Showing papers in "Trends in Parasitology in 2018"
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TL;DR: Systematic studies of C. parvum and C. hominis populations are likely leading to improved understanding of population structures underlying various transmission patterns and intensities of Cryptosporidium.
317 citations
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TL;DR: In the United States, the blacklegged tick, Ixodes scapularis, is a vector of seven human pathogens, including those causing Lyme disease, anaplasmosis, babesiosis, Borrelia miyamotoi disease, Powassan virus disease, and ehrlichia muris eauclarensis.
206 citations
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TL;DR: Investments to strengthen surveillance, build robust early-warning systems, improve predictive models, and coordinate public health responses may help to prevent, detect, and respond to new infectious disease epidemics.
148 citations
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Carlos III Health Institute1, Institute of Tropical Medicine Antwerp2, Food and Agriculture Organization3, University of Basel4, Swiss Tropical and Public Health Institute5, Institut de recherche pour le développement6, Instituto de Medicina Molecular7, World Health Organization8, University of Glasgow9, Makerere University10, University of Liverpool11, Foundation for Innovative New Diagnostics12, Institute for Systems Biology13, Pasteur Institute14, University of Dschang15
TL;DR: It is argued that a better understanding of the contribution of human and putative animal reservoirs to gambiense-HAT epidemiology is mandatory to inform elimination strategies.
126 citations
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TL;DR: This review covers recent advances in the study of insect trypanosomatids, highlighting their diversity as well as genetic, morphological and biochemical complexity, which, until recently, was underappreciated.
120 citations
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TL;DR: In this paper, the authors collate existing evidence that these parasites are, at minimum, indicators of intestinal microbiota structure and function and conclude that they are active manipulators of gut microbiota structure.
113 citations
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TL;DR: How mathematical models give insight into the dynamics of the spread of Wolbachia, the potential impact of Wol Bachia on dengue transmission, and the remaining challenges in evaluation and development are reviewed.
86 citations
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TL;DR: This link between melarsoprol and AQP2 illustrates how a drug transporter can improve drug selectivity but, at the same time, highlights the risk of resistance when the drug uptake mechanism is dispensable for parasite viability and virulence.
81 citations
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TL;DR: How virus-mosquito interactions are critical for these viruses to become global pathogens at molecular, physiological, evolutionary, and epidemiological scales is summarized.
79 citations
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TL;DR: In this paper, the authors present ideas for modernizing and scaling up snail control, including spatiotemporal targeting, environmental diagnostics, better molluscicides, new technologies (e.g., gene drive), and "outside the box" strategies such as natural enemies, traps, and repellants.
76 citations
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TL;DR: The most important milestones in avian Plasmodium research are reviewed and it is explained why this is a unique animal model to understand the ecology and evolution of malaria.
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TL;DR: Views on the parasite ligands that may play a role in Duffy-negative P. vivax infections are reported and clues gained from studying P.Vivax infection of reticulocytes are presented, which may provide possible avenues for establishing P.vivax culture in vitro.
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TL;DR: Recent Tv research has uncovered new players that contribute to multifactorial mechanisms of host-parasite adherence and killing, and has examined the relationship between Tv and vaginal bacteria.
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TL;DR: The views of 25 international mosquito experts about the current state of MBD control are summarized and the issues that must be addressed in order to tackle emerging threats on the horizon are highlighted.
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TL;DR: The need for further integrated pharmaco-parasitological knowledge is emphasized to extend the lifespan of both traditional and novel anthelmintic compounds, and to progress in the identification of complementary/alternative measures of parasite control in livestock animals.
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TL;DR: Recent advances in HSC biology and the role of HSCs in hepatic schistosomiasis are discussed, and a better understanding of these interactions could lead to improved resolution of fibrotic liver disease, including that associated with schistsomiasis.
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TL;DR: It is critical to monitor the long-term stability of Wolbachia in host populations, and also the ability of this bacterium to continually inhibit virus transmission, should political support weaken when these vectors are successfully controlled.
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TL;DR: Ten important research events that were pivotal in resistance research are examined, including the discovery, description, and diagnosis of parasite resistance, as well as important physiological and genetic findings, and the development of online tools to help manage resistance.
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TL;DR: The rationale for the development of TBIs is outlined, with a focus on transmission- blocking drugs and (parasite-derived) transmission-blocking vaccines, and the current status of each intervention classes is described and summarised.
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TL;DR: This review focuses on the innate immune pathways that regulate immunity to helminth parasites and describes how better understanding of these pathways may lead to the development of new therapeutic strategies.
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TL;DR: A conceptual framework of potential interactions, nested within the parasite spillback hypothesis, is presented, and two new concepts, disease facilitation and suppressive spillover, are introduced, which may aide in the understanding of ecological drivers of invasion and parasite ecology and can be used to improve mitigation strategies.
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TL;DR: It is the opinion that, although GMM-based control strategies can be considered a promising control tool, more studies are needed to assess their true effectiveness, risks, and benefits.
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TL;DR: The limitations of current chemotherapeutic approaches to manage HAT are examined, the constraints to new drug development exploring drug failures and new drugs on the horizon are considered, and the epidemiological, political, social, and economic factors influencing drug development are considered.
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TL;DR: The rationale for soil-transmitted helminthiasis- and schistosomiasis-specific WASH considerations, and a traffic-light figure, are presented here to indicate where current international definitions may, or may not, suffice.
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TL;DR: The issue of the species concept in tick taxonomy is addressed and the adoption of an integrative species concept is discussed, in light of recent advances in understanding of the genetics, morphology, and biology of ticks.
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TL;DR: An overview of the burden of STH infections, the evolution of PC along with its success and challenges, recent estimates of the efficacy of recommended drugs, and alternative treatment options are presented.
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TL;DR: An overview of the health and economic burden estimates of dengue in Vietnam is provided to provide an overview and important research gaps for future studies are highlighted.
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TL;DR: This review summarizes and discusses the recent advances in the knowledge of MROs from parasitic protists, particularly the themes such as metabolic functions, contribution to parasitism, dynamics, protein targeting, and novel lineage- specific proteins, with emphasis on the diversity among these organelles.
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TL;DR: A review of recent advances in deciphering the mitotic structures and cell cycle regulatory factors required by Apicomplexa parasites to replicate shows that the highly unconventional cell cycles of these parasites is a blending of many ancient and borrowed elements.
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TL;DR: New opportunities for host-targeted therapeutics for malaria and the potential to harness drug polypharmacology to simultaneously target multiple host pathways using a single drug intervention are discussed.