Journal ArticleDOI
445. Studies in the sterol group. Part LIII. The preparation of 7-hydroxy-3-keto-Δ4-steroids
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This article is published in Journal of The Chemical Society (resumed).The article was published on 1952-01-01. It has received 13 citations till now. The article focuses on the topics: Sterol.read more
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Selective reactions and modification of functional groups in steroid chemistry
TL;DR: A review of selective reactions and modifications for the partial and total synthesis of steroids can be found in this paper, with a focus on tricyclic intermediates in total synthesis.
Journal ArticleDOI
Accumulation of 7α-hydroxy-4-cholesten-3-one and cholesta-4,6-dien-3-one in patients with cerebrotendinous xanthomatosis: Effect of treatment with chenodeoxycholic acid
Ingemar Björkhem,Ingemar Björkhem,Sverre Skrede,Sverre Skrede,Marie S. Buchmann,Marie S. Buchmann,Cara East,Cara East,Scott M. Grundy,Scott M. Grundy +9 more
TL;DR: Evidence was recently presented that an essential part of the accumulation of cholestanol in patients with cerebrotendinous xanthomatosis is due to acceleration of a novel pathway, involving 7α‐hydroxylated intermediates in bile acid biosynthesis as precursors.
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7-Hydroxylation of 3-oxygenated C27-, C28-, and C29-steroids in rat liver 18,000 g supernate.
TL;DR: Structurally closely related steroids have been tested as substrates for the NADPH-dependent cholesterol-and cholestanol-7 alpha-hydroxylase(s) considered to be the rate-limiting enzyme in bile acid biosynthesis and the importance of the beta-side of the steroid molecule is emphasized.
Journal ArticleDOI
Cholesterol conversion to δ4 -cholestenone by cholesterol oxidase in polyphasic systems : extension to the selective oxidation of 7β-hydroxycholesterol
TL;DR: The preparative use of cholesterol oxidase has been extended to polyphasic systems and the kinetic data for oxidation of 7α- and 7β-hydroxycholesterol in microemulsion with the enzyme from Streptomyces are similar to those of cholesterol.
Journal ArticleDOI
Structure recognition of hydroxy-Δ4-3-ketosteroids using systematic spectral studies
TL;DR: Ultraviolet absorption spectra in ethanol, in 0.066N alkaline ethanol, and in concentrated sulfuric acid and molecular rotational differences are summarized and it is possible to differentiate among the several hydroxy-Δ4-3-ketosteroids, and early recognition of structure is facilitated in biological studies.