Journal ArticleDOI
5-HT and mechanisms of defence.
Reads0
Chats0
TLDR
Three forms of aversion are considered and it is suggested they bring different anatomical structures and 5-HT systems into play and results in different groups of psychological symptoms.Abstract:
are concerned with adaptive responses to aversive events. Aversive stimuli can be defined as stimuli which motivate avoidance behaviour. This definition encompasses negative incentives and reinforcers and much of what passes under vaguer terms such as ’punishers’ and ’stresses’. Aversive stimuli can be considered in three groups and we suggest they bring different anatomical structures and 5-HT systems into play. Dysfunction in these central mechanisms of aversion results in different groups of psychological symptoms. The three forms of aversion are summarized below and they form the basis of this article.read more
Citations
More filters
Journal ArticleDOI
Inhibition and impulsivity: Behavioral and neural basis of response control
Andrea Bari,Trevor W. Robbins +1 more
TL;DR: This review will review the current models of behavioral inhibition along with their expression via underlying brain regions, including those involved in the activation of the brain's emergency 'brake' operation, those engaged in more controlled and sustained inhibitory processes and other ancillary executive functions.
Journal ArticleDOI
A two-dimensional neuropsychology of defense: fear/anxiety and defensive distance
Neil McNaughton,Philip J. Corr +1 more
TL;DR: A picture of the neural systems controlling defense that updates and simplifies Gray's "Neuropsychology of Anxiety" is presented, based on two behavioural dimensions: 'def defensive distance' as defined by the Blanchards and 'defensive direction'.
Journal ArticleDOI
The neurobiology and control of anxious states
TL;DR: The present article focuses in particular upon the multifarious and complex roles of individual modulators, often as a function of the specific receptor type and neuronal substrate involved in their actions; novel targets for the management of anxiety disorders; the influence of neurotransmitters and other agents upon performance in the VCT; data acquired from complementary pharmacological and genetic strategies and, finally, several open questions likely to orientate future experimental- and clinical-research.
Journal ArticleDOI
Role of 5-HT in stress, anxiety, and depression
TL;DR: It is found that 24 h after electrolytic lesion of the rat MRN glandular gastric ulcers occurred, and the immune response to the mitogen concanavalin A was depressed, these results are compatible with the hypothesis that the MRN-dorsal hippocampus 5-HT system attenuates stress by facilitation of hippocampal 5- HT1A-mediated neurotransmission.
Journal ArticleDOI
Neuroanatomical Hypothesis of Panic Disorder, Revised
TL;DR: Medications, particularly those that influence the serotonin system, are hypothesized to desensitize the fear network from the level of the amygdala through its projects to the hypothalamus and the brainstem, and effective psychosocial treatments may also reduce contextual fear and cognitive misattributions.
References
More filters
Journal ArticleDOI
Précis of The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-Hippocampal System..
TL;DR: It is proposed that these drugs reduce anxiety by impairing the functioning of a widespread neural system including the septo-hippocampal system (SHS), the Papez circuit, the prefrontal cortex, and ascending monoaminergic and cholinergic pathways which innervate these forebrain structures.
Journal ArticleDOI
An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat
Efrain C. Azmitia,Menahem Segal +1 more
TL;DR: The differential projections from the dorsal raphe and median raphe nuclei of the midbrain were autoradiographically traced in the rat brain after 3H‐proline micro‐injections to identify six ascending fiber tracts.
Journal ArticleDOI
Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear
TL;DR: Electrolytic and ibotenic acid lesions of the LH demonstrate that neurons in the LH are involved in the autonomic, but not the behavioral, conditioned response pathway, whereas neurons inThe caudal CG are involvedIn the behavioral and autonomic pathway, although different efferent projections of the central amygdala thus appear to mediate the behavioraland autonomic concomitants of conditioned fear.
Journal ArticleDOI
The lateral amygdaloid nucleus: Sensory interface of the amygdala in fear conditioning
TL;DR: AL is an essential link in the circuitry through which auditory stimuli are endowed with affective properties and may function as the sensory interface of the amygdala during emotional learning.
Journal ArticleDOI
Serotonergic Studies in Patients with Affective and Personality Disorders: Correlates with Suicidal and Impulsive Aggressive Behavior
Coccaro Ef,Larry J. Siever,Howard Klar,Gail Maurer,Karen Cochrane,Thomas B. Cooper,Richard C. Mohs,Kenneth L. Davis +7 more
TL;DR: It is suggested that reduced central serotonergic function is present in a subgroup of patients with major affective and/or personality disorder and is associated with history of suicide attempt in patients with either disorder, but with impulsive aggression in Patients with personality disorder only.