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Showing papers in "The Journal of Pediatrics in 1994"


Journal ArticleDOI
TL;DR: It is concluded that intensive therapy effectively delays the onset and slows the progression of diabetic retinopathy and nephropathy when initiated in adolescent subjects; the benefits outweigh the increased risk of hypoglycemia that accompanies such treatment.

1,454 citations


Journal ArticleDOI
TL;DR: It is concluded that many patients with Wiskott-Aldrich syndrome have an atypical presentation and that a panel of diagnostic tests is often required to establish the diagnosis.

599 citations


Journal ArticleDOI
TL;DR: It is concluded that OPT rarely progress during the next few years in children with neurofibromatosis type 1 once the OPT have been discovered and the utility of screening neuroimaging for OPT in symptom-free children with NF-1 appears very limited.

462 citations


Journal ArticleDOI
TL;DR: The growth curves generated in the 1960s and 1970s are valid for children of the 1990s and most children growing < 5 cm/yr (a commonly used threshold rate) will not have an endocrine disorder.

381 citations


Journal ArticleDOI
TL;DR: Puberty has varying effects on skeletal mineralization depending on skeletal site; trabecular bone is apparently more sensitive to changing hormone concentrations and physical activity was associated with more rapid mineralization in prepubertal children.

380 citations


Journal ArticleDOI
TL;DR: Treatment with beta-lactamase-stable agents does not increase resolution of acute symptoms or middle ear effusion; initial therapy should be guided by considerations of safety, tolerability, and affordability, and not by the theoretical advantage of an extended antibacterial spectrum.

348 citations


Journal ArticleDOI
TL;DR: Results suggest that human herpesvirus 7 is one of the causative agents of exanthem subitum, and five of seven patients had seroconversion to HHV-7 just after having typical signs and symptoms ofExanthemSubitum.

335 citations


Journal ArticleDOI
TL;DR: It is concluded that SEE decreases and weight improves after resolution of OSAS and it is speculated that the poor growth seen in some children with OSAS is secondary to increased caloric expenditure caused by increased work of breathing during sleep.

334 citations


Journal ArticleDOI
TL;DR: The results indicate that mothers with insulin-dependent diabetes who maintain good control during pregnancy can expect to have infants who are neurodevelopmentally normal; mothers whose diabetes is less well controlled may have infants with less optimal neurodevelopment.

331 citations


Journal ArticleDOI
TL;DR: It is concluded that unidentified patients with this disorder have a significant risk of sudden death in early childhood and that survivors have asignificant risk of developmental disability and chronic somatic illness.

265 citations


Journal ArticleDOI
TL;DR: The incidence of acute rheumatic fever has been declining since the peak of the outbreak in 1985 but is continuing in the intermountain area at rates comparable to those of the 1960s.

Journal ArticleDOI
TL;DR: For urine specimens obtained by catheter, it is believed that urinary tract infection is best defined by both a leukocyte count > or 10/mm3 and a CFU count < or = 50,000/ml, which almost always discriminates among true urinary tract infections, bacteriuria resulting from contamination of the urine specimen, and asymptomatic bacteriuri.

Journal ArticleDOI
TL;DR: It is demonstrated that there is no significant difference in response between low and high doses of inhaled NO and that this treatment may prevent the need for ECMO in some infants referred for this therapy, especially in infants with pulmonary hypertension.

Journal ArticleDOI
TL;DR: It is found that cortical scintigraphy is more sensitive than ultrasonography in detecting renal changes, and it is believed that it should be added to the initial examination of children with suspected pyelonephritis.

Journal ArticleDOI
TL;DR: Growth rate and standardized height were significantly increased in growth-retarded prepubertal children with chronic renal failure when rhGH was used and may facilitate the achievement of the inherent growth potential of such children.

Journal ArticleDOI
TL;DR: HFO is a safe and effective rescue technique in the treatment of neonates with respiratory failure in whom conventional ventilation fails, and there were no differences between the two groups with respect to outcome, need for extracorporeal membrane oxygenation, or complications.

Journal ArticleDOI
TL;DR: With the use of strict screening criteria, a substantial number of febrile one-to-two-month-old infants can be cared for safely as outpatients and without antibiotics.

Journal ArticleDOI
TL;DR: Children who have multiple conditions of a chronic nature, even if few in number, have increased morbidity across a variety of measures.

Journal ArticleDOI
TL;DR: It is concluded that cuffed endotracheal intubation is not associated with an increased risk of postextubation stridor or significant long-term sequelae and two patients who previously had insertion of a cuffed ETT subsequently received tracheostomies for the primary purpose of long- term mechanical ventilation unrelated to any problem with the upper airway.

Journal ArticleDOI
TL;DR: It is concluded that inhaled NO acutely improves oxygenation and lowers pulmonary vascular resistance without causing adverse hemodynamic effects in severe hypoxemic respiratory failure in pediatric patients.

Journal ArticleDOI
TL;DR: It is concluded that plasma interleukin-6 is a more reliable indicator of bacterial sepsis and NEC than plasma TNF and may identify infants who might benefit from immunotherapeutic strategies.

Journal ArticleDOI
TL;DR: Logistic regression with a perinatal and a 5-year time category showed that the most predictive factors for special education were developmental delay, neuromotor and speech/language function, inattention and hyperactivity score, total problem score, and reported school results at the age of 5 years.

Journal ArticleDOI
TL;DR: It is concluded that partial albinism with immunodeficiency (Griscelli syndrome) can be differentiated from Chédiak-Higashi syndrome by pathognomonic histologic features.

Journal ArticleDOI
TL;DR: There is an ongoing need to improve the accuracy and validity of currently available measures of biologic activity and clinical efficacy in CF, especially in the younger population.

Journal ArticleDOI
TL;DR: Behavior changes in irritability, restlessness, and sleep disturbance are associated with the ingestion of tartrazine in some children.


Journal ArticleDOI
TL;DR: At early ages (7- to 11-year-old children), fatness was related to risk factors for cardiovascular disease and diabetes.

Journal ArticleDOI
TL;DR: Nine obese children were referred to the liver disease unit because of asymptomatic, long-standing hyperaminotransferasemia of unknown origin, and the hepatic abnormalities of the complaint patients showed a prompt and persistent improvement that paralleled the loss of excess weight.

Journal ArticleDOI
TL;DR: Iron-fortified formula significantly reduced iron deficiency in a high-risk group of infants and prevented a decline in psychomotor development quotients, suggesting this effect may be transient, and its long-term significance needs further study.

Journal ArticleDOI
TL;DR: It is concluded that NF 1 is associated with a significantly lower Full Scale IQ, multifocal cognitive deficits (Verbal IQ, Judgment of Line Orientation score), reading disability, and neuromotor deficit.