Showing papers in "Trends in Biochemical Sciences in 1977"

TL;DR: Fortgeführt von A.Knoop, K.Thomas und K. Weitzel unter Mitwirkung von K.G.Thomas • Herausgegeben von a.L.

TL;DR: Information encoded in specific sugar residues o f membrane glycoproteins exerts a profound effect on cellular reactivity.

TL;DR: It appears that this highly reactive species of oxygen can be produced in several biochemical systems without the use of light and its reactions may account for some types of cell damage.

TL;DR: A mixed function (drug) oxidase located on the endoplasmic reticulum near the sites of protein synthesis can provide oxidizing equivalents ideal for protein disulfide bond formation.

TL;DR: Predicted secondary structures of proteins (α-helix, β-pleated sheet and β-turns) give insight into the understanding of protein folding and biological activity.

TL;DR: It is shown that pH and ionic strength are tightly interdependent in cytochrome oxidase activity at the level of inner membranes of the mitochondrion, as a direct consequence of the polyanionic environment of this enzyme.

TL;DR: As well as being catalysts of several different types of reactions, the glutathione S -transferases also act as storage proteins and undergo covalent linkage with highly reactive electrophilic compounds as discussed by the authors.

TL;DR: Several lines of evidence indicate that the site of this reversible oxygen interaction with photosynthesis is ribulose 1,5-bisphosphate carboxylase, which is related to net photosynthesis in many major crop species.

TL;DR: Mitochondria contain a separate genetic system, specfying a small but essential part of the RNAs and proteins found in mitochondria, which is now largely known, but the biological advantage of having this extra genetic system in mitochondrial DNA is still unclear.

TL;DR: New insights into the physiological role of polyamines have been obtained from studies of polyamine-deficient mutants of Escherichia coli, leading to the conclusion that these organic cations participate directly in protein synthesis.

TL;DR: Dietary trends that show increased consumption of more highly processed foods may be leading to deficiencies of GTF and chromium in man, which is an essential dietary agent that potentiates the action of insulin and thereby functions in regulating carbohydrate metabolism.

TL;DR: In some eukaryotic multienzyme complexes, different enzymes are linked covalently, probably as discrete domains of a single polypeptide chain, and will stabilize the complexes more effectively than non-covalent associations.

TL;DR: Biochemical changes coincident with the physiological response of Acinetobacter sp.

TL;DR: In certain amino acid decarboxylases and other enzymes, covalently bound pyruvate or related compounds supply an alternative to pyridoxal 5′-phosphate for providing a catalytically essential ‘carbonyl' group at the catalytic center.

TL;DR: Ingestion of particulate matter by phagocytic cells initiates a very rapid production of microbicidal oxygen metabolites in these cells, which constitutes a powerful defense against invading microorganisms.

TL;DR: RSV carries a gene, UC, which is superfluous for viral replication but which is essential for the maintenance of the transformed physiology of fibroblasts, and which maps in the region deleted from the td mutants.

TL;DR: The National Institutes of Health recently came under criticism from the General Accounting Office, the investigatory arm of Congress, for not making its own scientists put their research proposals through the same peer review system by which the NIH judges the proposals of others.

TL;DR: A description is given of the mutual interactions between lipid and protein molecules in a membrane.

TL;DR: The mechanism of catabolite repression involves a sugar-dependent regulation of adenylate cyclase through phosphorylation-dephosphorylation via phosphorylated-depHosphorylated interaction with the sugar transport system.

TL;DR: The synthesis of enzymes capable of providing enteric bacteria with ammonia and glutamate is activated by glutamine synthetase, which regulates its own synthesis in response to the intracellular levels of 2-ketoglutarate and glutamine.

TL;DR: There is growing evidence that energy-linked protein conformational changes have a key role in many biological energy transductions and one of these is in the use of energy to make ATP by mitochondria and chloroplasts.

TL;DR: Carnitine, which is an acyl carrier within the mitochondrial membrane, is synthesized from e- N -trimethyllysine in rat liver by enzymatic methylation of protein-lysine residues using S -adenosyl-l-methionine and subsequent degradation by hepatocyte lysosomes.