Journal ArticleDOI
3,3'-Diselenodipropionic acid (DSePA) induces reductive stress in A549 cells triggering p53-independent apoptosis: A novel mechanism for diselenides.
Vishwa V Gandhi,K.A. Gandhi,Liladhar B. Kumbhare,Jayant Sastri Goda,Vikram Gota,K.I. Priyadarsini,Amit Kunwar,Amit Kunwar +7 more
Reads0
Chats0
TLDR
In this article, the authors investigated the anticancer mechanisms of 3,3′-diselenodipropionic acid (DSePA), a redox-active organodiselenide in human lung cancer cells.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2021-11-01. It has received 11 citations till now. The article focuses on the topics: A549 cell & Unfolded protein response.read more
Citations
More filters
Journal ArticleDOI
Selenium metabolism and regulation of immune cells in immune‐associated diseases
TL;DR: The regulatory role of selenium metabolism in immune cells and immune‐associated diseases is introduced.
Journal ArticleDOI
Unravelling the molecular interaction of diselenodipropionic acid (DSePA) with human serum albumin (HSA)
TL;DR: Diselenodipropionic acid (DSePA), a selenocystine derivative, has emerged as a promising pharmacologically active organoselenium compound and there is a need to understand its transport mechanism to fully utilize its activity.
Journal ArticleDOI
Selenium and Platinum Compounds in Cancer Therapy: Potentiality of their Progeny as Future Chemotherapeutics
TL;DR: In this article , the authors have made a beginning to develop stable seleno-platinum compounds to explore their anti-cancer potentials, which can be used either as chemo-preventive or chemotherapeutic agents.
Journal ArticleDOI
Antitumor Activity and Reductive Stress by Platinum(II) N-Heterocyclic Carbenes based on Guanosine.
Maria Inês P. S. Leitão,Maria Turos-Cabal,Ana M. Sanchez-Sanchez,Clara S. B. Gomes,Federico Herrera,Vanesa Martín,Ana Petronilho +6 more
TL;DR: Platinum(II) complexes bearing N-heterocyclic carbenes based guanosine and caffeine have been synthesized by unassisted C-H oxidative addition, leading to the corresponding trans-hydride complexes as mentioned in this paper .
Journal ArticleDOI
3,3'-Diselenodipropionic acid immobilised gelatin gel: a biomimic catalytic nitric oxide generating material for topical wound healing application.
TL;DR: In this paper , a simple method has been developed for fabricating a diselenide grafted gelatin gel, which reduces NO donors such as S-nitroso-N-acetylpenicillamine (SNAP) by glutathione peroxidase-like mechanism to produce NO.
References
More filters
Journal ArticleDOI
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
Hyuna Sung,Jacques Ferlay,Rebecca L. Siegel,Mathieu Laversanne,Isabelle Soerjomataram,Ahmedin Jemal,Freddie Bray +6 more
TL;DR: The GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer (IARC) as mentioned in this paper show that female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung cancer, colorectal (11 4.4%), liver (8.3%), stomach (7.7%) and female breast (6.9%), and cervical cancer (5.6%) cancers.
Journal ArticleDOI
A simple technique for quantitation of low levels of DNA damage in individual cells
TL;DR: Human lymphocytes were exposed to X-irradiation or treated with H2O2 and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions and this technique appears to be sensitive and useful for detecting damage and repair in single cells.
Journal ArticleDOI
Activation of Apoptosis Signalling Pathways by Reactive Oxygen Species
TL;DR: ROS play a central role in cell signalling as well as in regulation of the main pathways of apoptosis mediated by mitochondria, death receptors and the endoplasmic reticulum, and current understanding of the role of ROS in each of these three main pathways is focused on.
Journal ArticleDOI
Regulation of glutathione synthesis
TL;DR: Dysregulation of GSH synthesis is increasingly being recognized as contributing to the pathogenesis of many pathological conditions, including diabetes mellitus, pulmonary fibrosis, cholestatic liver injury, endotoxemia and drug-resistant tumor cells.
Journal ArticleDOI
The Role of Mitochondria in Apoptosis
Chunxin Wang,Richard J. Youle +1 more
TL;DR: Comparing and contrast apoptosis pathways in Caenorhabditis elegans, Drosophila melanogaster, and mammals that indicate major mysteries remaining to be solved are compared.