Showing papers in "The Lancet in 1988"

TL;DR: 17,187 patients entering 417 hospitals up to 24 h after the onset of suspected acute myocardial infarction were randomized, with placebo control, between a 1 h intravenous infusion of streptokinase and 1 month of 160 mg/day enteric-coated aspirin.

TL;DR: Investigation for antibodies to a novel type of Chlamydia sp, TWAR, and to chlamydial lipopolysaccharide (LPS) group antigen found they could be a factor in the pathogenesis of cardiovascular diseases.

TL;DR: The results strongly suggest that the newly isolated virus is identical or closely related to HHV-6 and the causal agent for exanthem subitum.

TL;DR: Enterococci associated with cultures obtained from burn patients have been on the increase, worldwide, over the past decade and are now among the four most common nosocomial pathogens in the US and have been called the ‘nosocomial infections of the 1990s’.

TL;DR: Findings seem to explain why sodium retention, hypokalaemia, and hypertension develop in subjects with congenital deficiency of 11 beta-OHSD and those in whom the enzyme has been inhibited by liquorice.

TL;DR: 100 consecutive patients with both duodenal ulcer and Campylobacter pylori infection were followed up to see whether eradication of C pylonori affected ulcer healing or relapse.

TL;DR: Subset analysis showed that patients who had a normal electrocardiogram (ECG) at the time of randomisation had a low case fatality rate and rt-PA was associated with a 24.5% relative reduction in 1 month fatality.

TL;DR: The prevalence of polycystic ovaries (PCO) in normal women of reproductive age was determined by pelvic ultrasound scanning of 257 volunteers who considered themselves to be normal and who had not sought treatment for menstrual disturbances, infertility, or hirsutism, which suggest that PCO in women who consider themselves toBe normal is part of the same clinical spectrum as the classic Stein-Leventhal syndrome.

TL;DR: 121 patients with acute pancreatitis thought to be due to gallstones were randomised to treatment with urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy or with conventional treatment, stratified by predicted severity of the attack according to the modified Glasgow system.

TL;DR: Paradoxical embolism through a patent foramen ovale may be an under-recognised cause of stroke in young adults.

TL;DR: In this article, the relation between urinary albumin excretion rate (AER) and vascular disease was studied in 187 subjects aged over 40 selected from 1084 cases attending a diabetic screening project.

TL;DR: There was a U-shaped relationship between alcohol intake and total mortality and an inverse relationship with cardiovascular mortality, even after adjustment for age, cigarette smoking, and social class.

TL;DR: A genetically reshaped human IgG1 monoclonal antibody (CAMPATH-1H) was used to treat two patients with non-Hodgkin lymphoma and might have an important use in the treatment of lymphoproliferative disorders and additionally as an immunosuppressive agent.

TL;DR: G-CSF administration followingmelphalan reduced the period of neutropenia caused by melphalan and reductions in the number of days of neutrophils following cytotoxic chemotherapy may reduce the morbidity and mortality of chemotherapy.

TL;DR: There seems to be no need for immediate angiography and PTCA in patients with acute myocardial infarction treated with rTPA, with a lower incidence of recurrent ischaemia, bleeding complications, hypotension, and ventricular fibrillation after non-invasive therapy.

TL;DR: Findings indicate that the deleterious effects of abuse can continue to contribute to psychiatric morbidity for many years.

TL;DR: The cost-effectiveness of treating all solar keratoses to prevent the development of SCC is questionable and the risk of malignant transformation of aSolar keratosis to SCC within 1 year was less than 1/1000.

TL;DR: Results provide the first clear indication that NSAID-induced ulcers are preventable, and Mild to moderate, self-limiting diarrhoea was the most frequently reported adverse effect attributed to misoprostol.

TL;DR: The effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on bone-marrow and peripheral-blood progenitor cells was investigated in a three-phase study in 13 patients with sarcoma and may be of clinical importance with regard to facilitating the harvest of peripheral blood progenitors cells for autotransplantation.

TL;DR: Assessment with a five-item clinical symptom scale showed significant improvement during the mexiletine phase compared with the placebo phase, and pain was reduced during mex toiletine but not during placebo, as assessed by a visual analogue rating scale.

TL;DR: The mean plasma level of interleukin 1 beta (IL-1 beta) was significantly higher in 51 patients with rheumatoid arthritis than in 21 healthy controls of similar age and correlated positively with Ritchie joint index, pain score, and erythrocyte sedimentation rate and correlated negatively with haemoglobin concentration.

TL;DR: It is suggested that ddC has activity against HIV in vivo and has a different toxicity profile from that of zidovudine (AZT).

TL;DR: The results show that a CD4-positive T cell clone can lyse HLA class II matched islet cells; this process may be important in the pathogenesis of type 1 diabetes.

TL;DR: In a randomised, double-blind trial 60 patients with left ventricular dysfunction but without clinical evidence of heart failure 1 week after Q wave myocardial infarction were given captopril 25 mg thrice a day, frusemide 40 mg daily, or placebo.

TL;DR: Findings confirm an increased risk of upper gastrointestinal cancer in the polyposis patient, particularly distal to the pylorus, and support an adenoma-carcinoma sequence.