Journal•ISSN: 0040-5930
Therapeutische Umschau. Revue thérapeutique
Hogrefe Verlag
About: Therapeutische Umschau. Revue thérapeutique is an academic journal published by Hogrefe Verlag. The journal publishes majorly in the area(s): Population & Poison control. It has an ISSN identifier of 0040-5930. Over the lifetime, 1915 publications have been published receiving 8551 citations. The journal is also known as: TU & Revue thérapeutique.
Topics: Population, Poison control, Medicine, Heart failure, Transplantation
Papers published on a yearly basis
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TL;DR: Cost-effectiveness is likely associated with surveillance activities within the KISS framework, as these activities will have a beneficial effect on nosocomial infection rates in participating hospitals.
Abstract: Die Krankenhaushygiene hat im Laufe der vergangenen Jahre in Deutschland einen Wandel erfahren. Neben den traditionellen Schwerpunkten der Hygiene nimmt mittlerweile die epidemiologische Arbeit auf dem Gebiet der nosokomialen Infektionen in vielen Spitalern einen wichtigen Platz ein. Zwecks Erfassung dieser Infektionen wurde ein Surveillance-System aufgebaut, welches unter der Abkurzung KISS (Krankenhaus-Infektions-Surveillance-System) bekannt ist. Dieses System baut auf den Erfahrungen und Prinzipien des amerikanischen NNIS (National Nosocomial Infections Surveillance) auf, berucksichtigt aber die lokalen Gegebenheiten und Moglichkeiten der teilnehmenden Spitaler in Deutschland. Mittlerweile stehen sechs KISS-Module zur Auswahl, welche die folgenden Schwerpunkte zur Surveillance umfassen: Intensivstationen, neonatologische Intensivstationen, onkologische Patienten, Patienten mit Venen- oder Harnwegkathetern, sowie ambulante Patienten. Die KISS-Daten konnen fur das Qualitatsmanagement durch die einzelnen ...
554 citations
TL;DR: Most AIHA are caused by warm antibodies and in about fifty percent of these patients an underlying disease such as a lymphoproliferative or an autoimmune disorder can be detected and treatment options are usually supportive and RBC transfusions.
Abstract: Autoimmune hemolytic Anemia (AIHA) is a uncommon but potentially lethal disorder requiring prompt diagnosis and treatment. Diagnosis is based on clinical and laboratory signs of hemolysis and a positive direct antiglobulin test (DAT). AIHA is classified according to the clinical context (primary or secondary) and the characteristics of the auto-antibody (warm vs. cold antibodies). Most AIHA are caused by warm antibodies and in about fifty percent of these patients an underlying disease such as a lymphoproliferative or an autoimmune disorder can be detected. Warm antibodies usually belong to the IgG type and cause hemolysis mainly by Fc-mediated phagocytosis of the IgG-coated red blood cells (RBC) in the spleen. First-line treatment is still based on systemic corticosteroids whereas second-line treatment options include the anti-CD20-antibody rituximab, splenectomy and various immunosuppressive drugs. Cold-agglutinines are less common and usually associated with an underlying disease such as infections (acute) or again lymphoproliferative and autoimmune disorders (chronic). Cold antibodies generally belong to the IgM type and are strong activators of the classical complement pathway which leads to intravascular hemolysis. Treatment options are usually supportive (warming) and RBC transfusions. Paroxysmal cold hemoglobinuria (bithermic IgG antibody) is an important cause of hemolysis in infants and occurs secondary to acute infections.
257 citations
Journal Article•
190 citations
TL;DR: The different methods of long-term monitoring can continuously record EEG and other biosignals for many hours up to several days and allow a direct assessment of seizures and in combination with the video-recorded symptomatology establish a precise diagnosis and follow-up of uncertain seizure disorders in the majority of cases.
Abstract: The electroencephalography (EEG) keeps its essential role in the differential diagnosis of epileptic and non-epileptic seizure disorders and in the classification of the different types of epilepsies and epileptic seizures, mainly due to its unique capability to directly show epileptic malfunction. The routine EEG usually records the EEG between seizures (interictal EEG) and remains a cost effective, highly specific, but not very sensitive method in epileptology. However, a diagnosis based on clinical data and routine EEG alone if often difficult and 20-30% of patients referred to an epilepsy centre due to medical refractory seizures do not have epilepsy. The different methods of long-term monitoring (cable and radio telemetry, ambulatory EEG monitoring) can continuously record EEG and other biosignals for many hours up to several days and allow a direct assessment of seizures (ictal EEG). In combination with the video-recorded symptomatology, these methods establish a precise diagnosis and follow-up of uncertain seizure disorders in the majority of cases. Although technical and personnel investment is relatively high the method used in expert hands is efficient, accepted and cost effective.
153 citations
Journal Article•
TL;DR: The various aspects for the selection of a scale are described and there is as yet no agreed-upon definition of qol nor is there a gold standard measure what complicates the choice of an appropriate assessment scale.
Abstract: Assessment of quality of life (qol) is becoming increasingly important, particularly as an outcome variable in assessing the impact of disease, illness and treatment. However, considerable problems exists in formulation, measurement and interpretation of qol. There is as yet no agreed-upon definition of qol nor is there a gold standard measure what complicates the selection of an appropriate assessment scale. The various aspects for the selection of a scale are described.
149 citations