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Journal ArticleDOI

3-Phenylsulfonyl-3-(2-propenyl)chroman-4-one

15 Jun 1997-Acta Crystallographica Section C-crystal Structure Communications (International Union of Crystallography (IUCr))-Vol. 53, Iss: 6, pp 793-794
TL;DR: In this article, the pyran ring adopts a sofa conformation and the bond angles around the two planar C atoms in the ring deviate from their ideal values.
Abstract: In the title compound, C 18 H 16 O 4 S, the pyran ring adopts a sofa conformation. The bond angles around the two planar C atoms in the ring deviate from their ideal values.
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TL;DR: In this article, a review of chromanone-4-one analogues is presented to convey comprehensive, critical and authoritative information about chromanones template in drug designing and development.
Abstract: Chromanone or Chroman-4-one is the most important and interesting heterobicyclic compound and acts as a building block in medicinal chemistry for isolation, designing and synthesis of novel lead compounds. Structurally, absence of a double bond in chromanone between C-2 and C-3 shows a minor difference from chromone but exhibits significant variations in biological activities. In the present review, various studies published on synthesis, pharmacological evaluation on chroman-4-one analogues are addressed to signify the importance of chromanone as a versatile scaffold exhibiting a wide range of pharmacological activities. But, due to poor yield in the case of chemical synthesis and expensive isolation procedure from natural compounds, more studies are required to provide the most effective and cost-effective methods to synthesize novel chromanone analogs to give leads to chemistry community. Considering the versatility of chromanone, this review is designed to impart comprehensive, critical and authoritative information about chromanone template in drug designing and development.

14 citations

Journal ArticleDOI
TL;DR: The crystal structures of CH3(C9H6O2)SO2C6H5 and CH3C8H8O2 )SO2−C6h5 have been determined by X-ray diffraction as discussed by the authors.
Abstract: The crystal structures of (i) CH3(C9H6O2)SO2C6H5 and (ii) CH3(C8H8O2)SO2−C6H5 have been determined by X-ray diffraction. (i) crystallizes in the monoclinic space groupP21/c with unit cell parametersa=8.814(1)A,b=10.310(1)A,c=15.841(4)A, β=98.17(1)o, andZ=4, and (ii) crystallizes in the orthorhombic space groupP212121 with unit cell parametersa=6.206(1)A,b=11.752(5)A,c=19.865(3)A, andZ=4. The pyran ring in both of them is in the distorted half-chair conformation with differeing degrees of distortion from the ideal.