Journal•ISSN: 0165-6147
Trends in Pharmacological Sciences
Elsevier BV
About: Trends in Pharmacological Sciences is an academic journal published by Elsevier BV. The journal publishes majorly in the area(s): Receptor & G protein-coupled receptor. It has an ISSN identifier of 0165-6147. Over the lifetime, 5481 publications have been published receiving 419091 citations. The journal is also known as: Trends in pharmacological sciences including toxicological sciences.
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TL;DR: The recent discovery of a pathogenic mutation in the beta-amyloid precursor protein (APP) gene on chromosome 21 suggests that APP Mismetabolism and beta-amide deposition are the primary events in the disease process.
2,279 citations
TL;DR: The results suggest that brain reward systems have a multidetermined neuropharmacological basis that may involve some common neuroanatomical elements.
2,110 citations
TL;DR: In vivo and in vitro studies of the cytotoxicity of amino acids are reviewed and the contribution of such toxicity to acute and chronic neurodegenerative disorders is summarized.
1,873 citations
1,671 citations
TL;DR: This review focuses on recent findings regarding some of the most widely employed animal models used currently to predict antidepressant potential, and emphasis is placed on recent modifications to such paradigms that have increased their utility and reliability.
1,518 citations