Showing papers in "Transfusion in 2014"

TL;DR: There is considerable variation among the 218 clinical trials assessed here; variations include proposed mechanisms of action, optimal dosing strategy, and route of administration and attention must be given to the optimization of MSC culture.

TL;DR: Results show that fibrinogen concentrate is associated with a reduction or even total avoidance of allogeneic blood product transfusion, and represents an important option for the treatment of coagulopathic bleeding; further studies are needed to determine precise dosing strategies and thresholds for fibr inogen supplementation.

TL;DR: Postpartum hemorrhage remains one of the leading causes of maternal morbidity and mortality worldwide, although the lack of a precise definition precludes accurate data of the absolute prevalence of PPH.

TL;DR: The impact of clinical decision support at computerized physician order entry and education on red blood cell (RBC) transfusions and clinical patient outcomes at an institution is assessed.

TL;DR: Evaluated the prevalence of preoperative anemia in elective fast‐track THA and TKA and its association with risk of perioperative transfusion, prolonged length of hospital stay (LOS), and postoperative readmission.

TL;DR: These statements are intended to prompt non– transfusion medicine physicians to rethink their engrained culture of liberal transfusion practice and prompt patients to question why they are being prescribed blood.

TL;DR: Blood utilization at Stanford Hospital and Clinics after implementing real‐time clinical decision support (CDS) and best practice alerts (BPAs) into physician order entry (POE) for blood transfusions is analyzed.

TL;DR: Dietary studies show a relationship between the intake of iron enhancers and inhibitors and iron stores in the general population, but the impact of dietary factors on the iron stores of blood donors, whose iron status is affected by blood donations, is unclear.

TL;DR: In this article, a thromboelastometry (ROTEM)-guided coagulation management with Coagulation Factor Concentrates (CFCs) was evaluated in liver transplant patients.

TL;DR: Severely anemic patients for whom blood transfusion is not an option provide highly valuable information on risks of anemia and alternative management strategies.

TL;DR: More data are needed about seroprevalence, incidence, and viremia in blood donors for the assessment of risk of transfusion‐transmitted (TT)‐HEV infections.

TL;DR: This report summarizes the population and their previous nonimmune and immune transfusion complications and describes the risks and benefits of transfusions for thalassemia.

TL;DR: The objective was to identify risk factors and potential preventive measures by reviewing the literature on transfusion‐associated hyperkalemic cardiac arrest (TAHCA) in the pediatric population.

TL;DR: It is hypothesized that adding tranexamic acid (TXA) to a restrictive blood transfusion protocol would reduce the need for postoperative autologous blood retransfusion in primary knee and hip arthroplasty.

TL;DR: A meta‐analysis was performed to compare long‐ and short‐term outcomes of ELBW infants in trials of enhanced placental transfusion regimens.

TL;DR: The aim of this study was to understand the mechanisms responsible for the hemostatic potential of cryopreserved PLTs and the contribution of the reconstitution solution to this activity.

TL;DR: The implementation and impact of a patient blood management program (PBMP) in an Australian teaching hospital is described and the costs and benefits are described.

TL;DR: The Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III) is a 7‐year multicenter transfusion safety research initiative launched in 2011 by the National Heart, Lung, and Blood Institute.

TL;DR: In the Netherlands in 2013, the routine screening of 35,220 plasma donations for HEV RNA showed 20 donors to be viremic, which seems to contradict reports of declining HEV seroprevalence in the recent past.

TL;DR: Canadian Blood Services has been conducting quality monitoring of red blood cell (RBC) components since 2005, a period spanning the implementation of semiautomated component production.

TL;DR: This study compared transfusion reaction rates in InterSol PLTs (PLT additive solution [PAS] C] C) versus PPs.

TL;DR: The impact of InterSol platelet additive solution (PAS) apheresis platelets (APs) on the incidence of allergic transfusion reaction (ATR) and the posttransfusion platelet (PLT) increment is evaluated.

TL;DR: Fresh‐frozen plasma (FFP) is sometimes administered to nonbleeding preterm neonates who are judged to be at risk for bleeding because they have abnormal coagulation tests.

TL;DR: In this paper, the authors applied a murine model of RBC storage and transfusion to test the hypothesis that genetically distinct inbred strains of mice would demonstrate strain-specific differences in RBC recovery.

TL;DR: This study was conducted to investigate the effects of the first benchmark study and demonstrated relatively high transfusion rate and an abundance of nonindicated transfusions in elective surgeries.

TL;DR: The aim of this study was to assess the optimal isolation and cryopreservation procedures to facilitate WJ MSC banking.

TL;DR: The main objective of this study was to characterize the demographic features, clinical presentation, patient outcomes, and antibody profiles of TRALI patients reported to the Canadian Blood Service and to assess similarities and differences between adult and pediatric TRALi cases.

TL;DR: Patient blood management programs seek to optimize the utilization of blood components and the annual number of red blood cell (RBC) units transfused has decreased by 27% overall.

TL;DR: Dimethyl sulfoxide (DMSO) is essential for the preservation of liquid nitrogen–frozen stem cells, but is associated with toxicity in the transplant recipient.

TL;DR: This study characterized the dynamics of WNV viremia in blood compartments in a longitudinal cohort of 54 WNV‐infected blood donors.