What contributions have the authors mentioned in the paper "Sm and in dtpa derivatives with high hepatic specificity: in vivo and in vitro studies" ?

Two DTPA derivatives, a mono-amide derivative containing an iodinated synthon, DTPA-IOPsp ( L ) and the ligand DTPA ( BOM ) 1 3 153 31 111 31 ( BOM5benzyloxymethyl ) ( L ), radiolabelled with Sm and In, were studied as potential hepatospecific gamma scintigraphic 2 agents. In vivo studies with Wistar rats show that the main excretory pathway for all the chelates studied is the hepatobiliary system. The La 31 1 and In chelates of L and L show some structural and dynamic differences in aqueous solution, as studied by H NMR spectroscopy.

(Open Access) 153Sm3+ and 111In3+ DTPA derivatives with high hepatic specificity: in vivo and in vitro studies (2002) | M. I. M. Prata

Journal ArticleDOI

First in vivo MRI assessment of a self‐assembled metallostar compound endowed with a remarkable high field relaxivity

João Bruno Livramento, +11 more

- 01 Jan 2006 -

Contrast Media & Molecular Imaging

TL;DR: These studies have confirmed that the approximately four times higher relaxivity measured in vitro for the metallostar is retained under in vivo conditions.

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Journal ArticleDOI

Silencing of Phosphonate-Gadolinium Magnetic Resonance Imaging Contrast by Hydroxyapatite Binding

F. Caseiro Alves, +14 more

- 01 Dec 2003 -

Investigative Radiology

TL;DR: In vitro experiments demonstrated that GdDOTP5−-induced changes in relaxivity were silenced upon HA binding but could be recovered by acid elution of the complex, suggesting a novel strategy for creating highly sensitive, switchable MRI contrast agents.

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Journal ArticleDOI

In vivo MRI assessment of a novel GdIII-based contrast agent designed for high magnetic field applications.

Paulo Loureiro de Sousa, +11 more

- 01 Mar 2008 -

Contrast Media & Molecular Imaging

TL;DR: The dynamic gamma scintigraphic studies and the biodistribution experiments performed in Wistar rats with (153)Sm-enriched (*)Sm(3)L are indicative of a fast elimination via the kidneys, and the ratio of the relaxivities of the two compounds determined in vitro is retained under in vivo conditions.

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Journal ArticleDOI

Radiotheranostics with radiolanthanides: Design, development strategies, and medical applications

Kenji Mishiro, +3 more

- 15 Mar 2019 -

Coordination Chemistry Reviews

TL;DR: This review discusses radiotheranostics with radiolanthanides, focusing on the design, development strategies, and medical applications of radiolAnthanide-labeled probes.

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Journal ArticleDOI

Lanthanide chelates of (bis)-hydroxymethyl-substituted DTTA with potential application as contrast agents in magnetic resonance imaging.

Sara C. Silvério, +8 more

- 10 Jun 2009 -

Dalton Transactions

TL;DR: The bis-hydroxymethyl-substituted DTTA skeleton can be seen as a new lead for the synthesis of high relaxivity contrast agents, although its low thermodynamic and kinetic stability will limit its use to in vitro and animal studies.

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153Sm3+ and 111In3+ DTPA derivatives with high hepatic specificity: in vivo and in vitro studies

Figures

Citations

First in vivo MRI assessment of a self‐assembled metallostar compound endowed with a remarkable high field relaxivity

Silencing of Phosphonate-Gadolinium Magnetic Resonance Imaging Contrast by Hydroxyapatite Binding

In vivo MRI assessment of a novel GdIII-based contrast agent designed for high magnetic field applications.

Radiotheranostics with radiolanthanides: Design, development strategies, and medical applications

Lanthanide chelates of (bis)-hydroxymethyl-substituted DTTA with potential application as contrast agents in magnetic resonance imaging.

References

Table of Isotopes

Ligand design for selective complexation of metal ions in aqueous solution

The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging

MS-325: albumin-targeted contrast agent for MR angiography.

Mechanisms of bile formation, hepatic uptake, and biliary excretion.

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Q1. What contributions have the authors mentioned in the paper "Sm and in dtpa derivatives with high hepatic specificity: in vivo and in vitro studies" ?