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Showing papers in "Virology in 1991"


Journal ArticleDOI
01 Nov 1991-Virology
TL;DR: Findings on the genetic organization and expression strategy of HEV suggest that it is the prototype human pathogen for a new class of RNA virus or perhaps a separate genus within the Caliciviridae family.

1,016 citations


Journal ArticleDOI
01 Sep 1991-Virology
TL;DR: Virus infection and viral gene expression emerge as necessary but obviously not sufficient factors for cancer induction, and “endogenous” modifications seem to be most important in the pathogenesis of premalignant lesions and tumor progression.

839 citations


Journal ArticleDOI
01 Feb 1991-Virology
TL;DR: It is suggested that the mature NS1/E2 polypeptide starts about amino acid 380 and that the NS1-E2 domain may correspond to a second envelope glycoprotein as in the case of the pestivirus.

651 citations


Journal ArticleDOI
01 Jul 1991-Virology
TL;DR: The relative sensitivity of a virus to the inhibitory action of IFN is governed by the qualitative nature and quantitative amount of the individual IFN-regulated cell proteins that may collectively contribute to the inhibition of virus replication.

603 citations


Journal ArticleDOI
01 Nov 1991-Virology
TL;DR: The production of HPV-like particles using recombinant vaccinia virus should be useful for biochemical studies and could provide a safe source of material for the development of a vaccine.

573 citations


Journal ArticleDOI
01 Nov 1991-Virology
TL;DR: Effective whitefly-mediated transmission of the virus from agroinoculated plants to test plants demonstrated that the cloned molecule carries all the information needed for virus replication, systemic infection, and transfer by whiteflies.

486 citations


Journal ArticleDOI
01 Jun 1991-Virology
TL;DR: Several amino acid residues in fusion peptides and receptor-binding sites were shown to be conserved among the 13 HA serotypes, and results show that the amino acid residue at position 226 is not necessarily a determinant of receptor specificity for all serotypes.

467 citations


Journal ArticleDOI
01 Feb 1991-Virology
TL;DR: The evidence presented shows that the M2 protein of influenza A viruses exists in infected cells as a homotetramer composed of two disulfide-linked dimers held together by noncovalent interactions, providing a structural basis for the hypothesis that M2 has a proton translocation function capable of regulating the pH of vesicles of the trans-Golgi network.

462 citations


Journal ArticleDOI
01 Dec 1991-Virology
TL;DR: The results suggest that the genotypes of some viruses in vitro are not stable and that selection for growth can cause the fairly rapid appearance of variants with increased growth potential.

398 citations


Journal ArticleDOI
01 Dec 1991-Virology
TL;DR: Observations indicate that the cytopathic effect of HIV infection is associated with apoptosis and the detection of histones and oligonucleosomal DNA fragments in the nucleoplasm can be used as a convenient marker for chromatin fragmentation during this process.

361 citations


Journal ArticleDOI
01 Feb 1991-Virology
TL;DR: This study completes the sequence of the MHV genome, which is 31 kb long, and constitutes the largest viral RNA known.

Journal ArticleDOI
01 Jul 1991-Virology
TL;DR: Data suggest that disulfide bond formation, although not essential for oligomeric assembly, stabilizes the M2 tetramer from disruption by detergent solubilization.

Journal ArticleDOI
01 Apr 1991-Virology
TL;DR: The sequence of Epstein-Barr virus and B lymphocyte changes in the 3 days following acute infection was analyzed and compatible with a key role for EBNA-2 (orEBNA-LP) in regulating virus and cell gene expression was compatible.

Journal ArticleDOI
01 Oct 1991-Virology
TL;DR: Restriction enzyme analysis revealed that HHV-6 isolates from roseola, bone marrow transplant, leukopenia, and an HIV-1-positive AIDS patient from Zaire (Z-29) were closely related but distinct from GS type HHVs, suggesting that, like herpes simplex virus types 1 and 2, the 15 isolates analyzed can be divided into group A and group B.

