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Showing papers in "The Lancet in 1975"


Journal ArticleDOI
TL;DR: In this article, a five-point scale is described, which includes death, persistent vegetative state, severe disability, moderate disability, and good recovery, and duration as well as intensity of disability should be included in an index of ill-health.

6,952 citations


Journal ArticleDOI
TL;DR: The body cholesterol pool increases with decreasing plasma-high-density-lipoprotein (H.D.L.) but is unrelated to the plasma concentrations of total cholesterol and other lipoproteins, and it is proposed that a reduction of plasma-H.H.L.D., is reduced in several conditions associated with an increased risk of future ischaemic heart-disease, by impairing the clearance of cholesterol from the arterial wall.

2,626 citations


Journal ArticleDOI
TL;DR: It is postulated that one major subtype of gastric carcinoma ("intestinal type") is the end- result of a series of mutations and cell transformation begun in the first decade of life, which allows the cell to become autonomous and invade other tissues.

971 citations


Journal ArticleDOI
TL;DR: A parvovirus-like antigen has been found in sera of nine healthy blood-donors and two patients, and can be confused with hepatitis-B antigen both morphologically and serologically.

837 citations



Journal ArticleDOI
TL;DR: A 5-year-old girl with a history of recurrent infection and anaemia has no measurable purine nucleoside phosphorylase (N.P.) activity in her red blood-cells, and it is very likely that this patient's lack of demonstrable N.P. activity is responsible for her syndrome.

787 citations




Journal ArticleDOI
TL;DR: A study of elderly patients who were admitted to hospital with acute illness and extreme self-neglect revealed common features which might be called Diogenes syndrome, suggested that this syndrome may be a reaction late in life to stress in a certain type of personality.

675 citations


Journal ArticleDOI

557 citations


Journal ArticleDOI
TL;DR: Evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon, which is compatible with a bihormonal-abnormality hypothesis.

Journal ArticleDOI
TL;DR: Chemical Pathology laboratory carries out routine and special blood analysis using fully automated or semiautomated analysers to produces higher level of efficiency, accuracy, precision and testing throughput.

Journal ArticleDOI
TL;DR: This study suggests that the Epstein-Barr virus or other viruses triggered the fatal proliferation of lymphocytes and that progressive attrition of T-cell functions allowed uncontrolled lymphoproliferation.

Journal ArticleDOI
JuliaM. Polak1, L. Grimelius1, A.G.E. Pearse1, S.R. Bloom1, A. Arimura1 
TL;DR: Combined immunocytochemical methods, and histological methods for endocrine granules, have demonstrated that the normal pancreatic D cell contains a product with G.I.H.H-like immunoreactivity, which suggests that it may play an important role in digestive physiology.

Journal ArticleDOI
TL;DR: Surprisingly, the convenience of follow-up at work had no effect upon these men's compliance with antihypertensive drug regimens and although men receiving health education learned a lot about hypertension, they were not more likely to take their medicine.


Journal ArticleDOI
TL;DR: A central function of the major histo-compatibility (H) antigens may be to signal changes in self to the immune system, with extreme genetic polymorphism found in the major H antigen systems of higher vertebrates reflecting evolutionary pressure exerted by this immunological surveillance mechanism.

Journal ArticleDOI
TL;DR: Twenty-seven patients with advanced diffuse histiocytic lymphoma (reticulum-cell sarcoma) were treated with combination chemotherapy utilising nitrogen mustard, procarbazine, vincristine, and prednisone and only one has had a recurrence of tumour.


Journal ArticleDOI
TL;DR: In view of the inhibitory effect of somatostatin on both insulin and glucagon secretion, it is suggested that the arrangement of A, B and D cells is important to the normal and pathological functioning of the islet.

Journal ArticleDOI

Journal ArticleDOI
TL;DR: Twenty young adults were studied after a second concussion, and the rate at which they were able to process information was reduced more than in controls who had been concussed only once.



Journal ArticleDOI
TL;DR: This finding suggests that the leukaemic lymphocytes belonged to a single subset of T cells, which responded to allogeneic cells in some of these patients and stimulation by non-specific mitogens was poor in most patients.


Journal ArticleDOI
TL;DR: Plasma exchange offers a new and practical approach to the long-term management of this lethal disorder and may also provide information about the possible reversibility of human atheroma.