiency without providing excess.

Journal ArticleDOI
TL;DR: The nonlinear nature of the relationship between dose and serum concentration suggests that theophylline dosage adjustment should be performed cautiously using small increments.


Journal ArticleDOI
TL;DR: The hospital charts of 274 infants under 6 months of age with culture-proved respiratory syncytial virus infections were reviewed, and Fifty-six infants demonstrated apnea in association with RSV infection.


Journal ArticleDOI
TL;DR: Children with asplenia syndrome who survived the first month of life were at greater risk of dying from sepsis than from their heart disease, and prophylactic antibiotics be administered to children with congenital absence of the spleen, commencing at three months of age, to be continued indefinitely.

Journal ArticleDOI
TL;DR: Three infants are presented who had withdrawal symptoms after prolonged, intrauterine exposure to diazepam; one infant died at six weeks of age; death was attributed to the sudden infant death syndrome.

Journal ArticleDOI
TL;DR: The differential white cell count appears to be a useful tool for screening infants presenting with respiratory distress in the first 48 hours of life and for separating early-onset group B streptococcal disease from other causes of neonatal respiratory distress.

Journal ArticleDOI
TL;DR: Clinical need for reliable sustained-release preparations of theophylline for children who are receiving continuous therapy for children with chronic asthma is supported in order to avoid unrealistically short dosing intervals.

Journal ArticleDOI
TL;DR: Evidence from these two cases and a review of the literature indicate that congenital skin defects of other body areas, as represented by these two children, is a specific pattern of malformation distinct from isolated small congenITAL skin defects involving the vertex of the scalp.

Journal ArticleDOI
TL;DR: Among the early manifestations of the disease, nasal obstruction and an adenoidal expression were common and the facial appearance of the patient is characteristic.

Journal ArticleDOI
TL;DR: Well, appropriate-for-gestational age, low-birth-weight infants were divided into three gestational age groups and assigned randomly within each age group to one of five feeding regimens, offering further evidence for the limited capacity of the low- Birth-weight infant to catabolize tyrosine.

Journal ArticleDOI
TL;DR: Among 302 neonates passively addicted to narcotics, 18 had seizures that were attributed to withdrawal, and paregoric was more effective than was diazepam in controlling and preventing these seizures once they occurred.

Journal ArticleDOI
TL;DR: In this paper, a serologic survey of 127 children with various rheumatic diseases confirmed the specificity of high titer of speckled ANA and antibodies to RNP for mixed connective tissue disease in children.

Journal ArticleDOI
TL;DR: A persistent association of developmental outcome with hyperbilirubinemia was found over and above the variation of maturity within the birth weight/gestational age categories.


Journal ArticleDOI
TL;DR: Two male siblings with nephrotic syndrome, nerve deafness, and hypoparathyroidism are described and it is suggested that this may be the first recorded association of familial nephrosis, nerve hearing loss, and parathyroid glands.

Journal ArticleDOI
TL;DR: It is the purpose of this report to review recent concepts regarding the pathogenesis of neonatal apnea and to propose a treatment schema based on counteracting the supposed physiologic aberrations with a minimum of risk.