2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
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..., 1993), 2-arachidonoylglycerol (Mechoulam et al., 1995; Sugiura et al., 1995), and noladin ether (Fig....
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...…to have been discovered in mammalian brain and certain other tissues (Devane et al., 1992b), the other compounds being homo- -linolenoylethanolamide and docosatetraenoylethanolamide (Hanus et al., 1993), 2-arachidonoylglycerol (Mechoulam et al., 1995; Sugiura et al., 1995), and noladin ether (Fig....
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1,857 citations
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...Three years later a second endocannabinoid, 2- arachidonoylglycerol (2-AG), was discovered independently by Mechoulam et al. (1995) and Sugiura et al. (1995)....
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...The two best characterized endocannabinoids, anandamide (arachidonoylethanolamide) (85) and 2-AG (242, 330), may be produced instead through cleavage of phospholipid precursors present in the membranes of neurons, glia, and other cells....
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...(330) arrived independently to the same conclusion....
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1,492 citations
Cites background from "2-Arachidonoylgylcerol: A Possible ..."
...…to be identified were N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (Devane et al., 1992; Mechoulam et al., 1995; Sugiura et al., 1995), each of which can activate both CB1 and CB2 receptors and is synthesized on demand in response to elevations of…...
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...The first endogenous cannabinoid receptor agonists (endocannabinoids) to be identified were N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (Devane et al., 1992; Mechoulam et al., 1995; Sugiura et al., 1995), each of which can activate both CB1 and CB2 receptors and is synthesized on demand in response to elevations of intracellular calcium (Howlett et al....
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