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Showing papers in "Trends in Parasitology in 2018"


Journal ArticleDOI
TL;DR: Systematic studies of C. parvum and C. hominis populations are likely leading to improved understanding of population structures underlying various transmission patterns and intensities of Cryptosporidium.

317 citations


Journal ArticleDOI
TL;DR: In the United States, the blacklegged tick, Ixodes scapularis, is a vector of seven human pathogens, including those causing Lyme disease, anaplasmosis, babesiosis, Borrelia miyamotoi disease, Powassan virus disease, and ehrlichia muris eauclarensis.

206 citations


Journal ArticleDOI
TL;DR: Investments to strengthen surveillance, build robust early-warning systems, improve predictive models, and coordinate public health responses may help to prevent, detect, and respond to new infectious disease epidemics.

148 citations



Journal ArticleDOI
TL;DR: This review covers recent advances in the study of insect trypanosomatids, highlighting their diversity as well as genetic, morphological and biochemical complexity, which, until recently, was underappreciated.

120 citations


Journal ArticleDOI
TL;DR: In this paper, the authors collate existing evidence that these parasites are, at minimum, indicators of intestinal microbiota structure and function and conclude that they are active manipulators of gut microbiota structure.

113 citations


Journal ArticleDOI
TL;DR: How mathematical models give insight into the dynamics of the spread of Wolbachia, the potential impact of Wol Bachia on dengue transmission, and the remaining challenges in evaluation and development are reviewed.

86 citations


Journal ArticleDOI
TL;DR: This link between melarsoprol and AQP2 illustrates how a drug transporter can improve drug selectivity but, at the same time, highlights the risk of resistance when the drug uptake mechanism is dispensable for parasite viability and virulence.

81 citations


Journal ArticleDOI
TL;DR: How virus-mosquito interactions are critical for these viruses to become global pathogens at molecular, physiological, evolutionary, and epidemiological scales is summarized.

79 citations


Journal ArticleDOI
TL;DR: In this paper, the authors present ideas for modernizing and scaling up snail control, including spatiotemporal targeting, environmental diagnostics, better molluscicides, new technologies (e.g., gene drive), and "outside the box" strategies such as natural enemies, traps, and repellants.

76 citations


Journal ArticleDOI
TL;DR: The most important milestones in avian Plasmodium research are reviewed and it is explained why this is a unique animal model to understand the ecology and evolution of malaria.

Journal ArticleDOI
TL;DR: Views on the parasite ligands that may play a role in Duffy-negative P. vivax infections are reported and clues gained from studying P.Vivax infection of reticulocytes are presented, which may provide possible avenues for establishing P.vivax culture in vitro.

Journal ArticleDOI
TL;DR: Recent Tv research has uncovered new players that contribute to multifactorial mechanisms of host-parasite adherence and killing, and has examined the relationship between Tv and vaginal bacteria.

Journal ArticleDOI
TL;DR: The views of 25 international mosquito experts about the current state of MBD control are summarized and the issues that must be addressed in order to tackle emerging threats on the horizon are highlighted.

Journal ArticleDOI
TL;DR: The need for further integrated pharmaco-parasitological knowledge is emphasized to extend the lifespan of both traditional and novel anthelmintic compounds, and to progress in the identification of complementary/alternative measures of parasite control in livestock animals.

Journal ArticleDOI
TL;DR: Recent advances in HSC biology and the role of HSCs in hepatic schistosomiasis are discussed, and a better understanding of these interactions could lead to improved resolution of fibrotic liver disease, including that associated with schistsomiasis.

Journal ArticleDOI
TL;DR: It is critical to monitor the long-term stability of Wolbachia in host populations, and also the ability of this bacterium to continually inhibit virus transmission, should political support weaken when these vectors are successfully controlled.

Journal ArticleDOI
TL;DR: Ten important research events that were pivotal in resistance research are examined, including the discovery, description, and diagnosis of parasite resistance, as well as important physiological and genetic findings, and the development of online tools to help manage resistance.

Journal ArticleDOI
TL;DR: The rationale for the development of TBIs is outlined, with a focus on transmission- blocking drugs and (parasite-derived) transmission-blocking vaccines, and the current status of each intervention classes is described and summarised.

Journal ArticleDOI
TL;DR: This review focuses on the innate immune pathways that regulate immunity to helminth parasites and describes how better understanding of these pathways may lead to the development of new therapeutic strategies.

Journal ArticleDOI
TL;DR: A conceptual framework of potential interactions, nested within the parasite spillback hypothesis, is presented, and two new concepts, disease facilitation and suppressive spillover, are introduced, which may aide in the understanding of ecological drivers of invasion and parasite ecology and can be used to improve mitigation strategies.

Journal ArticleDOI
TL;DR: It is the opinion that, although GMM-based control strategies can be considered a promising control tool, more studies are needed to assess their true effectiveness, risks, and benefits.

Journal ArticleDOI
TL;DR: The limitations of current chemotherapeutic approaches to manage HAT are examined, the constraints to new drug development exploring drug failures and new drugs on the horizon are considered, and the epidemiological, political, social, and economic factors influencing drug development are considered.

Journal ArticleDOI
TL;DR: The rationale for soil-transmitted helminthiasis- and schistosomiasis-specific WASH considerations, and a traffic-light figure, are presented here to indicate where current international definitions may, or may not, suffice.

Journal ArticleDOI
TL;DR: The issue of the species concept in tick taxonomy is addressed and the adoption of an integrative species concept is discussed, in light of recent advances in understanding of the genetics, morphology, and biology of ticks.

Journal ArticleDOI
TL;DR: An overview of the burden of STH infections, the evolution of PC along with its success and challenges, recent estimates of the efficacy of recommended drugs, and alternative treatment options are presented.

Journal ArticleDOI
TL;DR: An overview of the health and economic burden estimates of dengue in Vietnam is provided to provide an overview and important research gaps for future studies are highlighted.

Journal ArticleDOI
TL;DR: This review summarizes and discusses the recent advances in the knowledge of MROs from parasitic protists, particularly the themes such as metabolic functions, contribution to parasitism, dynamics, protein targeting, and novel lineage- specific proteins, with emphasis on the diversity among these organelles.

Journal ArticleDOI
TL;DR: A review of recent advances in deciphering the mitotic structures and cell cycle regulatory factors required by Apicomplexa parasites to replicate shows that the highly unconventional cell cycles of these parasites is a blending of many ancient and borrowed elements.

Journal ArticleDOI
TL;DR: New opportunities for host-targeted therapeutics for malaria and the potential to harness drug polypharmacology to simultaneously target multiple host pathways using a single drug intervention are discussed.