Journal ArticleDOI
01 Oct 1991-Virology
TL;DR: The RNA genome of the rabbit hemorrhagic disease virus (RHDV) was molecularly cloned in this article, and the 5′ terminal sequence of the genomic RNA was determined after PCR amplification of a G-tailed first strand cDNA template.

Journal ArticleDOI
01 Apr 1991-Virology
TL;DR: CD4 expression on various human, rhesus, and African green monkey cell lines confers differential susceptibilities for HIV-1, HIV-2, and simian immunodeficiency (SIV) strains, and studies of cell fusion and of infection by vesicular stomatitis virus pseudotypes showed that the differential cell tropisms of HIV- said to be determined at the cell surface.

Journal ArticleDOI
01 Sep 1991-Virology
TL;DR: The term "viroceptor" is proposed to describe viral-encoded homologs of cellular lymphokine receptors whose function is to intercept the activity of the cognate lymphokines in order to short circuit the host immune response to the viral infection.


Journal ArticleDOI
01 Nov 1991-Virology
TL;DR: Glomerulopathy in these transgenic mice and HIV-associated nephropathy in man have similar features and the presence of HIV-related protein in the glomeruli of affected animals was revealed.

Journal ArticleDOI
01 Jul 1991-Virology
TL;DR: The results suggest that both the 3a protein and the coat protein are involved in virus transport, and that viral assembly is associated with long-distance movement of CMV.

Journal ArticleDOI
01 Dec 1991-Virology
TL;DR: A model that accounts for all proteolytic processing events in the potyviral polyprotein is presented and suggests that the 35-kDa protein functions as a proteinase to cleave at its C-terminus.

Journal ArticleDOI
01 Feb 1991-Virology
TL;DR: Extension of these studies to include the remaining 14 unassigned serotypes indicated that 13 serotypes belong to the major group since their infection of HeLa cells is completely blocked by a monoclonal antibody that recognizes themajor group receptor.

Journal ArticleDOI
01 Jun 1991-Virology
TL;DR: PVX/PVY synergism involves an alteration in the normal regulation of the relative levels of PVX (+) and (-) strand RNAs during viral replication, which is suggested to be due to an increased rate of synthesis.


Journal ArticleDOI
01 Sep 1991-Virology
TL;DR: It was concluded that the capsid proteins of all rod-shaped viruses, on the one hand, and filamentous viruses,on the other hand, evolved from common ancestors.

Journal ArticleDOI
01 Jan 1991-Virology
TL;DR: Four recombinant vaccinia viruses engineered for expression of different portions of the Japanese encephalitis virus (JEV) open reading frame provided protection against lethal challenge with JEV and were correlated with the production of high titers of neutralizing and hemagglutination-inhibiting antibodies.

Journal ArticleDOI
01 Jul 1991-Virology
TL;DR: Analysis of recombinant viruses mapped both CPV- and FPV-specific antigenic epitopes, the pH dependence of HA, and sequences affecting canine host range of the viruses within the VP-1 and VP-2 structural protein genes.

Journal ArticleDOI
01 Feb 1991-Virology
TL;DR: In one child, the V3 sequence determined directly from brain DNA was very distant from the consensus brain clone sequence and from the spleen sequences, suggesting a diverging quasispecies distribution.

Journal ArticleDOI
01 Oct 1991-Virology
TL;DR: It is shown that treatment of these membranes with subtilisin releases the carboxy-terminal segment of the NS 3 protein as a soluble protein of about 50 kDa apparent molecular weight, which is called the p50-S protein and a possible function of this protein segment during RNA synthesis is discussed.

Journal ArticleDOI
01 Feb 1991-Virology
TL;DR: The sequences and coding strategies of the S RNAs of two viruses, Toscana (TOS) and the M12 derivative of Rift Valley fever ZH-548 (RVF, Phlebovirus genus, Bunyaviridae) have been determined from cDNA clones and compared to the previously published sequences of Punta Toro (PT), Sandfly fever Sicilian (SFS), and Uukuniemi (UUK) viruses.