Showing papers in "The Journal of Steroid Biochemistry and Molecular Biology in 2001"

TL;DR: Teleost fish are characterized by exceptionally high levels of brain estrogen biosynthesis when compared to the brains of other vertebrates or to the ovaries of the same fish, and goldfish and zebrafish have utility as complementary models for understanding the molecular basis and functional significance of exaggerated neural testosterone biosynthesis.

TL;DR: The different characteristics of the multiple types of human 17beta-HSD are analyzed - types 1, 3, 5 and 7 catalyze the reductive reaction, while types 2, 4 and 8 catalyzeThe oxidative reaction, and it is noteworthy that rat type 6 17 beta- HSD also catalyzes the reaction in the oxidative direction.

TL;DR: It is concluded that tibolone acts as a tissue-specific compound by mediating its effects via steroid receptors and enzymatic pathways, and avoids stimulation of the endometrium and breast tissue.

TL;DR: It seems that direct repeat elements can be the determinants of the AR-specificity, as it is demonstrated that the AR binds direct repeats of 5'-TGTTCT-3'-like sequences in gel retardation assays as well as in transfection experiments.

TL;DR: This is the first study to indicate that glabrene, an isoflavene exerted varying degrees of ER agonism in different tissues, and both showed an ER-dependent growth-promoting effect at low concentrations, and ER-independent antiproliferative activity at concentrations >15 microM.

TL;DR: Tandem analysis of Cyp19a and cyp19b promoters in living zebrafish embryos can be a useful approach for identifying cis-elements and cellular factors involved in the correct tissue-specific, spatial, temporal and estrogen regulated expression of aromatase genes during CNS and gonadal development.

TL;DR: This low response rate to second line treatment suggests that tumors of most patients were no longer sensitive to the effects of estrogen, and suggests that aromatase inhibitors may offer better control of tumor growth than this antiestrogen.

TL;DR: An important role for estrogen in the maintenance of lipid homeostasis in both males and females is demonstrated, and the consequences of estrogen deficiency on accumulation of adipose depots in male and female ArKO mice are examined.

TL;DR: It is demonstrated here that AA in hypothalamic homogenates is rapidly down-regulated by exposure to conditions that enhance protein phosphorylation (addition of Ca2+, Mg2+, ATP).

TL;DR: The ovarian phenotype of the ArKO mouse can be attributed to the altered hormonal environment brought about by the absence of aromatase and the failure of androgens to be converted to oestrogens in the presence of elevated gonadotropins.

TL;DR: An abnormality in endometriosis, i.e. deficient 17beta-hydroxysteroid dehydrogenase (17beta-HSD) type 2 expression, impairs the inactivation of estradiol to estrone, results in local production of estrogen, which induces PGE2 formation and establishes a positive feedback cycle.

TL;DR: The data suggest that compounds can be generated that are TR-selective and that compounds with this property and/or that exhibit selective uptake, might have clinical utility as selective TR modulators.

TL;DR: The preliminary studies implicate the altered expression of several estrogen-regulated genes, and suggest resistance to antiestrogens is likely to be a multigene phenomenon, involving a network of interrelated signaling pathways.

TL;DR: Data suggest 11beta-HSD1 may play an important role in regulating inflammatory responses in the artery wall and lung after stimulation with IL-1beta or TNFalpha, indicating the regulatory effect is not limited to vascular smooth muscle.

TL;DR: Characterization of the newly described human hydroxysteroid sulfotransferase SULT2B1 isoforms shows that these enzymes are selective for the sulfation of 3 beta-hydroxysteroids, such as pregnenolone, epiandrosterone, DHEA, and androstenediol.

TL;DR: The high content of isoflavones as well as the higher transactivational potency for ER beta than ER alpha make these extracts interesting candidates for HRT.

TL;DR: Letrozole is consistently 10-30 times more potent than anastrozoles in inhibiting intracellular aromatase in intact rodent cells, normal human adipose fibroblasts and human cancer cell lines, and whether these differences are seen in the clinical setting will have to await the results of clinical trials which are currently in progress.

TL;DR: The results show that ArKO mice show the effects of estrogen deficiency on bone growth, mass, metabolism, microarchitecture and the hematopoietic microenvironment.

TL;DR: In situ assays demonstrate that new aromatase inhibitors such as anastrozole, exemestane and letrozoles have profound effects on the local endocrinology within the postmenopausal breast, these being compatible with the clinico-pathological changes which occur with treatment.

TL;DR: It is suggested that the rutin effects on molting in insects are most likely due to the metabolites, luteolin or quercetin, while tomatine acts via a non-EcR pathway.

TL;DR: Surprisingly, a series of experiments suggested that MAP kinase increased in hypersensitive cells as a result of estrogen activation via a non-genomic pathway and suggest that the cell membrane ER pathway may be responsible for upregulation ofMAP kinase and hypersensitivity in cells adapted to estradiol deprivation.

TL;DR: It is indicated for the first time that the expression of the human estrogen receptor beta (ER beta) gene is regulated, at least in part, by the multiple untranslated first exons and promoters system.

TL;DR: Evidence is reviewed that supports the conclusions that the LBD of the DBP, VDR(mem) and VDR (nuc) each select as their preferred ligand a unique shape of the conformationally flexible 1alpha,25(OH)(2)D(3).

TL;DR: FC-1271a appears to exert anti-estrogenic effects dependent on estrogen receptor positivity in vitro and in vivo on the growth of MCF-7 cells.

TL;DR: Future studies of in situ estrogen formation in brain in the primate model are important for understanding the importance of aromatase not only for reproduction, but also for neural functions such as memory and cognition that appear to be modulated by estrogens.

TL;DR: The annual reproductive cycle of oyster Crassostrea gigas depends on environmental factors, but its endocrine regulations are still unknown, and sexual steroids play important roles at this level in vertebrates, and some estradiol effects have been described in invertebrates such as bivalve mollusks.

TL;DR: The findings on ERbeta reveal a ligand-independent activation pathway which involves growth factor-mediated phosphorylation of ERbeta activation function-1 (AF-1) and subsequent recruitment of SRC-1 independently of the presence of estrogens.

TL;DR: The results suggest that the ER on the plasma membrane of MCF7 cells is similar, but not identical to its intracellular counterpart, and propose that the observed mER actively participates in the estrogen-mediated proliferation of MCf7 cells.

TL;DR: It is proposed that activated CREB is recruited to estrogen responsive genes by an ER--coactivator complex containing proteins such as CREB binding protein (CBP) and that the interaction of CREB with ER may assist in stabilizing its interaction with CBP and in promoting estrogen-ER and PKA transcriptional synergy.

TL;DR: In the bank-vole testis, a synchronisation between a fully developed spermatogenesis and a strong positive immunoreactivity for both P450arom and estrogen receptor (ERbeta) in sperMatids is evidenced and evidence an additional site for estrogen production within the testis evidence enlightenments on the hormonal regulation of male reproductive function.