Thoracic Cancer 

About: Thoracic Cancer is an academic journal published by Wiley. The journal publishes majorly in the area(s): Lung cancer & Medicine. It has an ISSN identifier of 1759-7706. It is also open access. Over the lifetime, 2831 publications have been published receiving 25111 citations.

Comparisons between the National Comprehensive Cancer Network (NCCN) non‐small‐cell lung cancer (NSCLC) Clinical Practice Guidelines (Chinese version), the NCCN original edition, and the European Society for Medical Oncology NSCLC Guidelines in 2009

Abstract: The National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines for various malignant tumors have been widely recognized and followed by global oncologists, in order to promote the standardization of cancer treatment and to provide the best treatment recommendations for cancer patients. However, there are still some differences in different countries and areas based on the specific conditions. In this paper, we compared the differences between NCCN non-small-cell lung cancer Clinical Practice Guidelines (Chinese version), the NCCN original edition, and European Society for Medical Oncology non-small-cell lung cancer guidelines.

Epidemiology of lung cancer in China

Abstract: BACKGROUND: Lung cancer is the most common cancer and the leading cause of cancer death in China Along with socioeconomic development, environmental problems have intensified and the burden of lung cancer continues to increase METHODS: In this study, national cancer registry data was used for evaluating incidence, mortality, time trend, and prediction RESULTS: In China in 2010, 605 900 patients were diagnosed and 486 600 patients died of lung cancer Throughout the last three decades, the mortality of lung cancer has dramatically increased, as shown in national death surveys From 2000 to 2010, age specific incidence of lung cancer increased in most age groups It is estimated that in 2015, the total number of new cases of lung cancer will reach 733 300 CONCLUSIONS: Lung cancer is a serious disease affecting public health and an effective control strategy is needed in China

Epidemiology of lung cancer in China: Epidemiology of lung cancer in China

Abstract: The incidence and mortality rates of lung cancer, the leading cause of cancer death in China, have significantly increased in recent years, and present geographic and gender differences as a result of diversity in lifestyles and socioeconomic development. A series of attribute risk analyses have shown that factors such as smoking, air pollution, and occupational factors are all related to lung cancer. Behavioral intervention, such as smoking cessation and screening, could effectively reduce lung cancer incidence and mortality.

Review of aerobic glycolysis and its key enzymes – new targets for lung cancer therapy

Abstract: Most tumor cells show different metabolic pathways than normal cells. Even under the conditions of sufficient oxygen, they produce energy by a high rate of glycolysis followed by lactic acid fermentation in the cytosol, which is known as aerobic glycolysis or the Warburg effect. Lung cancer is a malignant tumor with one of the highest incidence and mortality rates in the world at present. However, the exact mechanisms underlying lung cancer development remain unclear. The three key enzymes of glycolysis are hexokinase, phosphofructokinase, and pyruvate kinase. Lactate dehydrogenase catalyzes the transfer of pyruvate to lactate. All four enzymes have been reported to be overexpressed in tumors, including lung cancer, and can be regulated by many oncoproteins to promote tumor proliferation, migration, and metastasis with dependence or independence of glycolysis. The discovery of aerobic glycolysis in the 1920s has provided new means and potential therapeutic targets for lung cancer.

Lung cancer incidence and mortality in China, 2010.

Abstract: Background The National Central Cancer Registry (NCCR) is a governmental organization for cancer surveillance affiliated to the Bureau of Disease Control, Ministry of Health, in China. It annually collects cancer registration data from local registries and then analyzes and publishes the results to provide useful information for making anti-cancer policy, program evaluation, and etiology research. At the end of 2012, the NCCR reported cancer statistics for 2009. Methods By mid 2012, 104 population-based cancer registries reported cancer incidence and mortality data, including demographic information, for 2009, to the NCCR. After an evaluation procedure, a total of 72 registries’ data met the criteria, which was then compiled for analysis. Individual lung cancer cases were retrieved from the national database based on the International Classification of Diseases (ICD)-10 topography code as “C33, C34,“ including cancers of the trachea and bronchus. The crude incidence and mortality rates of lung cancer were calculated by gender, age, and location (urban/rural). China's population in 1982 and Segi's population structures were used for age-standardized rates. Results In cancer registration areas in 2009, lung cancer was the most common cancer in China and in urban areas, the second most common cancer in rural areas. It was the leading cause of cancer death both in males and females, urban and rural areas. The incidence and mortality rates of lung cancer were higher in males than those in females, and in urban areas than in rural areas. The age-specific incidence and mortality rates showed that both rates were relatively low for those aged under 50 years, but dramatically increased and reached a peak in the age group of 80–84 years. Conclusion Lung cancer is the most common cancer in China and leading cause of cancer death. Primary and secondary prevention should be carried out in each group, such as tobacco control and early detection.