6-chloro-8-acetonitrile oxy imidazo [1,2-a] pyridine-3-carbonitrile preparation method

TLDR: In this article, a 6-chloro-8-acetonitrile oxy imidazo [1,2-a] pyridine-3-carbonitrile preparation method is described.

Abstract: The present invention relates to a 6-chloro-8-acetonitrile oxy imidazo [1,2-a] pyridine-3-carbonitrile preparation method. The preparation method comprises the following steps: N, N-dimethylformamide dimethyl acetal is reacted with 2-amino-3-hydroxy-5-chloro pyridine in a certain proportion at 40-100 DEG C to obtain N, N-dimethyl-N '-2-(5-chloro-3-hydroxy-pyridine) yl-formamidine intermediate, under the effect of an alkali, in a certain solvent, the N, N-dimethyl-N '-2-(5-chloro- 3-hydroxy-pyridine) yl-formamidine intermediate is reacted with bromoacetonitrile in certain proportion at 50-160 DEG C for 3-15 hours, after the reaction, a 6-chloro-8-acetonitrile oxy imidazo [1,2-a] pyridine-3-carbonitrile crude product is obtained by cooling to room temperature, extracting with ethyl acetate, washing with water and saturated salt water, drying with anhydrous sodium sulfate, rotation evaporation and concentration, and a pure product is obtained by recrystallization of the crude product. Reaction materials are relatively easy to obtain, and are reasonable in prices, reaction conditions are mild, easy to operate, and easy to control, post-processing is simple, product quality is stable, and purity is high.