Showing papers in "Thrombosis Research in 2015"

TL;DR: It is considered tranexamic acid is a drug of great value to reduce almost any kind of bleeding, it is cheap and convenient to use and has principally few contraindications.

TL;DR: The efficacy and safety of LMWH and DOACs for the treatment of VTE in cancer patients may be comparable, according to a network meta-analysis.

TL;DR: Direct oral anticoagulant therapies, including direct anti-Xa and thrombin inhibitors have recently been introduced and may have advantages over vitamin K antagonists such as warfarin as well as their impact on specialty laboratory assays.

TL;DR: An updated overview of the complex coagulopathy associated to malignancy and of recent advances in the thrombotic risk assessment of cancer patients is presented.

TL;DR: Having AIHA, ITP, RA, or SLE, or >1 of these diseases was associated with an increased likelihood of a VTE event and the adjusted hazard ratios for VTE tended to decline over follow-up time.

TL;DR: Rivaroxaban treatment resulted in improved treatment satisfaction compared with enoxaparin/VKA in PE patients, particularly in reducing patient-reported anticoagulation burden.

TL;DR: A case control study comparing TTS in consecutively admitted hip fracture patients receiving either a DOAC or VKA with age- and gender-matched controls between January 1, 2010 and March 24, 2014 to determine how anticoagulation with a VKA or DOAC affects TTS.

TL;DR: AUB is frequent after initiation of anticoagulant therapy for acute symptomatic VTE patients of reproductive age and compared to VKAs, rivaroxaban was associated with prolonged menstrual bleeding and more medical interventions and adaptation of anti-cancer treatment.

TL;DR: Accuracy of VTE detection significantly improved with addition of treatment data to ICD-9 codes, and this approach should facilitate use of administrative data to assess the incidence, epidemiology, and outcomes of Vte.

TL;DR: Until laboratory assays are universally available to evaluate DOAC adherence, physicians should emphasize the importance of anticoagulation adherence at each patient encounter.

TL;DR: The VTE risk is increased in patients with natural anticoagulants deficiency, but additional studies are warranted to better assess the risk of VTE recurrence.

TL;DR: Stress-induced activation of the sympathoadrenal medullary system activates both the coagulation and fibrinolysis system resulting in net hypercoagulability, which protects an organism from excess bleeding should injury occur in fight-or-flight situations.

TL;DR: The aim of this study was to prospectively determine the incidence of thromboembolic events in a cohort of carriers of isolated LAC positivity and underline the importance of differentiating LAC carriers in terms of isolated positivity or positivity associated with the presence of antibodies to aCL and β2-glycoprotein I.

TL;DR: Investigation VTE risk can be stratified by cancer site, and pancreatic, brain, other digestive cancers, and lymphoma had significantly higher RRs than the grouped comparison cancers.

TL;DR: The results indicate that pobatinib inhibits platelet function, which may be the result of the effect of ponatinib on other organs or cell types, or disease-specific processes, such as BCR-ABL+cells undergoing apoptosis in response to chemotherapy, or drug-induced adverse effects on the integrity of the vascular endothelium in p onatinib-treated patients.

TL;DR: The group of MPN patients with JAK2 V617F allele burden higher than 20% may benefit the most from vigilant monitoring and appropriate prophylaxis against vascular events, and inclusion in new risk stratifications seems to be justified and requires controlled prospective trials.

TL;DR: Although treatment is administered strokes and subsequent TIAs are very common in individuals that suffered an initial event, research indicates that research needs to be done to better treat ischemic events to not only decrease the amount of recurring events but also decrease stroke mortality worldwide.

TL;DR: Emerging data suggest that microfluidic assays may also reveal consistent patterns of hemostatic or thrombotic pathology, and could aid in assessing and monitoring patient-specific effects of coagulation-modifying therapies.

TL;DR: Heterogeneous duration of anticoagulant treatment is observed for the secondary prevention of VTE in patients with VTE secondary to transient risk factors and cancer; fatal bleeding was more frequent than fatal recurrent PE in all subgroups.

TL;DR: In all cases the change of anticoagulation therapy was due to logistic problems with INR monitoring that interfered with the professional activities of the patients and/or unstable INR values resulting in time in the therapeutic range below 50%.

TL;DR: Tissue factor-activated viscoelastic testing (EXTEM) revealed individuals with warfarin-induced INR elevation accurately, while TEG - activated through the intrinsic pathway - still was of acceptable diagnostic value.

TL;DR: Anti-FXa-assay performed well upon apixaban concentrations in a normal exposure range, and still LC-MS/MS remains the "gold standard" method, covering also low concentrations.

TL;DR: Daily hospitalization costs of patients with an admitting/primary diagnosis of DVT or PE were high in the first days and became stable on the third day of the hospitalization, and it was suggested that any change in the LOS could significantly affectospitalization costs.

TL;DR: Rates of thrombotic and bleeding events were similar in patients with TT and patients with ticagrelor and warfarin, and the incidence of spontaneous major bleeding was similar between the groups.

TL;DR: A relationship between hypercoagulability detected by whole blood thromboelastometry and aggregometry and increased fat mass is shown and is correlated with inflammatory markers.

TL;DR: It is confirmed that normalisation of CAT results with a suitable external RP is useful in "real life" practice as it often permits an acceptable level of interlaboratory variability.

TL;DR: Direct oral factor Xa inhibitors are more effective to prevent venous thromboembolism after total hip or knee replacement and their anticoagulant effect was not necessarily compromised with a higher bleeding risk.

TL;DR: In this paper, the authors measured plasma histone H3 (H3) levels in the plasma of 43 sepsis patients who were admitted to the Intensive Care Unit and determined their correlation with disease severity, organ failure, mortality and coagulation-and tissue homeostasis parameters including LDH levels, thrombin potential (ETP), prothrombin levels, antithrombin level and platelet counts.

TL;DR: Non-physiological high shear stresses with short exposure time can induce shedding of platelet GPIbα and GPVI receptors, which may lead platelet dysfunction and influence the coagulation system.

TL;DR: The results of this pilot study indicate that plasma miRNAs profiling can provide novel biomarkers of unprovoked VTE.