Showing papers in "The Journal of Urology in 2016"

TL;DR: The intensity and scope of care for NMIBC should focus on patient, disease, and treatment response characteristics, and a risk-stratified approach categorizes patients into broad groups of low-, intermediate-, and high-risk.

TL;DR: This Guideline is intended for use in conjunction with the individual patient's treatment goals, and in all cases, patient preferences and personal goals should be considered when choosing a management strategy.

TL;DR: In patients with intermediate to high risk prostate cancer preoperative lymph node staging with (68)Ga-PSMA-PET proved to be superior to standard routine imaging, and has the potential to replace current standard imaging for this indication if confirmed by prospective studies.

TL;DR: Comparative studies demonstrated similar cancer specific survival across management strategies, with some differences in renal functional outcomes, perioperative outcomes and postoperative harms that should be considered when choosing a management strategy.

TL;DR: Prostate cancer patients with a prior negative biopsy who has persistent clinical suspicion for prostate cancer and who is under evaluation for a possible repeat biopsy are advised to implement quality assurance programs to monitor targeted biopsy results.

TL;DR: D diagnostic accuracy was generally high for biopsy of localized renal masses with a low complication rate, but the nondiagnostic rate and negative predictive value were concerning.

TL;DR: An updated review of the current diagnosis and management strategies for renal angiomyolipoma and trials of everolimus for patients with tuberous sclerosis complex suggest that this agent may be safe and effective in treating angiomeolipomas with mTOR inhibitors.

TL;DR: These data support the use of active surveillance in low risk and intermediate risk cases of Gleason 6 but not Gleason 7 prostate cancer and suggest Multiparametric magnetic resonance imaging and novel biomarkers might be vital in detecting favorable Gle Mason 7 disease.

TL;DR: Convective water vapor thermal therapy provides rapid and durable improvements in benign prostatic hyperplasia symptoms and preserves erectile and ejaculatory function.

TL;DR: Radioligand therapy with (177)Lu-PSMA-I&T appears to be safe and active in heavily pretreated patients with metastatic castration resistant prostate cancer.

TL;DR: Positive surgical margins after partial nephrectomy increase the risk of disease recurrence, primarily in patients with adverse pathological features.

TL;DR: In men with an abnormal prostate specific antigen/digital rectal examination, multiparametric magnetic resonance imaging detected significant prostate cancer with an excellent negative predictive value and moderate positive predictive value.

TL;DR: Proximal hypospadias remains challenging, regardless of the technique utilized for its repair, and staged repair accomplished better results than both TIP and DIG techniques, despite being performed in the most unfavorable cases.

TL;DR: Most men remain on active surveillance at 5 years without adverse reclassification or adverse pathology at surgery, supporting the need for approaches that improve the prediction of this outcome.

TL;DR: In select men with localized prostate cancer and visible magnetic resonance imaging lesions focal laser ablation has an acceptable morbidity profile and is associated with encouraging short-term oncologic outcomes.

TL;DR: This updated meta-analysis of retrospective cohort studies demonstrated that robotic partial nephrectomy confers a superior morbidity profile compared to laparoscopic partial ne phrectomy in most of the examined perioperative outcomes.

TL;DR: Early prospective data suggest that current criteria result in a high false-positive rate that lowers the cancer detection rate, and stricter criteria may be needed in the future to decrease false-positives and increase the cancer Detection rate for PI-RADS scores of 3, 4 and 5.

TL;DR: PBRM1 and BAP1 expression identified 4 clinical subgroups of patients with clear cell renal cell carcinoma who had divergent clinical outcomes and did not add independent prognostic information to the SSIGN score.

TL;DR: Sarcopenia is a significant prognostic factor in metastatic renal cell carcinoma and the integration of sarcopenia into the Memorial Sloan Kettering Cancer Center risk model improved the c-index.

TL;DR: Comparisons of multiparametric magnetic resonance imaging and prostate specific membrane antigen positron emission tomography of the prostate with whole mount ex vivo prostate histopathology determine the true sensitivity and specificity of these imaging modalities for detecting and locating tumor foci within the prostate.

TL;DR: Sarcopenia is independently associated with cancer specific mortality and all cause mortality after radical nephrectomy for renal cell carcinoma and the importance of assessing skeletal muscle index for risk stratification, patient counseling and treatment planning is underscored.

TL;DR: The new resolution of the micro-ultrasound platform paired with the PRI-MUS protocol shows promise for real-time visualization of suspicious lesions and targeting of biopsies.

TL;DR: The female workforce in urology is characterized compared to that of men with regard to income, workload and job satisfaction and female urologists are significantly less compensated compared to male urology after adjusting for several factors likely contributing to compensation.

TL;DR: Low intensity shock wave treatment is effective even in patients with severe erectile dysfunction who are PDE5i nonresponders, and longer followup is needed to establish the place of low intensity shock waves treatment in these challenging cases.

TL;DR: Active surveillance appears safe in patients at low risk and in select patients at intermediate risk, particularly those with Gleason score 6 and prostate specific antigen greater than 10 ng/ml, particularly in patients with elements of Gleason pattern 4 on diagnostic biopsy.

TL;DR: Response rates and survival are poor after second line chemotherapy for advanced or metastatic urothelial carcinoma and novel biologically targeted drugs as monotherapy or as part of a combination with conventional cytostatics are urgently needed.

TL;DR: Focal laser ablation of the prostate is feasible and safe in men with intermediate risk prostate cancer without serious adverse events or changes in urinary or sexual function at 6 months.

TL;DR: Bioinformatic analysis performed on a broad panel of cancers of nonkidney origin suggests that disturbed expression of genes related to extracellular matrix and adhesion may be a universal feature of cancerous progression.