scispace - formally typeset
Open AccessJournal ArticleDOI

6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis

I. Kempen, +9 more
- 01 Dec 2008 - 
- Vol. 43, Iss: 12, pp 2735-2750
Reads0
Chats0
TLDR
Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated.
About: 
This article is published in European Journal of Medicinal Chemistry.The article was published on 2008-12-01 and is currently open access. It has received 48 citations till now. The article focuses on the topics: Aryl & Thioester.

read more

Figures
Citations
More filters
Journal ArticleDOI

An ecofriendly approach to the synthesis of 2-imino- and 2-oxo-3-phenylsulfonyl-2H-chromenes

Tatiana A. Dias, +1 more
- 26 Sep 2012 - 
TL;DR: In this article, an efficient synthesis for 2-imino-3-phenylsulfonyl-2 H -chromenes was developed from the Knoevenagel condensation of (phenyl sulfonyl)acetonitrile and salicylaldehydes in aqueous sodium carbonate solution.
Journal ArticleDOI

DFT, IR, Raman and NMR study of the coordination ability of coumarin-3-carboxylic acid to Pr(III)

Ivelina Georgieva, +4 more
- 27 Aug 2010 - 
TL;DR: A new complex of coumarin-3-carboxylic acid (HCCA) with Pr(III) is synthesized and its structure and molecular properties are investigated by elemental analysis, IR, Raman, NMR measurements and quantum chemical calculations as mentioned in this paper.
Journal ArticleDOI

Synthesis and α-glucosidase inhibitory, DPPH scavenging activity of substituted 2-oxo-2H-chromen-7-yl-dihydrogen phosphate derivatives

J. Ashok Kumar, +4 more
- 01 Nov 2011 - 
TL;DR: A series of phosphorylated coumarin derivatives (4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j) were synthesized by Pechmann condensation, phosphorylation, and debenzylation reactions in very good yields as discussed by the authors.
Journal ArticleDOI

Molecular first order hyperpolarizability and vibrational spectral investigation of Warfarin sodium

Irena Kostova, +2 more
- 09 Dec 2010 - 
TL;DR: In this paper, the experimental and theoretical vibrational spectra of Warfarin sodium (WS) were studied and the optimized geometry and vibrational wavenumbers have been computed using HF/6-31G(d) and for the DFT, B3LYP/6 -31G (d), 6-31g(d,p), and cc-pVDZ and B3PW91/6 −31G
Journal ArticleDOI

Effective Synthesis of tert-Butyl-Substituted 3-Carboxy Coumarins in Water Using TEBAC as Catalyst

Yang Li, +1 more
- 26 Mar 2012 - 
TL;DR: In this paper, a facile synthesis of novel tert-butyl substituted 3-carboxycoumarin derivatives is described, featuring the one-pot reaction of tert butyl substituted salicylaldehydes with Meldrum's acid in water using triethylbenzyl ammonium chloride as catalyst.
References
More filters
Journal ArticleDOI

Studies on Coumarins and Coumarin-Related Compounds to Determine their Therapeutic Role in the Treatment of Cancer

Aoife Lacy, +1 more
- 31 Oct 2004 - 
TL;DR: These studies suggest that both genistein and esculetin exerted the most potent inhibitory effect on cell growth in comparison to the other two compounds, which may lead to its use in cancer therapy.
Journal ArticleDOI

Synthetic and natural coumarins as cytotoxic agents.

Irena Kostova
- 01 Jan 2005 - 
TL;DR: There is still a long way to go until the authors know which cytotoxic agent will clinically be suitable for what tumor entity for treatment, because promising data have been reported for a series of these agents, and the results from different coumarins with various tumor lines are contradictory in part.
Journal ArticleDOI

Sunitinib malate for the treatment of solid tumours: a review of current clinical data

Robert J. Motzer, +3 more
- 24 Apr 2006 - 
TL;DR: The present review provides an updated summary of emerging clinical experience with Sunitinib malate, an oral multitargeted tyrosine kinase inhibitor with antitumour and antiangiogenic activity that recently received approval from the FDA.
Journal Article

Antiangiogenic Effects of the Quinoline-3-Carboxamide Linomide

Jasminka Vukanovic, +5 more
- 15 Apr 1993 - 
TL;DR: It was demonstrated that due to its antiangiogenic activity, linomide treatment of rats bearing prostate cancers resulted in a more than 40% decrease in tumor blood flow and blood flow to a variety of non-tumor bearing organs was not decreased suggesting that linomides selectively inhibits angiogenesis and does not induce loss of established blood vessels.
Journal ArticleDOI

Current status of angiogenesis inhibitors combined with radiation therapy

Carsten Nieder, +3 more
- 01 Aug 2006 - 
TL;DR: Early results suggest that acute toxicity is acceptable, planned surgery after such treatment is feasible, and that further evaluation of such combined modality treatment is warranted.
Related Papers (5)

3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo.

I. Kempen, +9 more
- 07 Apr 2003 - 

Ketocoumarins: A new class of triplet sensitizers

Dnolad P. Specht, +2 more
- 01 Jan 1982 - 

Uncatalysed reactions in water: Part 2. Preparation of 3-carboxycoumarins

Raimondo Maggi, +4 more
- 01 Jan 2001 - 

Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides.

Franco Chimenti, +10 more
- 15 Aug 2010 - 

Pharmacological and biochemical actions of simple coumarins : Natural products with therapeutic potential

J. R. S. Hoult, +1 more
- 01 Jun 1996 - 
Frequently Asked Questions (1)
Q1. What are the contributions in "6-substituted 2-oxo-2h-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis" ?

This work confirms the interest of aryl esters of 6-substituted coumarin-3-carboxylic acids as potential new anticancer agents.