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Showing papers in "The Lancet in 1973"


Journal ArticleDOI
TL;DR: The first necropsy performed on a patient with fetal alcohol syndrome disclosed serious dysmorphogenesis of the brain, which may be responsible for some of the functional abnormalities and the joint malposition seen in this syndrome.

2,685 citations


Journal ArticleDOI
TL;DR: The similarity in pattern of malformation noted among 8 unrelated children born to mothers who were chronic alcoholics suggests a singular mode of etiology related to an as yet unknown effect of maternal alcoholism.

2,015 citations


Journal ArticleDOI
TL;DR: Using a standard microcytotoxicity technique of tissue typing, the HL-A 27 antigen was identified in 72 out of 75 patients with classical ankylosing spondylitis and in 3 out of75 controls.

1,607 citations


Journal ArticleDOI
TL;DR: Electrophysiological evidence of associated neural lesions in the neck of patients with carpal-tunnel syndromes or lesions of the ulnar nerve at the elbow is thought to be fortuitous, but rather the result of serial constraints of axoplasmic flow in nerve fibres.

882 citations


Journal ArticleDOI
TL;DR: Electron microscopy of duodenal mucosa from nine children with acute non-bacterial gastroenteritis revealed virus particles in epithelial cells from six patients, believed to have been an important cause of sporadic gastroEnteritis in children in Melbourne during the 3 months of the survey.

870 citations


Journal ArticleDOI
TL;DR: Among 6297 individuals reported to a kidney-transplant registry, the risk of developing lymphoma was about 35 times higher than normal and was derived almost entirely from a risk of reticulum-cell sarcoma, which was 350 times greater than expected.

572 citations


Journal ArticleDOI
TL;DR: It seems likely that oral contraceptives play a role in the development of this lesion, and although benign, the tumour may cause serious or fatal haemorrhage.

555 citations


Journal ArticleDOI

510 citations


Journal ArticleDOI
TL;DR: The 10-year results of a controlled trial of a policy of surgery and a strategy of radical radiotherapy in the treatment of patients with small-cell or oat-celled carcinoma of the bronchus diagnosed preoperatively on bronchial biopsy and thought likely to be operable were given in this paper.

474 citations


Journal ArticleDOI
TL;DR: Family studies showed that the LD-7a character is inherited and not acquired, and the progression of the disease was significantly different from that observed in normal HL-A7 negatives.

468 citations


Journal ArticleDOI
TL;DR: Perfusion experiments on the isolated canine pancreas showed that somatostatin acts directly on the beta cells, causing suppression of the initial and the late sustained insulin release phase.

Journal ArticleDOI
TL;DR: Vigorous exercise apparently protected against rapidly fatal heart attacks and other first clinical attacks of coronary disease alike, throughout middle age, according to a hypothesis that vigorous exercise promotes cardiovascular health.

Journal ArticleDOI
TL;DR: A double-blind prospective trial of prednisone versus azathioprine in the treatment of forty-seven patients with active chronic hepatitis over a 2-year period showed thatprednisone was superior at improving liver function, preventing the development of œsophageal varices, and prolonging survival.

Journal ArticleDOI
TL;DR: Six patients with the watery-diarrhœa syndrome were found to have raised plasma levels and/or high tumour content of vasoactive intestinal peptide (V.I.P.P.), as measured by a specific radioimmunoassay.

Journal ArticleDOI
TL;DR: The histocompatibility antigen HL-A 27 (W 27) was identified in 26 out of 50 patients with acute anterior uveitis, compared with 2 out of50 controls.


Journal ArticleDOI
TL;DR: In 15 patients, antibodies to core appeared in acute viral hepatitis, type B, twelve to twenty weeks after exposure, usually during antigenaemia and well before the appearance of anti-HBAg, and anti-core antibodies were found in all chronic HBAg carriers tested.


Journal ArticleDOI
TL;DR: HL-A 27 (W 27) has been found in 25 out of 33 patients with Reiter's disease, 3 out of 32 patients with non-specific urethritis, and 2 out of33 controls.

Journal ArticleDOI
TL;DR: Recombination experiments indicate that the response can be restored by the addition of T cells, demonstrating the presence of a normally reactive T-cell population in patients with C.L.L., which shows a poor response to mitogens.



Journal ArticleDOI
TL;DR: Almost 1687 cases of pilonidal sinus have been treated by an operation which places resistant skin at the depth of the intergluteal fold, and follow-up suggests a low recurrence-rate.


Journal ArticleDOI
TL;DR: The results suggest that there is a familial trait of hyperlipidaemia in one-third of patients with premature coronary heart-disease, but it is not established whether the trait is inherited or produced by environmental factors.

Journal Article

Journal ArticleDOI
TL;DR: It is concluded that the expected weight of a child of given height is independent of age and largely independent of race.

Journal ArticleDOI
TL;DR: The 2014 Surgeon General’s Report identifies additional cancers that are linked to smoking: cancer of the colon and of the rectum (also called colorectal cancer) and liver cancer.

Journal ArticleDOI
TL;DR: The synthetic growth-hormone-release inhibitory hormone inhibits G.R.R.-I.H. response to insulin-induced hypoglycaemia without affecting the prolactin or corticosteroid responses, but the effects are short-lived.

Journal ArticleDOI
TL;DR: Findings suggest that a brief period of allergen avoidance during a symptomfree vulnerable period might prevent much atopic disease.