Journal•ISSN: 0960-0760
The Journal of Steroid Biochemistry and Molecular Biology
Elsevier BV
About: The Journal of Steroid Biochemistry and Molecular Biology is an academic journal published by Elsevier BV. The journal publishes majorly in the area(s): Estrogen & Estrogen receptor. It has an ISSN identifier of 0960-0760. Over the lifetime, 6838 publications have been published receiving 259708 citations. The journal is also known as: Journal of Steroid Biochemistry and Molecular Biology.
Papers published on a yearly basis
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TL;DR: Although many questions remain to be answered, it is becoming increasingly apparent that exposure to BPA is ubiquitous and that the effects of this endocrine disruptor are complex and wide-ranging.
1,076 citations
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TL;DR: It has been hypothesized that endocrine disruptors may play a role in the decrease in the quantity and quality of human semen during the last 50 y, as well as in the increased incidence of testicular cancer and cryptorchidism in males and breast cancer incidence in both females and males in the industrialized word.
938 citations
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TL;DR: This work proposes that selective estrogen receptor modulator (SERM) complexes with ERbeta and with truncated ERalpha derivatives use their DNA binding domain to titrate histone deacetylase (HDAC)-repressor complexes away from the Jun/Fos coactivator complex, thereby allowing unfettered activity of the coactivators.
921 citations
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TL;DR: This review focuses on the mechanisms and modes of action by which EDCs alter hormone signaling, and includes brief overviews of select disease endpoints associated with endocrine disruption.
888 citations
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TL;DR: The importance of this unique aspect of the tissue-specific regulation of aromatase expression lies in the fact that the low circulating levels of estrogens which are observed in postmenopausal women have little bearing on the concentrations of estrogen in, for example, a breast tumor, which can reach levels at least one order of magnitude greater than those present in the circulation, due to local synthesis within the breast.
845 citations