18Fluorodeoxyglucose PET in schizophrenia
Summary (1 min read)
Methods
- Six male chronic schizophrenics, meeting Research Diagnostic Criteria (Spitzer et al ., 1978) , were recruited from the inpatient research unit of the PAVAMC .
- Three of the patients were also imaged while on neuroleptic medication : because of the small sample size, however, those data are not presented .
- An attempt was made to simulate the imaging conditions : the subjects reclined with eyes blindfolded as in the subsequent imaging session .
- The subjects were asked to press a button whenever the higherpitch tones occurred .
- On the day the images were taken, subjects were asked not to drink coffee and no medications were given .
Subject
- The Donner 280-crystal dynamic positron tomograph uses a fixed array of bismuth germanate crystals with a 50 cm patient port .
- Thirty to forty-five minutes before injection, several' transmission images, lasting 10 minutes each, were made at the selected levels .
- Two additional lines drawn at 45° through the midpoint divided each hemisphere into quadrants .
- The occipital region divided by the average events per pixel for all right-hemisphere cortical regions .
- This ranking was done without -knowledge-of the subjects' group membership .
Results
- The groups did not differ byage or tsFDGdose received nor did' their baseline vigilance performance differ .
- Again, there is evidence for a shift in 18FDG cortical pattern with increasing ventricular size, with relatively lower frontal ratios occurring in association with larger ventricles, also known as -6 .
- The authors present them because they raise the possibility that the findings of others may have been influenced by factors not systematically reported in those studies .
- They did not find age effects, but a smaller group (n = 21) was examined and no ratios of frontal values to posterior values were included .
- The high correlations between the manual and the automated quadrant measures set conservative limits for the reliability of both methods, and in most cases these are suprisingly high .
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Cites background from "18Fluorodeoxyglucose PET in schizop..."
...For analysis of the cerebral cortex, the use of semi-automated cortical circumferential profile methods produces i~ormation of the continuous spatial activity over the entire cortex, while improving reliability and decreasing bias (Buchsbaum et al., 1982, I984; Jernigan et al., 1985; Szechtman et al., 1988; Cleghorn et al., 1989; Gemmell et al., 1990; Maurer et al., 1990; Harris et al., 1991~; Pearlson et al., 1992)....
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...…i~ormation of the continuous spatial activity over the entire cortex, while improving reliability and decreasing bias (Buchsbaum et al., 1982, I984; Jernigan et al., 1985; Szechtman et al., 1988; Cleghorn et al., 1989; Gemmell et al., 1990; Maurer et al., 1990; Harris et al., 1991~; Pearlson et…...
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References
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