Showing papers in "Virology in 2004"

TL;DR: The higher-order PV taxonomy is described following the general criteria established by the International Committee on the Taxonomy of Viruses (ICTV), reviews the literature of the lower order taxa, lists all known "PV types", and interprets their phylogenetic relationship.

TL;DR: The data indicate that the amino acid at position 627 of the PB2 protein determines the efficiency of viral replication in mouse (not avian) cells, but not tropism among cells in different mouse organs.

TL;DR: The results indicate that TLR3 is not universally required for the generation of effective antiviral responses because the absence ofTLR3 does not alter either viral pathogenesis or impair host's generation of adaptive antiviral response to these viruses.

TL;DR: The SEAP pseudovirus-based neutralization assay should be a practical method for quantifying potentially protective antibody responses in HPV natural history and prophylactic vaccine studies.

TL;DR: RKSHV.219 efficiently established latent infections from which the virus could be reactivated to productive lytic replication and the production of infectious virus, and demonstrated strong synergy between KSHV/RTA and butyrate for the activation of KSHv lytic replicate and theproduction of infectious viruses.

TL;DR: An interspecies HEV transmission between boar and deer in their wild life, and that both animals might serve as an infection source for human beings as suggested previously, are suggested.

TL;DR: Detergent-resistant membrane (DRM) fractions containing NS proteins and viral RNA were capable ofHCV RNA synthesis using the endogenous HCV RNA template, and suggested that the HCV RCs are protected within lipid rafts.

TL;DR: The results indicate that AAV10 and AAV11 capsid proteins are likely to determine their host ranges and tissue tropism that are different from AAV2s, suggesting that cynomolgus AAVs could provide a broader choice of pseudotype AAV vectors for gene therapy.

TL;DR: Affinity-purified polyclonal antibodies recognizing the N-terminal 19 residues of SARS-CoV E protein were used to establish the specificity of channel formation by inhibiting the ion currents generated in the presence of the E protein peptides.

TL;DR: The analysis shows that DNA 1 components are associated with the majority of begomovirus-DNA beta complexes, being absent from only two of the complexes examined, both of which have their origins in Far East Asia.

TL;DR: Surprisingly, RNA was also found to be essential for formation of the nucleocapsid--APOBEC3G complex in vitro, thus raising the possibility that RNA may form a bridge between these two proteins.

TL;DR: It is demonstrated that the satellite encodes at least one protein that plays a major role in symptom development and is essential for disease progression in ageratum, the natural host of the AYVD complex.

TL;DR: The structures of H3, H5 and H9 subtype haemagglutinins were compared to deduced a structural basis for including all 15 influenza subtypes in four clades, and the division of the clades into two groups of two was confirmed.

TL;DR: The lack of apparent clinical illness in all three species, variability from animal to animal in level of viral replication, and rapid clearance of virus and pneumonitis in AGMs must be taken into account by investigators considering the use of these species in efficacy and challenge studies.

TL;DR: Results extend the previous findings and strongly suggest that various amphibian and piscine AMPs may play important roles in protecting fish and amphibians from pathogenic viruses.

TL;DR: Molecular epidemiology revealed that Swiss B1 strains differed no more from French, Brazilian or US strains than from each other, suggesting virus propagation through international livestock trade, thus indicating regularly occurring sheep-to-goat transmission.

TL;DR: Examination of cytokine secretion showed that KSHV infection significantly induces hIL-6 while strongly inhibiting secretion of IL-8, a gene product that is decreased by differentiation of blood to lymphatic endothelial cells.

TL;DR: It is suggested that H2N2 viruses continued to circulate after 1968 and that establishment of H3N2 virus in humans was associated with multiple reassortment events that contributed to their genetic diversity.

TL;DR: A better understanding of the molecular mechanisms underlying the process of codon optimization is provided and novel tools to study the biological functions of the Vpu and Vif proteins independently of other viral proteins are introduced.

TL;DR: Results indicate that neutralizing antibodies to these ASFV proteins are not sufficient for antibody-mediated protection.

TL;DR: Data indicating that adenovirus (Ad) serotype 3 utilizes CD80 and CD86 as cellular attachment receptors suggests a mechanism whereby viral exploitation of these proteins as receptors may achieve both goals of cellular entry and evading the immune system.

TL;DR: The effects of IFNs on the replication of two strains of severe acute respiratory syndrome-associated coronavirus are investigated and suggest that combination IFN treatment warrants further investigation as a treatment for SARS.

TL;DR: It is shown that most isolates of influenza A induce filamentous changes in infected cells in contrast to A/WSN/33 and A/PR8/34 strains which have undergone extensive laboratory passage and are mouse-adapted, and suggests that an interaction among these regions of M1 may occur during assembly.

TL;DR: The results indicate that HIV-1 Nef contributes to neuropathogenesis by directly causing astrocyte death together with indirect neuronal death through the cytotoxic actions of IP-10 on neurons.

TL;DR: It is concluded that chimeric CP7_E2alf may not only serve as a tool for a better understanding of Pestivirus attachment, entry, and assembly, but also represents an innocuous and efficacious modified live CSFV "marker vaccine".

TL;DR: DV RTPase seems to belong to a new class of Mg2+-dependent RTPases, which use the active center of the helicase/NTPase catalytic core in conjunction with elements in the C-terminal domain.

TL;DR: It is suggested that dimers of pentamers are the nucleus for L1 assembly into capsid-like structures, with rapid sequential addition of single pentamer to the growing shell, in contrast with the "five-around-one" assembly nucleus previously proposed for polyomaviruses.

TL;DR: Comparisons of SV40, JCV, and BKV will be compared based on what is known about their molecular biology from experiments performed in vitro, in cell culture and in laboratory animals to discuss the association of these viruses with clinical tumors.

TL;DR: Down-regulation of DDX1 resulted in an alternative splicing pattern of Rev-responsive element (RRE)-containing mRNA, and attenuation of Gag p24 antigen production from HLfb rev- cells rescued by exogenous Rev, which indicates thatDDX1 is a critical cellular co-factor for Rev function, which maintains the proper subcellular distribution of this lentiviral regulatory protein.

TL;DR: It is shown that PB2 contains two regions that bind NP and also identify a novel PB1 binding site, providing evidence for functionally significant and potentially regulatory interactions between PB2 and NP.