Book ChapterDOI
1,2,4-Triazolo[1,5-a]pyrimidines
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The formation of 1,2,4-triazolo [1,5-a] pyrimidines (TPs) was first reported by Biilow and Haas.Abstract:
Publisher Summary The formation of 1,2,4-triazolo [1,5-a] pyrimidines (TPs) was first reported by Biilow and Haas Over the next 50 years, only a few papers and patents on TPs were published, which were included in Mosby's comprehensive monograph on “Heterocyclic Systems with Bridgehead Nitrogen Atoms” Most syntheses of TPs start either from a 1,2,4-triazole derivative or from a pyrimidine residue and need annulation of a second heterocyclic ring Preferably 5-amino-1,2,4-triazoles (AT) and 2-hydrazinopyrimidines (HP) are used as starting synthons In the synthesis of TPs from HPs, intermediates are believed to exist and have been isolated in many cases These products and other acylated HPs may serve as convenient starting materials for cyclization reactions Acylated HPs are also prepared from 2-alkylthiopyrimidines and acylhydrazines and, further, cyclized in situ to triazolopyrimidines Many TPs have been tested as potential growth inhibitors of microorganisms, because they are isomeric to purines and in some cases can be converted to nucleoside analogsread more
Citations
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Journal ArticleDOI
Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis
TL;DR: In this paper, the authors summarized the results reported mainly within the last 10 years, and it is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis.
Journal ArticleDOI
Metal complexes of [1,2,4]triazolo-[1,5-a]pyrimidine derivatives
TL;DR: In this paper, the coordination chemistry of 1,2,4-triazolo-[1,5-a]-pyrimidine derivatives is reviewed. The revision is mainly focused in the structural features of the compounds, obtained from single crystal X-ray diffraction.
Journal ArticleDOI
An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles
TL;DR: In this paper, a catalyst-free highly efficient synthesis of 3(5)-amino-5(3)-(het)aryl-1,2,4-triazoles in aqueous medium was performed using conventional heating and microwave irradiation.
Book ChapterDOI
Recent Progress in 1,2,4-Triazolo[1,5-a]pyrimidine Chemistry
TL;DR: In this paper, the molecular dimensions, molecular spectra, thermodynamic properties, tautomerism, and betain and mesoionic structures of 1,2,4-triazolo[1,5-a]pyrimidines are discussed.
Journal ArticleDOI
Molecular structure and antitumor activity of platinum(II) complexes containing purine analogs
TL;DR: In this paper, the molecular and antitumor properties of this class of compounds were reviewed and a large amount of available spectroscopic and crystollographic data allows possible elucidation of geometrical parameters, such as bond lengths and angles, which may have an impact on the behavior of platinum(II) complexes against tumor cells.
References
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Journal ArticleDOI
Propotropic tautomerism of heteroaromatic compounds
TL;DR: In this article, a review dealing mainly with the prototropic side chain tautomerism of heteroaromatic compounds is presented, with particular reference made to molecular orbital calculations of equilibrium constants.
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The mechanisms of heterocyclic ring closures
Journal ArticleDOI
Die Dimroth-Umlagerung — Platzwechsel zwischen Ring- und Seitenkettenatomen von Heteroaromaten oder ihren Dihydrostufen unter intermediärer Ringöffnung
Journal ArticleDOI
New herbicidal derivatives of 1,2,4-triazolo [1,5-a] pyrimidine
William A. Kleschick,Mark J. Costales,Joseph E. Dunbar,Richard W. Meikle,William T. Monte,Norman R. Pearson,Sigrid W. Snider,Anna P. Vinogradoff +7 more
TL;DR: Two new structural classes of herbicide have been discovered which are based on the 1,2,4-triazolo[1,5-a]pyrimidine ring system as mentioned in this paper.
Journal ArticleDOI
On triazoles XI . structure elucidation of isomeric 1,2,4-triazolopyrimidinones
TL;DR: In this article, the structure of Isomeric 3-6 type triazolo-pyrimidinones and their N-methylated and N-benzylat-ed derivatives was elucidated.