Fig. 2. Structure of the anti-angiogenic drug linomide (8) in two different conformations. The 'cis' conformation of linomide (8') can be superimposed to the low energy 'cis' conformation of the coumarinic aryl esters (9') but not to the stable conformation of the coumarinic aryl amides (10) characterised by the existence of a strong intra-molecular hydrogen bond.
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