Journal ArticleDOI
2-aminothiophenes by the gewald reaction
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TLDR
In this paper, the authors present the most elegant and promising set of synthetic routes for the synthesis of 2-aminothiophenes by the Gewald reaction applications of this facile methodology to pharmaceuticals and dyestuffs have been demonstratedAbout:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 1999-03-01. It has received 265 citations till now. The article focuses on the topics: Gewald reaction.read more
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Classifications, properties, recent synthesis and applications of azo dyes.
TL;DR: This work has presented a very detailed review of the different classified azo dyes as a function of the number of azo groups and the appropriate functional groups and pointed out some chemical properties of these dyes such as reactivity, isomerization and tautomerism.
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Recent applications of multicomponent reactions in medicinal chemistry
TL;DR: An overview of recent literature concerning this topic is presented to provide insight into the applications of multicomponent reactions in this field.
Journal ArticleDOI
50th Anniversary Perspective: Polymer Functionalization
Eva Blasco,Michael B. Sims,Anja S. Goldmann,Anja S. Goldmann,Brent S. Sumerlin,Christopher Barner-Kowollik,Christopher Barner-Kowollik +6 more
TL;DR: The translation of small molecule chemistries into efficient methodologies for polymer functionalization spans several decades, enabling critical advances in soft matter materials synthesis with tailored and adaptive property profiles.
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Environmentally benign synthesis of heterocyclic compounds by combined microwave-assisted heterogeneous catalytic approaches†
TL;DR: In this article, the application of heterogeneous catalysis combined with microwave irradiation in the synthesis of heterocyclic compounds is reviewed and the authors highlight the environmentally benign and sustainable nature of the combined microwave-assisted heterogeneous catalytic methods, highlighting the green aspects of individual synthetic approaches.
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The Gewald multicomponent reaction.
Yijun Huang,Alexander Dömling +1 more
TL;DR: Synthetic scope and variations, usage, and structural biology of Gewald products are reviewed.
References
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Journal ArticleDOI
Heterocyclen aus CH-aciden Nitrilen, VIII. 2-Amino-thiophene aus methylenaktiven Nitrilen, Carbonylverbindungen und Schwefel
TL;DR: In this paper, the Einwirkung von Schwefel auf vinyloge methylenaktive Nitrile, gestattet auch die Einbeziehung von Alkylarylketonen in die Reaktion.
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Heterocyclen aus CH-aciden Nitrilen, VII. 2-Amino-thiophene aus α-Oxo-mercaptanen und methylenaktiven Nitrilen
TL;DR: In this paper, the α-Oxo-mercaptane reagieren mit Nitrilen, die in α-Stellung eine aktive Methylengruppe besitzen, basenkatalysiert zu 2.3.
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Synthesis of some novel azido/tetrazolothienopyrimidines and their reduction to 2,4‐diaminothieno[2,3‐d]pyrimidines
TL;DR: In this paper, a variety of 2,4-diaminothieno[2,3d]pyrimidines has been prepared through the reduction of the corresponding azido/tetrazolothienopyrimidine under acidic conditions.