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Showing papers in "The Lancet in 2002"


Journal ArticleDOI
TL;DR: Throughout middle and old age, usual blood pressure is strongly and directly related to vascular (and overall) mortality, without any evidence of a threshold down to at least 115/75 mm Hg.

9,101 citations


Journal Article
TL;DR: Adding simvastatin to existing treatments safely produces substantial additional benefits for a wide range of high-risk patients, irrespective of their initial cholesterol concentrations.

6,614 citations


Journal ArticleDOI
TL;DR: The first World Report on Violence and Health analyses different types of violence including child abuse and neglect, youth violence, intimate partner violence, sexual violence, elder abuse, self-directed violence, and collective violence.

6,086 citations



Journal ArticleDOI
TL;DR: The evidence for adverse effects on health of selected air pollutants is discussed, and it is unclear whether a threshold concentration exists for particulate matter and ozone below which no effect on health is likely.

4,010 citations


Journal ArticleDOI
TL;DR: Patients with Crohn's disease who respond to an initial dose of infliximab are more likely to be in remission at weeks 30 and 54, to discontinue corticosteroids, and to maintain their response for a longer period of time, if inflIXimab treatment is maintained every 8 weeks.

3,870 citations


Journal ArticleDOI
TL;DR: Substantial proportions of global disease burden are attributable to these major risks, to an extent greater than previously estimated.

3,654 citations


Journal ArticleDOI
TL;DR: Research on the mental and physical health sequelae of intimate partner violence is reviewed and increased assessment and interventions for intimate partner Violence in health-care settings are recommended.

3,615 citations


Journal ArticleDOI
TL;DR: In patients with a ruptured intracranial aneurysm, for which endov vascular coiling and neurosurgical clipping are therapeutic options, the outcome in terms of survival free of disability at 1 year is significantly better with endovascular coiling.

3,211 citations


Journal ArticleDOI
TL;DR: Pravastatin given for 3 years reduced the risk of coronary disease in elderly individuals and was extended to elderly individuals the treatment strategy currently used in middle aged people.

3,162 citations


Journal ArticleDOI
TL;DR: A bioinformatics tool was developed and used to identify proteomic patterns in serum that distinguish neoplastic from non-neoplastic disease within the ovary, justifying a prospective population-based assessment of proteomic pattern technology as a screening tool for all stages of ovarian cancer in high-risk and general populations.

Journal ArticleDOI
TL;DR: In view of its rapid development in genetically stable populations, the childhood obesity epidemic can be primarily attributed to adverse environmental factors for which straightforward, if politically difficult, solutions exist.

Journal ArticleDOI
TL;DR: Chemoembolisation improved survival of stringently selected patients with unresectable hepatocellular carcinoma and was associated with a significantly lower rate of portal-vein invasion than conservative treatment.

Journal ArticleDOI
TL;DR: In this paper, epidemiological research was done and used to identify individuals at high risk of disabling fractures, thereby allowing careful allocation of expensive treatments to individuals most in need, which could potentially be as expensive as medical treatment of fractures.

Journal ArticleDOI
TL;DR: LAC is more effective than OC for treatment of colon cancer in terms of morbidity, hospital stay, tumour recurrence, and cancer-related survival.

Journal ArticleDOI
TL;DR: Acarbose could be used, either as an alternative or in addition to changes in lifestyle, to delay development of type 2 diabetes in patients with impaired glucose tolerance.

Journal ArticleDOI
TL;DR: Although hip fracture prediction with BMD alone is at least as good as blood pressure readings to predict stroke, the predictive value of BMD can be enhanced by use of other factors, such as biochemical indices of bone resorption and clinical risk factors.

Journal ArticleDOI
TL;DR: Although there was substantial heterogeneity among studies (especially for antisocial personality disorder), only a small proportion was explained by differences in prevalence rates between detainees and sentenced inmates.

Journal ArticleDOI
TL;DR: Anastrozole is an effective and well tolerated endocrine option for the treatment of postmenopausal patients with hormone-sensitive early breast cancer and longer follow-up is required before a final benefit:risk assessment can be made.

Journal ArticleDOI
TL;DR: Primary preventive interventions should focus on improving the status of women and reducing norms of violence, poverty, and alcohol consumption.

Journal ArticleDOI
TL;DR: Autologous implantation of bone marrow-mononuclear cells could be safe and effective for achievement of therapeutic angiogenesis, because of the natural ability of marrow cells to supply endothelial progenitor cells and to secrete various angiogenic factors or cytokines.

Journal ArticleDOI
TL;DR: Immediate androgen suppression with an LHRH analogue given during and for 3 years after external irradiation improves disease-free and overall survival of patients with locally advanced prostate cancer.

Journal ArticleDOI
TL;DR: A treatment strategy directed at normalisation of the induced sputum eosinophil count reduces asthma exacerbations and admissions without the need for additional anti-inflammatory treatment.

Journal ArticleDOI
TL;DR: An overview of the newer therapeutic interventions employed in the care of the spinal cord injured individual and the theoretical rationale supporting them is presented.



Journal ArticleDOI
TL;DR: Long-term exposure to traffic-related air pollution may shorten life expectancy, and the association between exposure to air pollution and (cause specific) mortality was assessed with Cox's proportional hazards models.

Journal ArticleDOI
TL;DR: Meryon’s observations were neglected for many years for various reasons, and the disorder became eponymously associated with Duchenne in Paris, who detailed the clinical and muscle histology some years later.

Journal ArticleDOI
TL;DR: PVL-producing S aureus strains cause rapidly progressive, haemorrhagic, necrotising pneumonia, mainly in otherwise healthy children and young adults, and has a high lethality rate.

Journal ArticleDOI
TL;DR: The whole genome sequence of MW2, a strain of community-acquired MRSA, was ascertained by shotgun cloning and sequencing and found that it carried a range of virulence and resistance genes that was distinct from those displayed on the chromosomes of extant S aureus strains.