Showing papers in "The Journal of Steroid Biochemistry and Molecular Biology in 2013"

TL;DR: The skin can be defined as an independent steroidogenic organ, whose activity can affect its functions and the development of local or systemic inflammatory or autoimmune diseases.

TL;DR: A systematic review of clinical studies investigating the association between vitamin D deficiency and susceptibility to acute respiratory infection in humans found results from randomised controlled trials were conflicting, reflecting heterogeneity in dosing regimens and baseline vitamin D status in study populations.

TL;DR: The present review is an update on some of the steroidal leads obtained during past 25 years, various steroid based enzyme inhibitors, antiestrogens, cytotoxic conjugates and steroidal cytot toxic molecules of natural as well as synthetic origin have been highlighted.

TL;DR: The response to vitamin D is dependent on body weight and women with BMI <25kg/m(2) develop much higher levels of serum 25OHD after vitamin D supplementation compared to those with BMI of >25kg / m(2), and in this group smaller doses of vitamin D used should be used.

TL;DR: The structures of oestrogen-metabolising enzymes are discussed and compared and the impact of structure on inhibitor design is briefly mentioned.

TL;DR: The role of 17α-hydroxylase/17-20 lyase (CYP17A1) in the production of dehydroepiandrosterone and back-door pathways of dihydrotestosterone biosynthesis is analyzed.

TL;DR: In this article, the authors assess the safety and health effects of vitamin D supplementation during pregnancy, and propose a method to assess the effect of supplementing pregnant women with vitamin D during pregnancy.

TL;DR: The evidence that supports the vital role of AKR1C3 in CRPC is examined and recent developments in the discovery of potent and selective AKR 1C3 inhibitors are examined.

TL;DR: Novel findings are focused on, which suggest that DEHP exerts more complex and broader disruptive effects on the endocrine system and metabolism than previously thought.

TL;DR: It is suggested that the presence of AR in tumour is either benign or predicts better survival and further translational investigations regarding the mechanisms of androgen action in TNBC are required to explain this discrepancy between clinical and basic studies.

TL;DR: An analysis of changes in sequence and structure of vertebrate GR and MR is reviewed, identifying changes in these receptors in skates and lobe-fined fish important in allowing aldosterone to act as an agonist at epithelial MR and glucocorticoid specificity for GR.

TL;DR: Continuing studies of the etiology of nutritional rickets will provide evidence to underpin guidelines for the prevention and treatment of rickets world-wide, reports from Africa and Asia suggest.

TL;DR: Novel approaches to vitamin D fortification of food in both countries now include "bio-addition" in which food staples are fortified through the addition of another vitamin D-rich food to animal feed during production, or manipulation of food post-harvest or pre-processing.

TL;DR: It is demonstrated that some aspects of steroid hormone research are well characterized, while other aspects such as functional analyses of enzymes, steroid hormone elimination, or the impact of steroid hormones on embryonic development or sex differentiation have not been extensively studied and are poorly understood.

TL;DR: This article strives for a better comprehension of the mutual reaction between these steroid hormones and the two major glial cell types involved in the maintenance of brain homeostasis, astroglia and microglia, during acute traumatic brain injuries such as stroke and hypoxia.

TL;DR: This data indicates that 11β-HSD1 inhibition reduces inflammation in obesity or atherosclerosis and an increased angiogenic response may underlie some of the benefits.

TL;DR: The interplay between vitamin D and CYP3A4 provides new insights into the authors' understanding of how enzyme induction can contribute to vitamin D deficiency.

TL;DR: Female hearts are generally less susceptible to acute ischemic damage and associated arrhythmias, and generally are more resistant to stress-induced hypertrophy and heart failure, attributed to the cardioprotective actions of estrogen, but more recent data show that testosterone can also improve acute post-ischemic outcomes and facilitate myocardial function and survival in chronic post-infarction.

TL;DR: Ambient UVR levels and time in the sun were of prime importance but it is nonetheless important to include the contribution of genetic factors when considering sun exposure effects.

TL;DR: UpLC-MS/MS analyses of 11OHA4 metabolism in LNCaP androgen-dependent prostate cancer cells, identified the 5α-reduced metabolite as well as 11-ketoandrostenedione and 12-ketotestosterone, with the latter indicating conversion by 17β-hydroxysteroid dehydrogenase.

TL;DR: This review highlights recent findings on the cross-talk between a member of the GPCR family, the G protein-coupled estrogen receptor 1 (GPER), and two main growth factor receptors like EGFR and insulin-like growth factor-I receptor (IGF-IR).

TL;DR: The results indicate that VDR is involved in 1,25D-induced rapid events related to survival/proliferation responses in skeletal muscle cells, providing relevant information on the mechanism of initiation of the non-genomic hormone signal.

TL;DR: The results indicate that Ad activates the AMPK signaling pathway and mediates lipid metabolism in bovine hepatocytes cultured in vitro by promoting lipid oxidation, suppressing lipid synthesis and reducing hepatic lipid accumulation.

TL;DR: Prasterone is a promising physiological and attractive solution to treating VVA symptoms and remains within the normal postmenopausal range following daily intravaginal administration of 6.5mg prasterone, confirming the absence of any biologically relevant systemic exposure to estrogens and androgens.

TL;DR: Evaluating the potential of ultra-high pressure liquid chromatography coupled with a new generation high resolution quadrupole time-of-flight mass spectrometer to investigate the steroid metabolism after transdermal and oral T administration found no traditional markers of T misuse could detect doping after topical administration of T, while the detection window was short after oral TU ingestion.

TL;DR: Evidence is provided that active vitamin D is an ER stress reliever that may have a role in atherosclerotic plaque regression and suppression of ER stress by 1,25(OH)2D decreases monocyte infiltration and reverses atherogenic cholesterol metabolism in previously differentiated, vitamin D-deplete macrophages.

TL;DR: It is demonstrated that BV-2 microglia cells respond to hypoxia by enhanced pro-inflammatory cytokine secretion and reduced phagocytic activity, which is prevented by sex steroids resulting in a switch of Bv-2 cells from a pro- inflammatory to a more anti-inflammatory phenotype.

TL;DR: A comparative genome analysis of Mycobacterium spp.

TL;DR: 25-OHD3 could improve diabetic periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in the gingival epithelium, and may also provide a potential therapy for the patients with this disease.

TL;DR: A clearer understanding of the varied mechanisms by which vitamin D directly and indirectly influences mineral bone status are required to support evidence-based recommendations for vitamin D supplementation to reduce the risk of fractures.