3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one: A Potent and Selective Serotonin (5-HT1B) Agonist and Rotationally Restricted Phenolic Analogue of 5-Methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.
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Cites methods from "3-(1,2,5,6-Tetrahydropyrid-4-yl)pyr..."
...…a WT or a 5-HT1B KO, in alternation) was brought to a novel room and placed for 6 min in the conditioning chamber, a mouse operant rectangular box (30 3 24 3 22 cm) with a floor made of 60 stainless steel rods (2 mm in diameter) spaced 5 mm and connected to a generator that delivered…...
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...5-HT1B and 5-HT1D binding sites were specifically labeled by adding 10 25 M 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT; RBI, Natick, MA], and 10 26 M 3-(1,2,5,6-tetrahydropyrid-4yl)pyrrolo[3,2-b]pyrid-5-one (CP 93129; Pfizer) (Macor et al., 1990), respectively, to the incubation medium....
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Cites background from "3-(1,2,5,6-Tetrahydropyrid-4-yl)pyr..."
...Third, the three putative 5-HT1B agonists presently tested display similar affinities for and potencies at 5-HT1B receptors, but they differ considerably in their activities at other 5-HT receptor subtypes (Macor et al., 1990; Koe et al., 1992a,b)....
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References
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