2.13 – Pyrimidines and their Benzo Derivatives
01 Jan 1984-Vol. 2, pp 57-155
About: The article was published on 1984-01-01. It has received 127 citations till now.
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1,104 citations
TL;DR: 1. Six-Membered Heterocycles with One Heteroatom 4155 7.6.1.
Abstract: 6.1. Oxadiazoles 4154 6.2. Diazaphospholes 4154 7. Six-Membered Heterocycles with One Heteroatom 4155 7.1. Pyridines 4155 7.2. Pyridinones 4155 7.3. Quinolines 4156 7.4. Quinolinones 4157 7.5. Isoquinolines 4157 7.6. Acridines 4158 7.7. Pyranones 4158 7.8. Flavones 4159 8. Six-Membered Heterocycles with Two Heteroatoms 4159 8.1. Pyridazinones 4159 8.2. Pyrimidines 4159 8.3. Pyrimidinones 4160 8.4. Quinazolines 4162 8.5. Quinazolinones 4162 8.6. Quinoxalines 4164 8.7. Quinoxalinediones 4165 8.8. Oxazines 4165 8.9. Oxazinones 4166 8.10. Thiazines 4166 9. Six-Membered Heterocycles with Three Heteroatoms 4166
549 citations
TL;DR: New series of sulfonamide derivatives of [1,3,4]thiadiazolo[3,2-a]pyrimidine were synthesized and investigated as antitumor agents and showed the highest affinity to DNA, while compounds 4h,i, 6a-c, 8 and 12-14 exhibited moderate activity.
135 citations
TL;DR: Six new 4-amino-5-cyano-2,6-diarylpyrimidines 5a-h has been synthesized in a facile manner by reacting the appropriate arylamidines 4a-d with bisnitriles 3a-e and three of them, viz., 7a-c have been found to be twice more active than aspirin.
83 citations
Journal Article•
TL;DR: Treatment of the hydrazino derivative with acetylacetone, benzaldehyde and acetic anhydride afforded pyrazolylpyrimidine, benzylidenehydrazonopyrimidine and triazolop Skyrimidine derivatives, respectively, some of these derivatives exhibited pronounced antimicrobial activity.
Abstract: Reaction of heteroaromatic o-aminonitrile with ethyl N--[bis(methylthio)methylene]amino acetate resulted in annelation of a thieno[3,2-e]imidazo[1,2-c]pyrimidine moiety in a one step process. [1,2,4]Triazolo[4,3-c]thieno- [3,2-e]pyrimidine derivatives were prepared by initial treatment of o-aminonitrile with carbon disulfide, followed by methylation with methyl iodide and subsequent reaction with benzhydrazide and thiosemicarbazide, respectively. Hydrazinothieno[2,3-d]pyrimidine was prepared by cyclization of heteroaromatic o-aminoester with formamide, followed by chlorination and subsequent displacement with hydrazine. Treatment of the hydrazino derivative with acetylacetone, benzaldehyde and acetic anhydride afforded pyrazolylpyrimidine, benzylidenehydrazonopyrimidine and triazolopyrimidine derivatives, respectively. Some of these derivatives exhibited pronounced antimicrobial activity.
72 citations
References
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Book•
01 Jan 1981
TL;DR: In this paper, the authors present a survey of general science, chemistry, physics, and physical sciences literature for general science students, including physics, biology, and chemistry, focusing on the following topics:
Abstract: This book should be of interest to students of general science, chemistry, physics and physical sciences.
594 citations
436 citations
TL;DR: Raman spectra of the commonly occurring purine and pyrimidine derivatives of ribonucleic acid are reported in this article, which serve as a basis for further investigation of intermolecular interactions of nucleic acid derivatives in aqueous solution.
375 citations
TL;DR: In this paper, the infra-red and Raman data for pyrazine, pyrimidine, and pyridazine were analyzed in terms of D 2 h symmetry.
236 citations