4-{[5-(4-Chloro-phen-yl)-1-(4-fluoro-phen-yl)-1H-pyrazol-3-yl]carbon-yl}-N-ethyl-piperazine-1-carboxamide.
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TLDR
The asymmetric unit of the title compound, C23H23ClFN5O2, contains two crystallographically independent mol-ecules, and the pyrazole ring makes dihedral angles of 43.93 and 35.82°, respectively, with the fluoro and chloro-substituted benzene rings as discussed by the authors.Abstract:
The asymmetric unit of the title compound, C23H23ClFN5O2, contains two crystallographically independent molecules. In one molecule, the pyrazole ring makes dihedral angles of 43.93 (7) and 35.82 (7)°, respectively, with the fluoro- and chloro-substituted benzene rings, while the corresponding angles in the other molecule are 52.26 (8) and 36.85 (7)°. The piperazine rings adopt chair conformations. In the crystal, adjacent molecules are connected via intermolecular N—H⋯O, C—H⋯F, C—H⋯N and C—H⋯O hydrogen bonds, forming a two-dimensional network parallel to the bc plane. The crystal structure is further stabilized by a weak π–π interaction with a centroid–centroid distance of 3.6610 (8) A and by C—H⋯π interactions.read more
Citations
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Crystal structure studies of 4-ethylpiperazin-1-ium 3,5-dinitrobenzoate, 4-methylpiperazin-1-ium 3,5-dinitrobenzoate and 4-methylpiperazin-1-ium 4-iodobenzoate
Sriramapura D. Archana,Haruvegowda Kiran Kumar,Hemmige S. Yathirajan,Sabine Foro,Mohammed S. M. Abdelbaky,Santiago García-Granda +5 more
TL;DR: In this paper, the crystal structures of these compounds are built up of organic layers formed by the strong connection between the molcell by hydrogen bonds of type N-H⋯O.
References
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TL;DR: Interestingly all the synthesized compounds exhibited good antibacterial and antifungal activity (except 2a-c, 6a, 8, 9a).