Showing papers in "The Lancet in 1978"

TL;DR: Unlike arachidonic acid, eicosapentaenoic acid (C20:5omega-3, E.P.A.) does not induce platelet aggregation in human platelet-rich plasma (P.R.X.A.P.), probably because of the formation of thromboxane A3 (T.G.I3) which does not have platelet aggregating properties.

TL;DR: Blood-pressure was highest mid-morning and then fell progressively throughout the remainder of the day and began to rise again during the early hours of the morning before waking.

TL;DR: Detailed histological analysis of 427 cases entered on the first national Wilms' tumor study revealed that lesions with foci of marked cytological atypism (anaplasia), and those composed predominantly of sarcomatous stroma, were associated with unfavorable outcome.

TL;DR: Seven patients on dialysis with renal failure received transplants from mismatched cadaver donors and were treated with cyclosporin A (CyA), initially as the sole immunosuppressive agent but there was clear evidence of both nephrotoxicity and hepatotoxicity.

TL;DR: One patient died, one had gangrene of the toes, and all have had fine desquamation of affected skin and peeling of palms and soles during convalescence.

TL;DR: The results indicate that steroid treatment is not beneficial and can be detrimental in acute neuropathy of undetermined aetiology in Guillain-Barré syndrome.

TL;DR: The enhancement of reported pain produced by naloxone can be entirely accounted for by its effect on placebo responders, consistent with the hypothesis that endorphin release mediates placebo analgesia for dental postoperative pain.

TL;DR: Three enteropathogenic Escherichia coli strains isolated from outbreaks of infantile diarrhoea and one strain from the "normal" colonic flora of a healthy adult and fed in doses of 10(6), 10(8), and 10(10) organisms in NaHCO3 to adult volunteers gave negative results in sensitive tests for heat-labile (L.T.T.) enterotoxin, invasiveness, and gross fluid accumulation.

TL;DR: The data suggest that opiate withdrawal is due to increased neuronal activity in areas such as the locus coeruleus which are regulated by both alpha-2 adrenergic and opiate receptors.

TL;DR: Findings suggest that P.M.C. results from infection with C. difficile and that previous antibiotic therapy produces susceptibility to infection.

TL;DR: Increased dopamine-receptor sensitivity was present in five patients who had been free of neuroleptic medication for at least 1 year before death, and therefore may be related to the disease process.

TL;DR: In a double-blind trial in which 45 patients with acute schizophrenia took part the alpha-isomer of flupenthixol was found to be significantly more effective than both beta-flupenthIXol (which does not) and placebo, suggesting that the antipsychotic effect occurs in patients with typically schizophrenic illnesses but may be limited to positive symptoms.

TL;DR: Percutaneous transluminal dilatation of a left-sided renal-artery stenosis was done in a 61-year-old patient with hypertension and blood-pressure fell to normal and renal plasma flow increased.

TL;DR: The evidence that aluminium absorption from dialysate causes osteomalacia and encephalopathy is strong enough to justify the expense of treating water by deionisation, reverse osmosis, or both in centres where tap-water aluminium is high.

TL;DR: Isolated glucocorticoid failure associated with achalasia of the cardia is described in two pairs of siblings in separate families, which probably represents a familial disorder of as yet unknown aetiology.

TL;DR: A hypothesis, based on epidemiological and histopathological data, is proposed to account for the aetiology of colorectal adenomas and carcinomas.

TL;DR: The best way to think of the present willingness of computer geeks to rethink the role of emotions in computing is to see it in this larger context, which reflects a new understanding of the place and role of emotion in all aspects of human life, including functions considered essential to intelligence.

TL;DR: The antithrombotic effect of dipyridamole is through phosphodiesterase inhibition and depends on stimulation of platelet cyclic A.M.P. by circulating prostacyclin in the bloodstream.

TL;DR: Hepatitis was transmitted by serum derived from patients with chronic as well as acute hepatitis, strongly suggesting a chronic carrier state for the agent responsible for non-A, non-B hepatitis.

TL;DR: An enkephalin analogue given intravenously to normal subjects raised serum prolactin and growth-hormone levels but lowered serum levels of luteinising hormone, follicle-stimulating hormone, cortisol, and corticotrophin.

TL;DR: A neurological disorder developed after prolonged exposure to nitrous oxide in 15 patients, all but 1 of whom were dentists, and the neurological picture is similar to that of subacute combined degeneration of the spinal cord, and it is possible thatNitrous oxide interferes with the action of vitamin B12 in the nervous system.

TL;DR: It is concluded that the diabetes seen in congenital rubella is due to viral infection of the pancreatic islet cells.

TL;DR: In this paper, the authors added approximately 20 g/day of concentrated dietary fibre from carrot, cabbage, apple, bran, and guar gum to the controlled basal diet of nineteen healthy volunteers.

TL;DR: The results of this study indicate that P.C.V. should be maintained at less than 0·45 and the platelet-count at less-than- 400×10 9 /1 in primary proliferative polycythaemia.