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6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis

I. Kempen, +9 more
- 01 Dec 2008 - 
- Vol. 43, Iss: 12, pp 2735-2750
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TLDR
Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated.
About: 
This article is published in European Journal of Medicinal Chemistry.The article was published on 2008-12-01 and is currently open access. It has received 48 citations till now. The article focuses on the topics: Aryl & Thioester.

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Recent Advances on Synthesis of Fused Chromeno‐Quinoline Heterocycles under Transition Metal‐Free Condition

Sourav Mal, +1 more
- 11 Feb 2022 - 
TL;DR: In this paper , a review summarizes recent development in transition metal-free approach toward synthesis of chromeno-quinoline derivatives, including single-step and multi-step synthetic protocols.
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New Biological Investigations on 3-Bromophenyl 6-Acetoxymethyl-2-oxo-2H-1-Benzopyran-3-Carboxylate as Anti-angiogenic Agent

Marc Hemmer, +10 more
- 01 May 2010 - 
TL;DR: This study identifies IK9 as a new potent inhibitor of angiogenesis and suggests its potential use as a therapeutic agent through a complex mechanism of action via direct or indirect effects on endothelial cell properties.
Journal ArticleDOI

One-pot Synthesis of Novel bisChroman-3, 4-dicarboxamides Containing Lipophilic Spacers

Enayatollah Sheikhhosseini
- 17 Jan 2020 - 
TL;DR: An approach to the synthesis of some new bisdiamidated coumarin carboxamides were synthesized with effective anticoagulant activity, and with inhibition against BACE1, hMAO, acetylcholinesterase, and tumorogenesis.
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Application of coumarin derivative in pharmacy as inhibitor of KLK7

Tan Xiao, +1 more
TL;DR: In this paper, an application of acoumarin derivative as an inhibitor of KLK7 and in preparation of a drug for treating pancreatic cancer was described. But the structural formula of the acou marin derivative is not mentioned in the description.
Journal ArticleDOI

Ru(II) catalyzed chelation assisted C(sp2)-H bond functionalization along with concomitant (4 + 2) annulation.

Anindita Sarkar, +2 more
- 26 Jun 2023 - 
TL;DR: In this paper, the vinylic C(sp2)-H bond of coumarin-3-carboxamide under the influence of inexpensive Ru(II)-metal has been exploited as the chelating fragment to manifest C (sp2-H bond functionalization with a concomitant (4 + 2) annulation reaction, resulting in heterocyclic ring-forming protocols along with sulfoxonium ylide and iodonium Ylide as representative bench-stable carbene surrogates.
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Journal ArticleDOI

Studies on Coumarins and Coumarin-Related Compounds to Determine their Therapeutic Role in the Treatment of Cancer

Aoife Lacy, +1 more
- 31 Oct 2004 - 
TL;DR: These studies suggest that both genistein and esculetin exerted the most potent inhibitory effect on cell growth in comparison to the other two compounds, which may lead to its use in cancer therapy.
Journal ArticleDOI

Synthetic and natural coumarins as cytotoxic agents.

Irena Kostova
- 01 Jan 2005 - 
TL;DR: There is still a long way to go until the authors know which cytotoxic agent will clinically be suitable for what tumor entity for treatment, because promising data have been reported for a series of these agents, and the results from different coumarins with various tumor lines are contradictory in part.
Journal ArticleDOI

Sunitinib malate for the treatment of solid tumours: a review of current clinical data

Robert J. Motzer, +3 more
- 24 Apr 2006 - 
TL;DR: The present review provides an updated summary of emerging clinical experience with Sunitinib malate, an oral multitargeted tyrosine kinase inhibitor with antitumour and antiangiogenic activity that recently received approval from the FDA.
Journal Article

Antiangiogenic Effects of the Quinoline-3-Carboxamide Linomide

Jasminka Vukanovic, +5 more
- 15 Apr 1993 - 
TL;DR: It was demonstrated that due to its antiangiogenic activity, linomide treatment of rats bearing prostate cancers resulted in a more than 40% decrease in tumor blood flow and blood flow to a variety of non-tumor bearing organs was not decreased suggesting that linomides selectively inhibits angiogenesis and does not induce loss of established blood vessels.
Journal ArticleDOI

Current status of angiogenesis inhibitors combined with radiation therapy

Carsten Nieder, +3 more
- 01 Aug 2006 - 
TL;DR: Early results suggest that acute toxicity is acceptable, planned surgery after such treatment is feasible, and that further evaluation of such combined modality treatment is warranted.
Related Papers (5)

3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo.

I. Kempen, +9 more
- 07 Apr 2003 - 

Ketocoumarins: A new class of triplet sensitizers

Dnolad P. Specht, +2 more
- 01 Jan 1982 - 

Uncatalysed reactions in water: Part 2. Preparation of 3-carboxycoumarins

Raimondo Maggi, +4 more
- 01 Jan 2001 - 

Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides.

Franco Chimenti, +10 more
- 15 Aug 2010 - 

Pharmacological and biochemical actions of simple coumarins : Natural products with therapeutic potential

J. R. S. Hoult, +1 more
- 01 Jun 1996 - 
Frequently Asked Questions (1)
Q1. What are the contributions in "6-substituted 2-oxo-2h-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis" ?

This work confirms the interest of aryl esters of 6-substituted coumarin-3-carboxylic acids as potential new anticancer agents.