Showing papers in "The Lancet in 1972"

TL;DR: Two young unrelated girls with similar but not identical manifestations of immunological deficiency were found to have no measurable adenosine-deaminase (A.D.A.) enzyme activity in their red blood-cells, suggesting they may be heterozygous, and their affected children homozyguous, for a mutant A.A.A.'s gene.

TL;DR: Considering manic-depressive disorders and related phenomena from the viewpoint of cholinergic-adrenergic balance, or conceptualising behaviour as having both adrenergic andcholinergic components, provides a framework for understanding the affective disorders.

TL;DR: In the persistent vegetative state (PWS) as mentioned in this paper, patients are in a state where their response is limited to primitive postural and reflex movements of the limbs, and they never speak.

TL;DR: It is suggested that dietary fibre has a role in the prevention of certain large-bowel and other diseases which have become prevalent in Western countries.

TL;DR: In a nine-year follow-up of 3168 men in the Stockholm prospective study, the occurrence of new events of ischaemic heart-disease (I.H.D.) has been related to findings at the initial examination.

TL;DR: Embryonal carcinoma of the testis was detected in two infertile men in whom testicular biopsies had revealed an abnormal seminiferous epithelium with atypical germ cells.

TL;DR: Recording of pattern-evoked responses is a useful objective test for residual optic nerve damage in patients with unilateral optic neuritis and healthy subjects.

TL;DR: This work suggests that joints can wear out by repetitive impulsive loading, rather than by rubbing, and proposes a new mechanistic approach compatible with the pathology of and clinical experience with the disease.

TL;DR: Results suggest that amniotic-fluid-A.F.P. measurements will be valuable in the early antenatal diagnosis of anencephaly and spina bifida and will enable termination of these pregnancies.

TL;DR: Ten euthyroid women with unipolar depression were treated with a single injection of thyrotropin-releasing hormone (T.R.H.) and a single injections of saline in a double-blind, crossover comparison to cause a prompt, brief improvement in depression.

TL;DR: The use of the cholesterol-lowering diet was associated with considerably and significantly reduced mortality from C.H.D. and other causes and total mortality was consistently lower on this diet, although the differences were too small for statistical significance.

TL;DR: The findings in this study are consistent with the hypothesis that Q.M.N.N is an immunologically mediated disorder initiated by quartan malarial infection and which, once established, pursues a progressive course.

TL;DR: It is suggested that the competence of the cell-mediated (T-lymphocyte-dependent) immune system would decide whether the infection is self-limited or persists with varying degrees of liver damage.

TL;DR: All samples of seminal fluid from thirty-one adult male patients who had received cyclophosphamide showed low sperm-counts or azoospermia, and preliminary studies suggest that cycloph phosphamide may also cause ovarian damage.

TL;DR: The data suggest that irradiation for mammary carcinoma leads to a long-lasting lymphopenia which mainly is a selective T-lymphocyte lymph Openia, which may be relevant for the development of distant metastases.

TL;DR: It is suggested that vaso dilator therapy, by reducing left ventricular afterload, can improveLeft ventricular performance in patients with acute myocardial infarction, and may be a rational approach to the management of patients with heart-failure, pulmonary œdema, or early shock.

TL;DR: It is shown that major congenital malformations occurred in their children with twice the expected frequency, and, while anticonvulsant drugs may have a teratogenic action mediated by interference with folic-acid metabolism, suchTeratogenic activity is likely to be influenced by hereditary and environmental factors.

TL;DR: The administration of haematoporphyrin followed by light therapy proved lethal to glioma cells in culture and produced massive destruction of porphyrIn-containing gliomas transplanted subcutaneously in rats.

TL;DR: Gross changes in free sulphydryl groups in hair keratin probably explain the kinky hair, and treatment of Menkes' syndrome may become possible as a result of these findings.

TL;DR: The cavitation of syringomyelia may be produced by cerebrospinal fluid tracking under pressure into the spinal cord from the subarachnoid space along perivascular (Virchow-Robin) spaces.

TL;DR: With the widespread clinical application of androgenic-anabolic steroids (especially their use by athletes), further study is urged to elucidate the precise relationship between this class of drugs and hepatocellular carcinoma.

TL;DR: Five patients with mental depression received thyrotropin-releasing hormone (T.R.H.S.H.) for 3 days as part of a double-blind, cross-over study, and all patients showed improvement in the symptoms of depression.

TL;DR: An analysis of electroencephalographic patterns in thirty-five consecutive patients admitted for the treatment of depression revealed that a single sleep characteristic—the interval between onset of sleep and the start of rapid-eye-movement (R.E.M.M.) sleep—is an objective indicator of depressive disease and correlates inversely with its severity.