Figure 5: Proposed mechanism of MSTN gene control by Ang-(1-7), 20E and E2. According with this scheme, myostatin and protein synthesis would be controlled directly by ER and indirectly by Mas, while NO synthesis would be controlled directly by Ang-(1-7) (Tirupula et al., 2015) or 20E (Omanakuttan et al., 2016), and indirectly by E2 (Sobrino et al., 2017).
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