A 1H and 13c Nmr study of the structure and tautomerism of 4-pyrazolylpyrazolinones
TL;DR: In this paper, it was shown that the primary reaction products between dehydroacetic acid and p-chlorophenylhydrazine or 4-phenylthiazol-2-yl hydrazine are 4-acetylacetyl-5-hydroxypyrazoles.
About: This article is published in Journal of Heterocyclic Chemistry.The article was published on 1990-05-01. It has received 31 citations till now. The article focuses on the topics: Dehydroacetic acid & Tautomer.
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TL;DR: In this paper, the carbon-13 chemical shifts and coupling constants of 1168 pyrazoles are reported, some of them in several solvents, and discussed on the basis of statistical treatment and qualitative comparisons.
Abstract: The carbon-13 chemical shifts and coupling constants of 1168 pyrazoles are reported, some of them in several solvents. These data are briefly discussed on the basis of statistical treatment and qualitative comparisons.
110 citations
TL;DR: In this paper, α,β-unsaturated carbonyl compounds, obtained by the reaction of DHA and aromatic (or heteroaromatic) aldehydes, with o -aminothiophenol results in the formation of 1,5-benzothiazepines and/or 1,4-benzinothiazines depending upon the reaction conditions and structure of the aldehyde.
77 citations
Patent•
15 Apr 2006TL;DR: In this paper, the authors present an application related to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases, and their use in the preparation of medicaments for treatment or prevention of diseases.
Abstract: The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
44 citations
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86 citations
TL;DR: In this paper, 13C shielding data for 100 derivatives of pyrazole are reported, including methyl, ethyl, n-propyl, tert-butyl, phenyl, hydroxymethyl, carboxyl, ethoxycarbonyl, cyano, amino, hydrazino, nitro, azido, chloro, bromo and iodo groups.
Abstract: 13C shielding data for 100 derivatives of pyrazole are reported. These include methyl, ethyl, n-propyl, tert-butyl, phenyl, hydroxymethyl, carboxyl, ethoxycarbonyl, cyano, amino, hydrazino, nitro, azido, chloro, bromo and iodo groups as substituents on the ring carbon atoms.
42 citations
TL;DR: The colourless crystalline form of the benzoylpyrazolone (2) has molecules with the NH structure (2c) stabilized by intermolecular hydrogen bonds as mentioned in this paper.
Abstract: The colourless crystalline form of the benzoylpyrazolone (2) has molecules with the NH structure (2c) stabilized by intermolecular hydrogen bonds. At room temperature crystals are monoclinic: P21/c, a 13.508(5), b 9.124(4), c 11.451(3)Ǻ, β 90.80(3)°, Z4; the structure was refined to R 0.059, Rw 0.048. The acetoacetylpyrazolone (3) has the OH structure (3c) with two intramolecular hydrogen bonds. At 193 K crystals are triclinic: Pī , a 7.142(2), b 13.704(8), c 14.699(7)Ǻ, α 117.36(3), β 96.87(3), γ 93.73(3)°, Z 4; the structure was refined to R 0.049, Rw 0.054.
40 citations
TL;DR: In this paper, the carbon-13nmr spectra of 18 thiazoles with different substituents (R = CH3, C6H5, Cl, Br, NH2 et N3) have been recorded.
Abstract: Carbon-13 nmr spectra of 18 thiazoles with different substituents (R = CH3, C6H5, Cl, Br, NH2 et N3) have been recorded. The 13C chemical shifts and the nJ(C,H) coupling constants are discussed as ...
39 citations